FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966451239> ?p ?o ?g. }

• W1966451239 endingPage "387" @default.
• W1966451239 startingPage "377" @default.
• W1966451239 abstract "Hydra (Cnidaria) is the first animal organism to have developed a neural network, which has been proposed to control, inter alia, the “feeding response”, i.e. a mechanism through which the coelenterate opens and then closes its mouth in the presence of prey and/or glutathione. Here, we report that Hydra contains: (i) selective cannabinoid binding sites; (ii) the endogenous cannabinoid receptor ligand, anandamide (arachidonoylethanolamide); (iii) a fatty acid amide hydrolase-like activity catalysing anandamide hydrolysis; and (iv) the putative biosynthetic precursor of anandamide, N-arachidonoylphosphatidylethanolamine. We suggest that this “endogenous cannabinoid system” is involved in the modulation of the “feeding response”. Anandamide (1 nM–1 μM) potently inhibited (up to 45%) the glutathione-induced “feeding response” by accelerating Hydra vulgaris mouth closure. The effect was maximal at 100 nM anandamide and was reversed by the selective antagonist of the CB1 subtype of mammalian cannabinoid receptors, SR 141716A (50–100 nM). Specific cannabinoid binding sites were detected in membranes from Hydra polyps by using [3H]SR 141716A (Kd=1.87 nM, Bmax=26.7 fmol/mg protein), and increasing anandamide concentrations were found to displace the binding of [3H]SR 141716A to these membranes (Ki=505 nM). Hydra polyps were also found to contain amounts of anandamide (15.6 pmol/g) and N-arachidonoylphosphatidylethanolamine (32.4 pmol/g), as well as the other “endocannabinoid” 2-arachidonoylglycerol (11.2 nmol/g), comparable to those described previously for mammalian brain. Finally, a fatty acid amide hydrolase activity (Vmax=3.4 nmol/min/mg protein), with subcellular distribution, pH dependency and sensitivity to inhibitors similar to those reported for the mammalian enzyme, but with a lower affinity for anandamide (Km=400 μM), was also detected in Hydra polyps. These data suggest that the endocannabinoid signalling system plays a physiological role in Hydra that is to control the feeding response. Hydra is the simplest living organism described so far to use this recently discovered regulatory system." @default.
• W1966451239 created "2016-06-24" @default.
• W1966451239 creator A5000676147 @default.
• W1966451239 creator A5007484138 @default.
• W1966451239 creator A5062572691 @default.
• W1966451239 creator A5076395210 @default.
• W1966451239 creator A5082040442 @default.
• W1966451239 date "1999-08-01" @default.
• W1966451239 modified "2023-09-30" @default.
• W1966451239 title "Finding of the endocannabinoid signalling system in Hydra, a very primitive organism: possible role in the feeding response" @default.
• W1966451239 cites W109761354 @default.
• W1966451239 cites W144044451 @default.
• W1966451239 cites W1469286815 @default.
• W1966451239 cites W172430044 @default.
• W1966451239 cites W1964060433 @default.
• W1966451239 cites W1969338731 @default.
• W1966451239 cites W1976899484 @default.
• W1966451239 cites W1978739151 @default.
• W1966451239 cites W1985882985 @default.
• W1966451239 cites W1987717082 @default.
• W1966451239 cites W1988342389 @default.
• W1966451239 cites W1988371487 @default.
• W1966451239 cites W1990943979 @default.
• W1966451239 cites W2000361888 @default.
• W1966451239 cites W2001972689 @default.
• W1966451239 cites W2002062235 @default.
• W1966451239 cites W2015614945 @default.
• W1966451239 cites W2019993757 @default.
• W1966451239 cites W2020227648 @default.
• W1966451239 cites W2020678194 @default.
• W1966451239 cites W2024653583 @default.
• W1966451239 cites W2027276619 @default.
• W1966451239 cites W2028831542 @default.
• W1966451239 cites W2040944991 @default.
• W1966451239 cites W2048036339 @default.
• W1966451239 cites W2051741667 @default.
• W1966451239 cites W2052643496 @default.
• W1966451239 cites W2056188558 @default.
• W1966451239 cites W2068976751 @default.
• W1966451239 cites W2075894678 @default.
• W1966451239 cites W2082039093 @default.
• W1966451239 cites W2082545082 @default.
• W1966451239 cites W2083371696 @default.
• W1966451239 cites W2087463715 @default.
• W1966451239 cites W2088747149 @default.
• W1966451239 cites W2102941373 @default.
• W1966451239 cites W2108792509 @default.
• W1966451239 cites W2118337917 @default.
• W1966451239 cites W2130948360 @default.
• W1966451239 cites W2134297812 @default.
• W1966451239 cites W2138746099 @default.
• W1966451239 cites W2143573004 @default.
• W1966451239 cites W2144898517 @default.
• W1966451239 cites W2187099245 @default.
• W1966451239 cites W2231575871 @default.
• W1966451239 cites W38196102 @default.
• W1966451239 cites W4211004632 @default.
• W1966451239 doi "https://doi.org/10.1016/s0306-4522(98)00749-0" @default.
• W1966451239 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10392859" @default.
• W1966451239 hasPublicationYear "1999" @default.
• W1966451239 type Work @default.
• W1966451239 sameAs 1966451239 @default.
• W1966451239 citedByCount "153" @default.
• W1966451239 countsByYear W19664512392012 @default.
• W1966451239 countsByYear W19664512392013 @default.
• W1966451239 countsByYear W19664512392014 @default.
• W1966451239 countsByYear W19664512392015 @default.
• W1966451239 countsByYear W19664512392016 @default.
• W1966451239 countsByYear W19664512392017 @default.
• W1966451239 countsByYear W19664512392018 @default.
• W1966451239 countsByYear W19664512392019 @default.
• W1966451239 countsByYear W19664512392020 @default.
• W1966451239 countsByYear W19664512392021 @default.
• W1966451239 countsByYear W19664512392022 @default.
• W1966451239 countsByYear W19664512392023 @default.
• W1966451239 crossrefType "journal-article" @default.
• W1966451239 hasAuthorship W1966451239A5000676147 @default.
• W1966451239 hasAuthorship W1966451239A5007484138 @default.
• W1966451239 hasAuthorship W1966451239A5062572691 @default.
• W1966451239 hasAuthorship W1966451239A5076395210 @default.
• W1966451239 hasAuthorship W1966451239A5082040442 @default.
• W1966451239 hasConcept C135285700 @default.
• W1966451239 hasConcept C148001335 @default.
• W1966451239 hasConcept C170493617 @default.
• W1966451239 hasConcept C185592680 @default.
• W1966451239 hasConcept C2776885963 @default.
• W1966451239 hasConcept C2779783865 @default.
• W1966451239 hasConcept C2780100140 @default.
• W1966451239 hasConcept C2780871563 @default.
• W1966451239 hasConcept C2781144285 @default.
• W1966451239 hasConcept C34781881 @default.
• W1966451239 hasConcept C46721173 @default.
• W1966451239 hasConcept C55493867 @default.
• W1966451239 hasConcept C86803240 @default.
• W1966451239 hasConcept C95444343 @default.
• W1966451239 hasConceptScore W1966451239C135285700 @default.
• W1966451239 hasConceptScore W1966451239C148001335 @default.
• W1966451239 hasConceptScore W1966451239C170493617 @default.

• next