Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966501464> ?p ?o ?g. }
- W1966501464 endingPage "66" @default.
- W1966501464 startingPage "55" @default.
- W1966501464 abstract "Summary: The Drosophila homeobox gene tinman plays a critical role in subdividing the early mesoderm. In particular, tinman is absolutely required for formation of the heart and visceral mesoderm. tinman expression is initiated throughout the mesoderm of the trunk region under the control of the bHLH transcription factor encoded by the twist gene, a determinant of all mesoderm. Later, tinman expression is restricted to the dorsal portion of the mesoderm, a process that is directed by decapentaplegic (dpp) whose product (a TGF-β-related protein) is secreted by the overlaying ectoderm. Further restriction of tinman expression to the cardiac progenitors, in which it will persist throughout development, involves the secreted segmentation gene product encoded by wingless (wg, a Drosophila Wnt gene). Here, we show that strong early expression depends on the synergistic action of an enhancer element at the 5′ end of the gene in conjunction with an element in the first intron. Moreover, two distinct enhancer regions are responsible for tinman expression in the heart: one region confers expression in the heat tube associated pericardial cells, the other element drives expression in the contractile, myocardial cells. The latter element contains two CREB consensus binding sites that are essential for cardiac-specific expression. genesis 26:55–66, 2000. © 2000 Wiley-Liss, Inc." @default.
- W1966501464 created "2016-06-24" @default.
- W1966501464 creator A5038705827 @default.
- W1966501464 creator A5039497404 @default.
- W1966501464 creator A5040882990 @default.
- W1966501464 creator A5049253881 @default.
- W1966501464 creator A5052631122 @default.
- W1966501464 creator A5070873780 @default.
- W1966501464 creator A5087552055 @default.
- W1966501464 date "2000-01-01" @default.
- W1966501464 modified "2023-09-30" @default.
- W1966501464 title "Cardiac enhancer activity of the homeobox genetinman depends on CREB consensus binding sites inDrosophila" @default.
- W1966501464 cites W1537657975 @default.
- W1966501464 cites W1609632876 @default.
- W1966501464 cites W1900422662 @default.
- W1966501464 cites W1920180263 @default.
- W1966501464 cites W1971443128 @default.
- W1966501464 cites W1973738440 @default.
- W1966501464 cites W1976551887 @default.
- W1966501464 cites W1977746306 @default.
- W1966501464 cites W1980216439 @default.
- W1966501464 cites W1980955976 @default.
- W1966501464 cites W1990158689 @default.
- W1966501464 cites W1998642343 @default.
- W1966501464 cites W2003369513 @default.
- W1966501464 cites W2004537703 @default.
- W1966501464 cites W2012463306 @default.
- W1966501464 cites W2015840464 @default.
- W1966501464 cites W2017198154 @default.
- W1966501464 cites W2020708064 @default.
- W1966501464 cites W2040686597 @default.
- W1966501464 cites W2043217772 @default.
- W1966501464 cites W2049073959 @default.
- W1966501464 cites W2050867644 @default.
- W1966501464 cites W2057845770 @default.
- W1966501464 cites W2058527255 @default.
- W1966501464 cites W2059490316 @default.
- W1966501464 cites W2066092773 @default.
- W1966501464 cites W2069909471 @default.
- W1966501464 cites W2073500834 @default.
- W1966501464 cites W2075579427 @default.
- W1966501464 cites W2076600697 @default.
- W1966501464 cites W2077666738 @default.
- W1966501464 cites W2078422108 @default.
- W1966501464 cites W2087554888 @default.
- W1966501464 cites W2091441330 @default.
- W1966501464 cites W2095683716 @default.
- W1966501464 cites W2096751146 @default.
- W1966501464 cites W2098983125 @default.
- W1966501464 cites W2100070586 @default.
- W1966501464 cites W2101159637 @default.
- W1966501464 cites W2103591458 @default.
- W1966501464 cites W2106000284 @default.
- W1966501464 cites W2109851339 @default.
- W1966501464 cites W2110898138 @default.
- W1966501464 cites W2111525541 @default.
- W1966501464 cites W2115798328 @default.
- W1966501464 cites W2122261320 @default.
- W1966501464 cites W2125655548 @default.
- W1966501464 cites W2126774045 @default.
- W1966501464 cites W2129082959 @default.
- W1966501464 cites W2138283132 @default.
- W1966501464 cites W2152207415 @default.
- W1966501464 cites W2152870216 @default.
- W1966501464 cites W2164315637 @default.
- W1966501464 cites W2336444604 @default.
- W1966501464 cites W2399508784 @default.
- W1966501464 cites W2416254565 @default.
- W1966501464 cites W48985497 @default.
- W1966501464 cites W85256239 @default.
- W1966501464 doi "https://doi.org/10.1002/(sici)1526-968x(200001)26:1<55::aid-gene8>3.0.co;2-a" @default.
- W1966501464 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10660673" @default.
- W1966501464 hasPublicationYear "2000" @default.
- W1966501464 type Work @default.
- W1966501464 sameAs 1966501464 @default.
- W1966501464 citedByCount "41" @default.
- W1966501464 countsByYear W19665014642012 @default.
- W1966501464 countsByYear W19665014642013 @default.
- W1966501464 countsByYear W19665014642014 @default.
- W1966501464 countsByYear W19665014642015 @default.
- W1966501464 countsByYear W19665014642016 @default.
- W1966501464 countsByYear W19665014642017 @default.
- W1966501464 countsByYear W19665014642020 @default.
- W1966501464 crossrefType "journal-article" @default.
- W1966501464 hasAuthorship W1966501464A5038705827 @default.
- W1966501464 hasAuthorship W1966501464A5039497404 @default.
- W1966501464 hasAuthorship W1966501464A5040882990 @default.
- W1966501464 hasAuthorship W1966501464A5049253881 @default.
- W1966501464 hasAuthorship W1966501464A5052631122 @default.
- W1966501464 hasAuthorship W1966501464A5070873780 @default.
- W1966501464 hasAuthorship W1966501464A5087552055 @default.
- W1966501464 hasBestOaLocation W19665014642 @default.
- W1966501464 hasConcept C104317684 @default.
- W1966501464 hasConcept C111936080 @default.
- W1966501464 hasConcept C121587040 @default.
- W1966501464 hasConcept C145103041 @default.
- W1966501464 hasConcept C2776735322 @default.
- W1966501464 hasConcept C2780915607 @default.