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• W1966427588 abstract "Insulin resistance in vivo and impaired insulin binding to isolated adipocytes are characteristic of diabetic ketoacidosis in the rat. To determine the respective roles of diabetes and acidaemia in the genesis of the binding defect, insulin binding to adipocytes from alkali-treated ketoacidotic diabetic and ammonium chloride acidotic rats was studed. Reversal of the acidaemia of ketoacidotic rats by sodium bicarbonate infusion (pH 6.73 ± 0.027 to 7.35 ± 0.027, p < 0.001, n = 12) increased adipocyte insulin binding (0.51 ± 0.21% to 2 × 105 cells/ml, n = 6 untreated versus 1.10 ± 0.27% to 2 × 105 cell, n = 6 treated, p < 0.05). Scatchard analysis showed this to be due to an increase in insulin receptor concentration. Ammonium chloride infusion caused marked metabolic acidaemia (pH 6.72 ± 0.04, n = 12) and insulin binding to adipocytes was markedly decreased (0.81 ± 0.12% to 2 × 105 cells/ml n = 6 versus 2.40 ± 0.22% to 2 × 105 cells/ml, n = 6 in controls p < 0.02), due to a change in receptor concentration. The apparent affinity of the receptor was markedly decreased in diabetic animals compared with normal controls but was unchanged in ammonium chloride acidotic animals. Thus in diabetic ketoacidosis there is both decreased affinity and number of insulin receptors partially reversible by prolonged alkali infusion. Only changes in affinity appeared to be specific for the diabetic state." @default.
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• W1966427588 date "1982-06-01" @default.
• W1966427588 modified "2023-10-13" @default.
• W1966427588 title "The effects of metabolic acidosis in vivo on insulin binding to isolated rat adipocytes" @default.
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• W1966427588 doi "https://doi.org/10.1016/0026-0495(82)90094-4" @default.
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