FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966420007> ?p ?o ?g. }

• W1966420007 endingPage "232.e2" @default.
• W1966420007 startingPage "222" @default.
• W1966420007 abstract "Emerging data suggest that changes in intestinal permeability and increased gut microbial translocation contribute to the inflammatory pathway involved in nonalcoholic steatohepatitis (NASH) development. Numerous studies have investigated the association between increased intestinal permeability and NASH. Our meta-analysis of this association investigates the underlying mechanism.A meta-analysis was performed to compare the rates of increased intestinal permeability in patients with NASH and healthy controls. To further address the underlying mechanism of action, we studied changes in intestinal permeability in a diet-induced (methionine-and-choline-deficient; MCD) murine model of NASH. In vitro studies were also performed to investigate the effect of MCD culture medium at the cellular level on hepatocytes, Kupffer cells, and intestinal epithelial cells.Nonalcoholic fatty liver disease (NAFLD) patients, and in particular those with NASH, are more likely to have increased intestinal permeability compared with healthy controls. We correlate this clinical observation with in vivo data showing mice fed an MCD diet develop intestinal permeability changes after an initial phase of liver injury and tumor necrosis factor-α (TNFα) induction. In vitro studies reveal that MCD medium induces hepatic injury and TNFα production yet has no direct effect on intestinal epithelial cells. Although these data suggest a role for hepatic TNFα in altering intestinal permeability, we found that mice genetically resistant to TNFα-myosin light chain kinase (MLCK)-induced intestinal permeability changes fed an MCD diet still develop increased permeability and liver injury.Our clinical and experimental results strengthen the association between intestinal permeability increases and NASH and also suggest that an early phase of hepatic injury and inflammation contributes to altered intestinal permeability in a fashion independent of TNFα and MLCK." @default.
• W1966420007 created "2016-06-24" @default.
• W1966420007 creator A5019885957 @default.
• W1966420007 creator A5022825489 @default.
• W1966420007 creator A5024961838 @default.
• W1966420007 creator A5026555041 @default.
• W1966420007 creator A5028258194 @default.
• W1966420007 creator A5030616812 @default.
• W1966420007 creator A5031415147 @default.
• W1966420007 creator A5035211037 @default.
• W1966420007 creator A5038972103 @default.
• W1966420007 creator A5055658784 @default.
• W1966420007 creator A5057250036 @default.
• W1966420007 creator A5070349336 @default.
• W1966420007 creator A5071518966 @default.
• W1966420007 creator A5080210254 @default.
• W1966420007 creator A5086659113 @default.
• W1966420007 creator A5086829779 @default.
• W1966420007 date "2015-03-01" @default.
• W1966420007 modified "2023-10-12" @default.
• W1966420007 title "Hepatic Injury in Nonalcoholic Steatohepatitis Contributes to Altered Intestinal Permeability" @default.
• W1966420007 cites W1493187770 @default.
• W1966420007 cites W1940172037 @default.
• W1966420007 cites W1966776937 @default.
• W1966420007 cites W1968305010 @default.
• W1966420007 cites W1969579498 @default.
• W1966420007 cites W1970440320 @default.
• W1966420007 cites W1974863952 @default.
• W1966420007 cites W1980269166 @default.
• W1966420007 cites W1984371486 @default.
• W1966420007 cites W1997273123 @default.
• W1966420007 cites W2013877744 @default.
• W1966420007 cites W2025709002 @default.
• W1966420007 cites W2026176653 @default.
• W1966420007 cites W2027391841 @default.
• W1966420007 cites W2028842505 @default.
• W1966420007 cites W2030407395 @default.
• W1966420007 cites W2035378093 @default.
• W1966420007 cites W2039632779 @default.
• W1966420007 cites W204046373 @default.
• W1966420007 cites W2054776754 @default.
• W1966420007 cites W2055222262 @default.
• W1966420007 cites W2056882652 @default.
• W1966420007 cites W2062140428 @default.
• W1966420007 cites W2067740038 @default.
• W1966420007 cites W2080766557 @default.
• W1966420007 cites W2087265885 @default.
• W1966420007 cites W2089713062 @default.
• W1966420007 cites W2098392939 @default.
• W1966420007 cites W2102388558 @default.
• W1966420007 cites W2106549878 @default.
• W1966420007 cites W2107328434 @default.
• W1966420007 cites W2114315236 @default.
• W1966420007 cites W2125435699 @default.
• W1966420007 cites W2132194624 @default.
• W1966420007 cites W2132692852 @default.
• W1966420007 cites W2132739516 @default.
• W1966420007 cites W2139389920 @default.
• W1966420007 cites W2141158324 @default.
• W1966420007 cites W2142613038 @default.
• W1966420007 cites W2144275312 @default.
• W1966420007 cites W2147954623 @default.
• W1966420007 cites W2151623669 @default.
• W1966420007 cites W2159469729 @default.
• W1966420007 cites W2243416090 @default.
• W1966420007 cites W2328023807 @default.
• W1966420007 cites W2464002019 @default.
• W1966420007 cites W8877553 @default.
• W1966420007 doi "https://doi.org/10.1016/j.jcmgh.2015.01.001" @default.
• W1966420007 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4578658" @default.
• W1966420007 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26405687" @default.
• W1966420007 hasPublicationYear "2015" @default.
• W1966420007 type Work @default.
• W1966420007 sameAs 1966420007 @default.
• W1966420007 citedByCount "189" @default.
• W1966420007 countsByYear W19664200072015 @default.
• W1966420007 countsByYear W19664200072016 @default.
• W1966420007 countsByYear W19664200072017 @default.
• W1966420007 countsByYear W19664200072018 @default.
• W1966420007 countsByYear W19664200072019 @default.
• W1966420007 countsByYear W19664200072020 @default.
• W1966420007 countsByYear W19664200072021 @default.
• W1966420007 countsByYear W19664200072022 @default.
• W1966420007 countsByYear W19664200072023 @default.
• W1966420007 crossrefType "journal-article" @default.
• W1966420007 hasAuthorship W1966420007A5019885957 @default.
• W1966420007 hasAuthorship W1966420007A5022825489 @default.
• W1966420007 hasAuthorship W1966420007A5024961838 @default.
• W1966420007 hasAuthorship W1966420007A5026555041 @default.
• W1966420007 hasAuthorship W1966420007A5028258194 @default.
• W1966420007 hasAuthorship W1966420007A5030616812 @default.
• W1966420007 hasAuthorship W1966420007A5031415147 @default.
• W1966420007 hasAuthorship W1966420007A5035211037 @default.
• W1966420007 hasAuthorship W1966420007A5038972103 @default.
• W1966420007 hasAuthorship W1966420007A5055658784 @default.
• W1966420007 hasAuthorship W1966420007A5057250036 @default.
• W1966420007 hasAuthorship W1966420007A5070349336 @default.
• W1966420007 hasAuthorship W1966420007A5071518966 @default.

• next