Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966460887> ?p ?o ?g. }
- W1966460887 endingPage "1443" @default.
- W1966460887 startingPage "1433" @default.
- W1966460887 abstract "B-cell chronic lymphocytic leukemia (CLL), which is the most common lymphoproliferative disorder, displays characteristics consistent with a defect in programmed cell death and exhibit prolonged survival of affected cells in vivo. When recovered from peripheral blood or lymphoid tissues of patients and cultured in vitro, CLL malignant cells rapidly undergo spontaneous apoptosis. CLL B-cells co-culture with different adherent cell types, collectively referred to as stromal cells, induces leukemia cell survival, migration, and drug resistance. In addition, such survival-promoting microenvironments can rescue leukemia cells from cytotoxic therapy, giving way to disease relapse. Quite surprisingly considering that many anti-cancer drugs, including γ-secretase inhibitors, Cyclopamine and Quercetin, were reported to block Notch, Wnt, and Hedgehog anti-apoptotic signaling pathways respectively, the link between the latter anti-apoptotic pathways and bone marrow stromal cells in CLL has been pointed out only recently. Data concerning the pathogenesis of CLL have been critically reviewed in regards to the growing body of evidence indicating deregulations of Notch, Wnt and Hedgehog anti-apoptotic signaling pathways in the stromal microenvironment of affected cells." @default.
- W1966460887 created "2016-06-24" @default.
- W1966460887 creator A5008655895 @default.
- W1966460887 creator A5040839479 @default.
- W1966460887 creator A5084804501 @default.
- W1966460887 date "2012-07-01" @default.
- W1966460887 modified "2023-10-18" @default.
- W1966460887 title "Interactions between bone marrow stromal microenvironment and B-chronic lymphocytic leukemia cells: Any role for Notch, Wnt and Hh signaling pathways?" @default.
- W1966460887 cites W115619992 @default.
- W1966460887 cites W1492263161 @default.
- W1966460887 cites W1494511436 @default.
- W1966460887 cites W1531083786 @default.
- W1966460887 cites W1553484215 @default.
- W1966460887 cites W1581730303 @default.
- W1966460887 cites W1596473475 @default.
- W1966460887 cites W1723444490 @default.
- W1966460887 cites W1787830524 @default.
- W1966460887 cites W1838957180 @default.
- W1966460887 cites W1873031565 @default.
- W1966460887 cites W1908445283 @default.
- W1966460887 cites W1963493384 @default.
- W1966460887 cites W1963687548 @default.
- W1966460887 cites W1965431780 @default.
- W1966460887 cites W1967825122 @default.
- W1966460887 cites W1969008892 @default.
- W1966460887 cites W1971436806 @default.
- W1966460887 cites W1974433801 @default.
- W1966460887 cites W1975104394 @default.
- W1966460887 cites W1975301877 @default.
- W1966460887 cites W1975323271 @default.
- W1966460887 cites W1975853332 @default.
- W1966460887 cites W1976767301 @default.
- W1966460887 cites W1978881608 @default.
- W1966460887 cites W1979822739 @default.
- W1966460887 cites W1982023788 @default.
- W1966460887 cites W1992387962 @default.
- W1966460887 cites W1993986769 @default.
- W1966460887 cites W1997187693 @default.
- W1966460887 cites W1997905438 @default.
- W1966460887 cites W1999316583 @default.
- W1966460887 cites W1999500450 @default.
- W1966460887 cites W2001957066 @default.
- W1966460887 cites W2006868797 @default.
- W1966460887 cites W2007710816 @default.
- W1966460887 cites W2008295869 @default.
- W1966460887 cites W2009626854 @default.
- W1966460887 cites W2010547317 @default.
- W1966460887 cites W2011250979 @default.
- W1966460887 cites W2012757901 @default.
- W1966460887 cites W2013691481 @default.
- W1966460887 cites W2015486137 @default.
- W1966460887 cites W2018531061 @default.
- W1966460887 cites W2018632262 @default.
- W1966460887 cites W2020467756 @default.
- W1966460887 cites W2023192965 @default.
- W1966460887 cites W2025748388 @default.
- W1966460887 cites W2025985513 @default.
- W1966460887 cites W2026384230 @default.
- W1966460887 cites W2029143606 @default.
- W1966460887 cites W2031380629 @default.
- W1966460887 cites W2036333108 @default.
- W1966460887 cites W2038053631 @default.
- W1966460887 cites W2038661420 @default.
- W1966460887 cites W2044826816 @default.
- W1966460887 cites W2045106437 @default.
- W1966460887 cites W2048788975 @default.
- W1966460887 cites W2049229611 @default.
- W1966460887 cites W2050273417 @default.
- W1966460887 cites W2050599075 @default.
- W1966460887 cites W2050749151 @default.
- W1966460887 cites W2052661123 @default.
- W1966460887 cites W2058594499 @default.
- W1966460887 cites W2058734213 @default.
- W1966460887 cites W2060710804 @default.
- W1966460887 cites W2067395489 @default.
- W1966460887 cites W2068959270 @default.
- W1966460887 cites W2069164984 @default.
- W1966460887 cites W2070793750 @default.
- W1966460887 cites W2073560608 @default.
- W1966460887 cites W2075971846 @default.
- W1966460887 cites W2076114806 @default.
- W1966460887 cites W2076940668 @default.
- W1966460887 cites W2081170157 @default.
- W1966460887 cites W2084448746 @default.
- W1966460887 cites W2084454660 @default.
- W1966460887 cites W2085021251 @default.
- W1966460887 cites W2086790430 @default.
- W1966460887 cites W2087635788 @default.
- W1966460887 cites W2088811912 @default.
- W1966460887 cites W2091515725 @default.
- W1966460887 cites W2091891304 @default.
- W1966460887 cites W2093659327 @default.
- W1966460887 cites W2098251773 @default.
- W1966460887 cites W2099118069 @default.
- W1966460887 cites W2104551938 @default.
- W1966460887 cites W2109515409 @default.
- W1966460887 cites W2110425490 @default.
- W1966460887 cites W2114649348 @default.