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- W1966469610 abstract "Abstract An attempt was made to discover why intravenous d -lysergic acid diethylamide (LSD) selectively inhibits the firing rate of raphe neurones recorded in the midbrain of anaesthetised rats. The results indicate that midbrain raphe neurones are more sensitive to the depressant action of microiontophoretically applied 5-hydroxytryptamine than other neurones within the midbrain. When administered in small intravenous doses (8–20 μg/kg), or at low microiontophoretic currents, LSD selectively inhibited raphe unit firing within the midbrain. Higher intravenous doses (40 μg/kg) or larger microiontophoretic applications also led to the partial inhibition of non-raphe unit firing. It is suggested that LSD may act as an agonist on the inhibitory 5-hydroxytryptamine receptor in addition to being an antagonist at excitatory 5-hydroxytryptamine receptors." @default.
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- W1966469610 title "Responses of midbrain neurones to micro-iontophoretically applied 5-hydroxytryptamine: Comparison with the response to intravenously administered lysergic acid diethylamide" @default.
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- W1966469610 doi "https://doi.org/10.1016/0028-3908(76)90055-1" @default.
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