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- W1966454764 abstract "Cardiac abnormalities including cardiomyopathy, altered diastolic function and congenital heart disease have been described in infants of diabetic mothers. It has been shown that control of maternal diabetes has a direct influence on the incidence of these complications. In order to determine whether treatment of A2 diabetic mothers with insulin will have added beneficial effect on neonatal cardiac outcome, sixty A2 diabetic subjects were randomly controlled with either diet or insulin during pregnancy. Forty-eight infants of these diabetic mothers (25 from the insulin group, 23 from the diet group) underwent echocardiographic examination during the first 48 hours of life, including M-mode, two-dimensional imaging, and pulsed Doppler interrogation using a 5 Mhz transducer. Variables included heart rate, cardiac anatomy, ventricular wall thickness, left atrial (LA) and ascending aorta (Aao) in diastole. Pulsed wave Doppler interrogation of tricuspid and mitral valve inflows were recorded to measure peak E and A velocities, E deceleration half time, and area under E and A portions of the diastolic velocity-time integral. Pulsed Doppler interrogation at aortic outflow was obtained to measure peak interventricular septal thickness/left ventricular posterior wall thickness, left ventricular ejection fraction, E/A, and cardiac index." @default.
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- W1966454764 date "1996-04-01" @default.
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- W1966454764 title "CARDIOMYOPATHY IN INFANTS OF A2 DIABETIC MOTHERS: AN ECHOCARDIOGRAPHIC STUDY. 111" @default.
- W1966454764 doi "https://doi.org/10.1203/00006450-199604001-00130" @default.
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