FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966420005> ?p ?o ?g. }

• W1966420005 endingPage "230" @default.
• W1966420005 startingPage "224" @default.
• W1966420005 abstract "We hypothesized that the endothelial-derived relaxing factor nitric oxide may contribute to low resting vascular tone and may attenuate vasoconstrictor action in the human fetal-placental circulation.Isolated human placental cotyledons were dually perfused in vitro, and the effects of N-monomethyl-L-arginine and N-nitro-L-arginine (3 x 10(-4) mol/L), which are nonmetabolizable analogs of L-arginine, the substrate for nitric oxide synthase, on resting perfusion pressure and on the fetal-placental circulation preconstricted with U46619 (10(-8) mol/L) or endothelin-1 (10(-8) mol/L) were established. Responses before and after inhibition were compared by paired t test. The effects of glyceryl trinitrate (10(-6) mol/L), acetylcholine (10(-4) mol/L), the calcium ionophore A23187 (10(-6) mol/L), and histamine (10(-8) to 10(-4) mol/L) were also determined in the preconstricted fetal-placental circulation.Both N-monomethyl-L-arginine and N-nitro-L-arginine (3 x 10(-4) mol/L) increased resting perfusion pressure (p less than 0.06), and N-nitro-L-arginine promptly and significantly increased perfusion pressure in the fetal-placental circulation preconstricted with U46619 (p less than 0.0004) or endothelin-1 (p less than 0.06). Nitric oxide generated by addition of glyceryl trinitrate (10(-6) mol/L) attenuated the vasoconstrictor effects of U46619 (p less than 0.026) or endothelin-1 (p less than 0.01). Neither acetylcholine nor the calcium ionophore A23187 had an effect on the fetal-placental circulation, whereas bradykinin further increased perfusion pressure. Histamine only relaxed the preconstricted preparations at concentrations (10(-6) to 10(-4) mol/L) above those shown to release nitric oxide in other systems.The stimulus to nitric oxide generation in the fetal-placental circulation may be hydrodynamic. Nitric oxide appears to contribute to maintenance of basal vascular tone and to attenuate the actions of vasoconstrictors in this circulation." @default.
• W1966420005 created "2016-06-24" @default.
• W1966420005 creator A5001243644 @default.
• W1966420005 creator A5040500290 @default.
• W1966420005 creator A5048209900 @default.
• W1966420005 creator A5073265310 @default.
• W1966420005 date "1992-01-01" @default.
• W1966420005 modified "2023-09-25" @default.
• W1966420005 title "Attenuation of the vasoconstrictor effects of thromboxane and endothelin by nitric oxide in the human fetal-placental circulation" @default.
• W1966420005 cites W1965751588 @default.
• W1966420005 cites W1966322594 @default.
• W1966420005 cites W1970640107 @default.
• W1966420005 cites W1973452215 @default.
• W1966420005 cites W1989229224 @default.
• W1966420005 cites W1993935151 @default.
• W1966420005 cites W2015637991 @default.
• W1966420005 cites W2022705084 @default.
• W1966420005 cites W2048635427 @default.
• W1966420005 cites W2059379142 @default.
• W1966420005 cites W2089259890 @default.
• W1966420005 cites W2122001364 @default.
• W1966420005 cites W2126624423 @default.
• W1966420005 cites W2145671860 @default.
• W1966420005 cites W4241558103 @default.
• W1966420005 doi "https://doi.org/10.1016/0002-9378(92)91863-6" @default.
• W1966420005 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1733199" @default.
• W1966420005 hasPublicationYear "1992" @default.
• W1966420005 type Work @default.
• W1966420005 sameAs 1966420005 @default.
• W1966420005 citedByCount "191" @default.
• W1966420005 countsByYear W19664200052012 @default.
• W1966420005 countsByYear W19664200052013 @default.
• W1966420005 countsByYear W19664200052014 @default.
• W1966420005 countsByYear W19664200052015 @default.
• W1966420005 countsByYear W19664200052016 @default.
• W1966420005 countsByYear W19664200052017 @default.
• W1966420005 countsByYear W19664200052018 @default.
• W1966420005 countsByYear W19664200052020 @default.
• W1966420005 countsByYear W19664200052021 @default.
• W1966420005 crossrefType "journal-article" @default.
• W1966420005 hasAuthorship W1966420005A5001243644 @default.
• W1966420005 hasAuthorship W1966420005A5040500290 @default.
• W1966420005 hasAuthorship W1966420005A5048209900 @default.
• W1966420005 hasAuthorship W1966420005A5073265310 @default.
• W1966420005 hasConcept C120770815 @default.
• W1966420005 hasConcept C126322002 @default.
• W1966420005 hasConcept C134018914 @default.
• W1966420005 hasConcept C144980905 @default.
• W1966420005 hasConcept C146957229 @default.
• W1966420005 hasConcept C149601957 @default.
• W1966420005 hasConcept C170493617 @default.
• W1966420005 hasConcept C172680121 @default.
• W1966420005 hasConcept C185592680 @default.
• W1966420005 hasConcept C2775910092 @default.
• W1966420005 hasConcept C2776785769 @default.
• W1966420005 hasConcept C2777468819 @default.
• W1966420005 hasConcept C2777622882 @default.
• W1966420005 hasConcept C2779234561 @default.
• W1966420005 hasConcept C2779591629 @default.
• W1966420005 hasConcept C2781024287 @default.
• W1966420005 hasConcept C2909649922 @default.
• W1966420005 hasConcept C515207424 @default.
• W1966420005 hasConcept C519581460 @default.
• W1966420005 hasConcept C54355233 @default.
• W1966420005 hasConcept C55493867 @default.
• W1966420005 hasConcept C71924100 @default.
• W1966420005 hasConcept C86803240 @default.
• W1966420005 hasConcept C89560881 @default.
• W1966420005 hasConceptScore W1966420005C120770815 @default.
• W1966420005 hasConceptScore W1966420005C126322002 @default.
• W1966420005 hasConceptScore W1966420005C134018914 @default.
• W1966420005 hasConceptScore W1966420005C144980905 @default.
• W1966420005 hasConceptScore W1966420005C146957229 @default.
• W1966420005 hasConceptScore W1966420005C149601957 @default.
• W1966420005 hasConceptScore W1966420005C170493617 @default.
• W1966420005 hasConceptScore W1966420005C172680121 @default.
• W1966420005 hasConceptScore W1966420005C185592680 @default.
• W1966420005 hasConceptScore W1966420005C2775910092 @default.
• W1966420005 hasConceptScore W1966420005C2776785769 @default.
• W1966420005 hasConceptScore W1966420005C2777468819 @default.
• W1966420005 hasConceptScore W1966420005C2777622882 @default.
• W1966420005 hasConceptScore W1966420005C2779234561 @default.
• W1966420005 hasConceptScore W1966420005C2779591629 @default.
• W1966420005 hasConceptScore W1966420005C2781024287 @default.
• W1966420005 hasConceptScore W1966420005C2909649922 @default.
• W1966420005 hasConceptScore W1966420005C515207424 @default.
• W1966420005 hasConceptScore W1966420005C519581460 @default.
• W1966420005 hasConceptScore W1966420005C54355233 @default.
• W1966420005 hasConceptScore W1966420005C55493867 @default.
• W1966420005 hasConceptScore W1966420005C71924100 @default.
• W1966420005 hasConceptScore W1966420005C86803240 @default.
• W1966420005 hasConceptScore W1966420005C89560881 @default.
• W1966420005 hasIssue "1" @default.
• W1966420005 hasLocation W19664200051 @default.
• W1966420005 hasLocation W19664200052 @default.
• W1966420005 hasOpenAccess W1966420005 @default.
• W1966420005 hasPrimaryLocation W19664200051 @default.
• W1966420005 hasRelatedWork W108881990 @default.

• next