Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966451882> ?p ?o ?g. }
- W1966451882 endingPage "2980" @default.
- W1966451882 startingPage "2972" @default.
- W1966451882 abstract "Epigallocatechin-3-gallate (EGCG), the most abundant polyphenol in green tea extract, has been found to have anticancer activities in various types of cancer. However, the underlying mechanisms are not completely clear. In the present study, the effects of EGCG on migration, invasion, angiogenesis and epithelial-mesenchymal transition (EMT) induced by nicotine in A549 non-small cell lung cancer (NSCLC) cells were investigated, and the underlying molecular mechanisms were preliminarily examined. The results showed that different concentrations of EGCG significantly inhibited nicotine-induced migration and invasion. Moreover, EGCG reversed the upregulation of HIF-1α, vascular endothelial growth factor (VEGF), COX-2, p-Akt, p-ERK and vimentin protein levels and the downregulation of p53 and β-catenin protein levels mediated by nicotine in A549 cells, but had no significant effect on their mRNA levels. Furthermore, EGCG markedly inhibited HIF-1α-dependent angiogenesis induced by nicotine in vitro and in vivo, and suppressed HIF-1α and VEGF protein expression induced by nicotine in A549 xenografts of nude mice. Taken together, the results indicated that EGCG inhibited nicotine-induced angiogenesis and EMT, leading to migration and invasion in A549 cells. The results of the present study suggested that EGCG can be developed into a potential agent for the prevention and treatment of smoking-associated NSCLC." @default.
- W1966451882 created "2016-06-24" @default.
- W1966451882 creator A5009338657 @default.
- W1966451882 creator A5021687717 @default.
- W1966451882 creator A5044873446 @default.
- W1966451882 creator A5048279362 @default.
- W1966451882 creator A5074963172 @default.
- W1966451882 creator A5081244944 @default.
- W1966451882 date "2015-03-31" @default.
- W1966451882 modified "2023-10-14" @default.
- W1966451882 title "Epigallocatechin-3-gallate inhibits nicotine-induced migration and invasion by the suppression of angiogenesis and epithelial-mesenchymal transition in non-small cell lung cancer cells" @default.
- W1966451882 cites W153368653 @default.
- W1966451882 cites W1560380872 @default.
- W1966451882 cites W1965355050 @default.
- W1966451882 cites W1966837531 @default.
- W1966451882 cites W1977849174 @default.
- W1966451882 cites W1979840121 @default.
- W1966451882 cites W1988284275 @default.
- W1966451882 cites W1995807694 @default.
- W1966451882 cites W1998349950 @default.
- W1966451882 cites W2008854828 @default.
- W1966451882 cites W2012114049 @default.
- W1966451882 cites W2012123152 @default.
- W1966451882 cites W2013264638 @default.
- W1966451882 cites W2013580446 @default.
- W1966451882 cites W2021585018 @default.
- W1966451882 cites W2026294697 @default.
- W1966451882 cites W2029151357 @default.
- W1966451882 cites W2036045707 @default.
- W1966451882 cites W2039983741 @default.
- W1966451882 cites W2041732315 @default.
- W1966451882 cites W2044317336 @default.
- W1966451882 cites W2046847797 @default.
- W1966451882 cites W2047961451 @default.
- W1966451882 cites W2049611896 @default.
- W1966451882 cites W2056548559 @default.
- W1966451882 cites W2056751212 @default.
- W1966451882 cites W2059245515 @default.
- W1966451882 cites W2064412032 @default.
- W1966451882 cites W2066336418 @default.
- W1966451882 cites W2078427819 @default.
- W1966451882 cites W2083011076 @default.
- W1966451882 cites W2087776976 @default.
- W1966451882 cites W2091068407 @default.
- W1966451882 cites W2095510412 @default.
- W1966451882 cites W2108646620 @default.
- W1966451882 cites W2111226655 @default.
- W1966451882 cites W2119490571 @default.
- W1966451882 cites W2120364751 @default.
- W1966451882 cites W2125552828 @default.
- W1966451882 cites W2127778851 @default.
- W1966451882 cites W2145002455 @default.
- W1966451882 cites W2157559115 @default.
- W1966451882 cites W2161409865 @default.
- W1966451882 cites W2161472990 @default.
- W1966451882 cites W2163490818 @default.
- W1966451882 cites W2166893909 @default.
- W1966451882 cites W2168456538 @default.
- W1966451882 doi "https://doi.org/10.3892/or.2015.3889" @default.
- W1966451882 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25845434" @default.
- W1966451882 hasPublicationYear "2015" @default.
- W1966451882 type Work @default.
- W1966451882 sameAs 1966451882 @default.
- W1966451882 citedByCount "81" @default.
- W1966451882 countsByYear W19664518822015 @default.
- W1966451882 countsByYear W19664518822016 @default.
- W1966451882 countsByYear W19664518822017 @default.
- W1966451882 countsByYear W19664518822018 @default.
- W1966451882 countsByYear W19664518822019 @default.
- W1966451882 countsByYear W19664518822020 @default.
- W1966451882 countsByYear W19664518822021 @default.
- W1966451882 countsByYear W19664518822022 @default.
- W1966451882 countsByYear W19664518822023 @default.
- W1966451882 crossrefType "journal-article" @default.
- W1966451882 hasAuthorship W1966451882A5009338657 @default.
- W1966451882 hasAuthorship W1966451882A5021687717 @default.
- W1966451882 hasAuthorship W1966451882A5044873446 @default.
- W1966451882 hasAuthorship W1966451882A5048279362 @default.
- W1966451882 hasAuthorship W1966451882A5074963172 @default.
- W1966451882 hasAuthorship W1966451882A5081244944 @default.
- W1966451882 hasBestOaLocation W19664518821 @default.
- W1966451882 hasConcept C104317684 @default.
- W1966451882 hasConcept C127561419 @default.
- W1966451882 hasConcept C137738243 @default.
- W1966451882 hasConcept C147447768 @default.
- W1966451882 hasConcept C1491633281 @default.
- W1966451882 hasConcept C167734588 @default.
- W1966451882 hasConcept C169760540 @default.
- W1966451882 hasConcept C185592680 @default.
- W1966451882 hasConcept C203014093 @default.
- W1966451882 hasConcept C204232928 @default.
- W1966451882 hasConcept C2777025900 @default.
- W1966451882 hasConcept C2777192995 @default.
- W1966451882 hasConcept C2778004101 @default.
- W1966451882 hasConcept C2779547902 @default.
- W1966451882 hasConcept C2780394083 @default.
- W1966451882 hasConcept C502942594 @default.
- W1966451882 hasConcept C55493867 @default.