FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966471617> ?p ?o ?g. }

• W1966471617 endingPage "346" @default.
• W1966471617 startingPage "329" @default.
• W1966471617 abstract "In order to investigate the distribution of epitopes recognized by T-cell clones directed against HLA class II products, bulk primed cell populations were generated using cells matched for class I determinants but disparate for class II determinants. Cells were cloned by single cell deposition (FACS IV) or limiting dilution (1 cell/3 wells), and assayed for proliferative and cytolytic function with panels of well-characterized cells. All cytolytic clones generated from an anti-DR4/Dw4/DQw3 priming combination or an anti-DR2/Dw2/DQw1 priming combination lysed essentially all targets sharing the same Dw type as the sensitizing cell. In some cases, other targets were also lysed. For instance, some clones were lytic to targets bearing the same DR antigen but another Dw subtype including a few clones lytic to virtually all cells carrying that DR specificity. An occasional target cell expressing a different DR antigen from the sensitizing cell was also lysed by these clones, in some cases to the same extent of lysis seen on the specific target. Monoclonal antibody inhibition studies identified three groups of clones: the DQ directed clones and clones apparently directed at more than one DR product. However, the number of molecules detected for each haplotype remains to be investigated. Our data indicate that determinants detected on both DR and DQ products are associated with the Dw type of the sensitizing cell showing that there is polymorphism recognized by T cells on both DR and DQ that is subtypic to the serologically defined specificities. Thus, it appears that the bulk T-cell response is a composite of individual clones recognizing distinct determinants on these class II molecules. The implications of these findings for studies of HLA restricted recognition are discussed." @default.
• W1966471617 created "2016-06-24" @default.
• W1966471617 creator A5047499121 @default.
• W1966471617 creator A5050787140 @default.
• W1966471617 date "1986-08-01" @default.
• W1966471617 modified "2023-10-16" @default.
• W1966471617 title "Clonal analysis of HLA-DR and -DQ associated determinants: Their contribution to Dw specificities" @default.
• W1966471617 cites W1483035379 @default.
• W1966471617 cites W1569549749 @default.
• W1966471617 cites W1955268145 @default.
• W1966471617 cites W1967433346 @default.
• W1966471617 cites W1977472316 @default.
• W1966471617 cites W1979922184 @default.
• W1966471617 cites W1988167843 @default.
• W1966471617 cites W1995211434 @default.
• W1966471617 cites W1996383109 @default.
• W1966471617 cites W1999235534 @default.
• W1966471617 cites W2007009032 @default.
• W1966471617 cites W2022181875 @default.
• W1966471617 cites W2026970642 @default.
• W1966471617 cites W2037571846 @default.
• W1966471617 cites W2041363306 @default.
• W1966471617 cites W2045224597 @default.
• W1966471617 cites W2046095019 @default.
• W1966471617 cites W2060055097 @default.
• W1966471617 cites W2075337242 @default.
• W1966471617 cites W2082541413 @default.
• W1966471617 cites W2149435172 @default.
• W1966471617 cites W2164590616 @default.
• W1966471617 cites W2232494439 @default.
• W1966471617 cites W2311523387 @default.
• W1966471617 cites W2329767789 @default.
• W1966471617 doi "https://doi.org/10.1016/0198-8859(86)90060-1" @default.
• W1966471617 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2428780" @default.
• W1966471617 hasPublicationYear "1986" @default.
• W1966471617 type Work @default.
• W1966471617 sameAs 1966471617 @default.
• W1966471617 citedByCount "30" @default.
• W1966471617 crossrefType "journal-article" @default.
• W1966471617 hasAuthorship W1966471617A5047499121 @default.
• W1966471617 hasAuthorship W1966471617A5050787140 @default.
• W1966471617 hasConcept C100701293 @default.
• W1966471617 hasConcept C147483822 @default.
• W1966471617 hasConcept C153911025 @default.
• W1966471617 hasConcept C154317977 @default.
• W1966471617 hasConcept C159047783 @default.
• W1966471617 hasConcept C159654299 @default.
• W1966471617 hasConcept C182615771 @default.
• W1966471617 hasConcept C188280979 @default.
• W1966471617 hasConcept C195616568 @default.
• W1966471617 hasConcept C202751555 @default.
• W1966471617 hasConcept C207936829 @default.
• W1966471617 hasConcept C2522874641 @default.
• W1966471617 hasConcept C2776090121 @default.
• W1966471617 hasConcept C542903549 @default.
• W1966471617 hasConcept C54355233 @default.
• W1966471617 hasConcept C57409179 @default.
• W1966471617 hasConcept C59822182 @default.
• W1966471617 hasConcept C73588182 @default.
• W1966471617 hasConcept C81444415 @default.
• W1966471617 hasConcept C86803240 @default.
• W1966471617 hasConcept C8891405 @default.
• W1966471617 hasConceptScore W1966471617C100701293 @default.
• W1966471617 hasConceptScore W1966471617C147483822 @default.
• W1966471617 hasConceptScore W1966471617C153911025 @default.
• W1966471617 hasConceptScore W1966471617C154317977 @default.
• W1966471617 hasConceptScore W1966471617C159047783 @default.
• W1966471617 hasConceptScore W1966471617C159654299 @default.
• W1966471617 hasConceptScore W1966471617C182615771 @default.
• W1966471617 hasConceptScore W1966471617C188280979 @default.
• W1966471617 hasConceptScore W1966471617C195616568 @default.
• W1966471617 hasConceptScore W1966471617C202751555 @default.
• W1966471617 hasConceptScore W1966471617C207936829 @default.
• W1966471617 hasConceptScore W1966471617C2522874641 @default.
• W1966471617 hasConceptScore W1966471617C2776090121 @default.
• W1966471617 hasConceptScore W1966471617C542903549 @default.
• W1966471617 hasConceptScore W1966471617C54355233 @default.
• W1966471617 hasConceptScore W1966471617C57409179 @default.
• W1966471617 hasConceptScore W1966471617C59822182 @default.
• W1966471617 hasConceptScore W1966471617C73588182 @default.
• W1966471617 hasConceptScore W1966471617C81444415 @default.
• W1966471617 hasConceptScore W1966471617C86803240 @default.
• W1966471617 hasConceptScore W1966471617C8891405 @default.
• W1966471617 hasIssue "4" @default.
• W1966471617 hasLocation W19664716171 @default.
• W1966471617 hasLocation W19664716172 @default.
• W1966471617 hasOpenAccess W1966471617 @default.
• W1966471617 hasPrimaryLocation W19664716171 @default.
• W1966471617 hasRelatedWork W1550728793 @default.
• W1966471617 hasRelatedWork W1554592432 @default.
• W1966471617 hasRelatedWork W1573436053 @default.
• W1966471617 hasRelatedWork W1604248381 @default.
• W1966471617 hasRelatedWork W2001280522 @default.
• W1966471617 hasRelatedWork W2042008525 @default.
• W1966471617 hasRelatedWork W2092720945 @default.
• W1966471617 hasRelatedWork W2101049085 @default.
• W1966471617 hasRelatedWork W2106670663 @default.
• W1966471617 hasRelatedWork W2787762602 @default.

• next