FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966454970> ?p ?o ?g. }

• W1966454970 endingPage "2387" @default.
• W1966454970 startingPage "2379" @default.
• W1966454970 abstract "Determinants of the Fe−CO and C−O stretching frequencies in (imidazole)heme−CO adducts have been investigated via density functional theory (DFT) analysis, in connection with puzzling characteristics of the heme sensor protein CooA and of the H−NOX (Heme−Nitric Oxide and/or OXygen binding) family of proteins, including soluble guanylate cyclase (sGC). The computations show that two mechanisms of Fe−histidine bond weakening have opposite effects on the νFeC/νCO pattern. Mechanical tension is expected to raise νFeC with little change in νCO whereas the weakening of H-bond donation from the imidazole ligand has the opposite effect. Data on CooA indicate imidazole H-bond weakening associated with heme displacement, as part of the activation mechanism. The computations also reveal that protein-induced distortion of the porphyrin ring, a prominent structural feature of the H−NOX protein TtTar4H (Thermoanaerobacter tengcongensis Tar4 protein heme domain), has surprisingly little effect on νFeC or νCO. However, another structural feature, strong H-bonding to the propionates, is suggested to account for the weakened back bonding that is evident in sGC. TtTar4H−CO itself has an elevated νFeC, which is successfully modeled as a compression effect, resulting from steric crowding in the distal pocket. νFeC/νCO data, in conjunction with modeling, can provide valuable insight into mechanisms for heme-protein modulation." @default.
• W1966454970 created "2016-06-24" @default.
• W1966454970 creator A5035122688 @default.
• W1966454970 creator A5070326580 @default.
• W1966454970 creator A5058447268 @default.
• W1966454970 date "2008-01-25" @default.
• W1966454970 modified "2023-10-10" @default.
• W1966454970 title "DFT Analysis of Axial and Equatorial Effects on Heme−CO Vibrational Modes: Applications to CooA and H−NOX Heme Sensor Proteins" @default.
• W1966454970 cites W1575373997 @default.
• W1966454970 cites W1966165983 @default.
• W1966454970 cites W1968203296 @default.
• W1966454970 cites W1970441651 @default.
• W1966454970 cites W1991861960 @default.
• W1966454970 cites W1993427153 @default.
• W1966454970 cites W2025012109 @default.
• W1966454970 cites W2033974481 @default.
• W1966454970 cites W2034549650 @default.
• W1966454970 cites W2035163326 @default.
• W1966454970 cites W2049061162 @default.
• W1966454970 cites W2054881399 @default.
• W1966454970 cites W2068124482 @default.
• W1966454970 cites W2068228867 @default.
• W1966454970 cites W2079852793 @default.
• W1966454970 cites W2096078580 @default.
• W1966454970 cites W2098819169 @default.
• W1966454970 doi "https://doi.org/10.1021/bi702254y" @default.
• W1966454970 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2754214" @default.
• W1966454970 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18217776" @default.
• W1966454970 hasPublicationYear "2008" @default.
• W1966454970 type Work @default.
• W1966454970 sameAs 1966454970 @default.
• W1966454970 citedByCount "33" @default.
• W1966454970 countsByYear W19664549702012 @default.
• W1966454970 countsByYear W19664549702013 @default.
• W1966454970 countsByYear W19664549702014 @default.
• W1966454970 countsByYear W19664549702015 @default.
• W1966454970 countsByYear W19664549702019 @default.
• W1966454970 crossrefType "journal-article" @default.
• W1966454970 hasAuthorship W1966454970A5035122688 @default.
• W1966454970 hasAuthorship W1966454970A5058447268 @default.
• W1966454970 hasAuthorship W1966454970A5070326580 @default.
• W1966454970 hasBestOaLocation W19664549702 @default.
• W1966454970 hasConcept C116569031 @default.
• W1966454970 hasConcept C170493617 @default.
• W1966454970 hasConcept C173803235 @default.
• W1966454970 hasConcept C178790620 @default.
• W1966454970 hasConcept C181199279 @default.
• W1966454970 hasConcept C185592680 @default.
• W1966454970 hasConcept C201194858 @default.
• W1966454970 hasConcept C20705724 @default.
• W1966454970 hasConcept C2776217839 @default.
• W1966454970 hasConcept C2778460671 @default.
• W1966454970 hasConcept C2778827303 @default.
• W1966454970 hasConcept C2779400197 @default.
• W1966454970 hasConcept C2779480358 @default.
• W1966454970 hasConcept C2780874372 @default.
• W1966454970 hasConcept C515207424 @default.
• W1966454970 hasConcept C519581460 @default.
• W1966454970 hasConcept C55493867 @default.
• W1966454970 hasConcept C71240020 @default.
• W1966454970 hasConcept C75473681 @default.
• W1966454970 hasConcept C8010536 @default.
• W1966454970 hasConceptScore W1966454970C116569031 @default.
• W1966454970 hasConceptScore W1966454970C170493617 @default.
• W1966454970 hasConceptScore W1966454970C173803235 @default.
• W1966454970 hasConceptScore W1966454970C178790620 @default.
• W1966454970 hasConceptScore W1966454970C181199279 @default.
• W1966454970 hasConceptScore W1966454970C185592680 @default.
• W1966454970 hasConceptScore W1966454970C201194858 @default.
• W1966454970 hasConceptScore W1966454970C20705724 @default.
• W1966454970 hasConceptScore W1966454970C2776217839 @default.
• W1966454970 hasConceptScore W1966454970C2778460671 @default.
• W1966454970 hasConceptScore W1966454970C2778827303 @default.
• W1966454970 hasConceptScore W1966454970C2779400197 @default.
• W1966454970 hasConceptScore W1966454970C2779480358 @default.
• W1966454970 hasConceptScore W1966454970C2780874372 @default.
• W1966454970 hasConceptScore W1966454970C515207424 @default.
• W1966454970 hasConceptScore W1966454970C519581460 @default.
• W1966454970 hasConceptScore W1966454970C55493867 @default.
• W1966454970 hasConceptScore W1966454970C71240020 @default.
• W1966454970 hasConceptScore W1966454970C75473681 @default.
• W1966454970 hasConceptScore W1966454970C8010536 @default.
• W1966454970 hasIssue "8" @default.
• W1966454970 hasLocation W19664549701 @default.
• W1966454970 hasLocation W19664549702 @default.
• W1966454970 hasLocation W19664549703 @default.
• W1966454970 hasLocation W19664549704 @default.
• W1966454970 hasOpenAccess W1966454970 @default.
• W1966454970 hasPrimaryLocation W19664549701 @default.
• W1966454970 hasRelatedWork W1998183079 @default.
• W1966454970 hasRelatedWork W2041935468 @default.
• W1966454970 hasRelatedWork W2105822876 @default.
• W1966454970 hasRelatedWork W2328446497 @default.
• W1966454970 hasRelatedWork W2328841418 @default.
• W1966454970 hasRelatedWork W2437153424 @default.
• W1966454970 hasRelatedWork W2585296264 @default.
• W1966454970 hasRelatedWork W2951833734 @default.
• W1966454970 hasRelatedWork W3192433570 @default.

• next