Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966483140> ?p ?o ?g. }
- W1966483140 endingPage "e1003473" @default.
- W1966483140 startingPage "e1003473" @default.
- W1966483140 abstract "SUMOylation participates in ecdysteroid biosynthesis at the onset of metamorphosis in Drosophila melanogaster. Silencing the Drosophila SUMO homologue smt3 in the prothoracic gland leads to reduced lipid content, low ecdysone titers, and a block in the larval-pupal transition. Here we show that the SR-BI family of Scavenger Receptors mediates SUMO functions. Reduced levels of Snmp1 compromise lipid uptake in the prothoracic gland. In addition, overexpression of Snmp1 is able to recover lipid droplet levels in the smt3 knockdown prothoracic gland cells. Snmp1 expression depends on Ftz-f1 (an NR5A-type orphan nuclear receptor), the expression of which, in turn, depends on SUMO. Furthermore, we show by in vitro and in vivo experiments that Ftz-f1 is SUMOylated. RNAi-mediated knockdown of ftz-f1 phenocopies that of smt3 at the larval to pupal transition, thus Ftz-f1 is an interesting candidate to mediate some of the functions of SUMO at the onset of metamorphosis. Additionally, we demonstrate that the role of SUMOylation, Ftz-f1, and the Scavenger Receptors in lipid capture and mobilization is conserved in other steroidogenic tissues such as the follicle cells of the ovary. smt3 knockdown, as well as ftz-f1 or Scavenger knockdown, depleted the lipid content of the follicle cells, which could be rescued by Snmp1 overexpression. Therefore, our data provide new insights into the regulation of metamorphosis via lipid homeostasis, showing that Drosophila Smt3, Ftz-f1, and SR-BIs are part of a general mechanism for uptake of lipids such as cholesterol, required during development in steroidogenic tissues." @default.
- W1966483140 created "2016-06-24" @default.
- W1966483140 creator A5006322147 @default.
- W1966483140 creator A5006502512 @default.
- W1966483140 creator A5007028831 @default.
- W1966483140 creator A5012180081 @default.
- W1966483140 creator A5013880116 @default.
- W1966483140 creator A5016998574 @default.
- W1966483140 creator A5023273311 @default.
- W1966483140 creator A5036819711 @default.
- W1966483140 creator A5055330349 @default.
- W1966483140 creator A5068389219 @default.
- W1966483140 creator A5074486047 @default.
- W1966483140 date "2013-04-18" @default.
- W1966483140 modified "2023-10-04" @default.
- W1966483140 title "Scavenger Receptors Mediate the Role of SUMO and Ftz-f1 in Drosophila Steroidogenesis" @default.
- W1966483140 cites W127498259 @default.
- W1966483140 cites W179351008 @default.
- W1966483140 cites W1888220027 @default.
- W1966483140 cites W1963828768 @default.
- W1966483140 cites W1966598605 @default.
- W1966483140 cites W1968932054 @default.
- W1966483140 cites W1969313934 @default.
- W1966483140 cites W1969852276 @default.
- W1966483140 cites W1971188096 @default.
- W1966483140 cites W1971308325 @default.
- W1966483140 cites W1971528214 @default.
- W1966483140 cites W1972364582 @default.
- W1966483140 cites W1974663161 @default.
- W1966483140 cites W1975662382 @default.
- W1966483140 cites W1975778067 @default.
- W1966483140 cites W1986687376 @default.
- W1966483140 cites W1995003722 @default.
- W1966483140 cites W1995940055 @default.
- W1966483140 cites W1998861353 @default.
- W1966483140 cites W1999057135 @default.
- W1966483140 cites W2000441118 @default.
- W1966483140 cites W2000519009 @default.
- W1966483140 cites W2001568722 @default.
- W1966483140 cites W2004660622 @default.
- W1966483140 cites W2004805723 @default.
- W1966483140 cites W2006313941 @default.
- W1966483140 cites W2008297562 @default.
- W1966483140 cites W2009177498 @default.
- W1966483140 cites W2010154023 @default.
- W1966483140 cites W2012257160 @default.
- W1966483140 cites W2013153343 @default.
- W1966483140 cites W2015882117 @default.
- W1966483140 cites W2016794456 @default.
- W1966483140 cites W2023711636 @default.
- W1966483140 cites W2024540694 @default.
- W1966483140 cites W2024878978 @default.
- W1966483140 cites W2027931693 @default.
- W1966483140 cites W2028497702 @default.
- W1966483140 cites W2029196830 @default.
- W1966483140 cites W2030131753 @default.
- W1966483140 cites W2031090055 @default.
- W1966483140 cites W2032621098 @default.
- W1966483140 cites W2033014520 @default.
- W1966483140 cites W2036498884 @default.
- W1966483140 cites W2042171464 @default.
- W1966483140 cites W2044800513 @default.
- W1966483140 cites W2045700225 @default.
- W1966483140 cites W2048163544 @default.
- W1966483140 cites W2049493804 @default.
- W1966483140 cites W2052067930 @default.
- W1966483140 cites W2052112605 @default.
- W1966483140 cites W2053523004 @default.
- W1966483140 cites W2054478667 @default.
- W1966483140 cites W2055350011 @default.
- W1966483140 cites W2057140490 @default.
- W1966483140 cites W2057493134 @default.
- W1966483140 cites W2058522782 @default.
- W1966483140 cites W2059556039 @default.
- W1966483140 cites W2061795728 @default.
- W1966483140 cites W2063689436 @default.
- W1966483140 cites W2064686852 @default.
- W1966483140 cites W2067172471 @default.
- W1966483140 cites W2069027872 @default.
- W1966483140 cites W2072255567 @default.
- W1966483140 cites W2072712583 @default.
- W1966483140 cites W2076467199 @default.
- W1966483140 cites W2077271480 @default.
- W1966483140 cites W2078806857 @default.
- W1966483140 cites W2081171673 @default.
- W1966483140 cites W2081444027 @default.
- W1966483140 cites W2082245375 @default.
- W1966483140 cites W2084811410 @default.
- W1966483140 cites W2085138441 @default.
- W1966483140 cites W2088695563 @default.
- W1966483140 cites W2090490326 @default.
- W1966483140 cites W2092328338 @default.
- W1966483140 cites W2098470591 @default.
- W1966483140 cites W2101972384 @default.
- W1966483140 cites W2103080800 @default.
- W1966483140 cites W2109286448 @default.
- W1966483140 cites W2109882125 @default.
- W1966483140 cites W2110256914 @default.