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- W1966521801 abstract "The effects of beta-endorphin(beta-End), an endogenous opioid, were tested in vitro on shape changes in polymorphonuclear leukocytes (PMNs). Cell shape changes indicate alterations of the functional status of the cells. Within 2 min, beta-End but not the opioid alkaloid levorphanol or the antagonist, diprenorphine, induced a cell spreading. Subsequently, beta-End and levorphanol (10(-8) M), but not the dextrorotatory isomer, stimulated an elongation of the cells. Both effects of beta-End could be antagonized by diprenorphine in an equimolar concentration. Thus, the effects were stereo-specific and antagonizable. In this test system, the morphological changes evoked by beta-End were equal to the effects of FMLP, a chemotactic substance, used as a reference. Our findings indicate that endogenous opioids might play a role in modulating the initial phase of the PMNs' offensive behaviour, presumably cell adherence and motility." @default.
- W1966521801 created "2016-06-24" @default.
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- W1966521801 date "1985-07-01" @default.
- W1966521801 modified "2023-09-23" @default.
- W1966521801 title "Cell shape of polymorphonuclear leukocytes is influenced by opioids" @default.
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- W1966521801 doi "https://doi.org/10.1016/s0171-2985(85)80007-3" @default.
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