Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966522699> ?p ?o ?g. }
- W1966522699 endingPage "1007" @default.
- W1966522699 startingPage "996" @default.
- W1966522699 abstract "Smoking is responsible for over 400,000 premature deaths in the United States every year, making it the leading cause of preventable death. In addition, smoking-related illness leads to billions of dollars in healthcare expenditures and lost productivity annually. The public is increasingly aware that successfully abstaining from smoking at any age can add years to one's life and reduce many of the harmful effects of smoking. Although the majority of smokers desire to quit, only a small fraction of attempts to quit are actually successful. The symptoms associated with nicotine withdrawal are a primary deterrent to cessation and they need to be quelled to avoid early relapse. This review will focus on the neuroadaptations caused by chronic nicotine exposure and discuss how those changes lead to a withdrawal syndrome upon smoking cessation. Besides examining how nicotine usurps the endogenous reward system, we will discuss how the habenula is part of a circuit that plays a critical role in the aversive effects of high nicotine doses and nicotine withdrawal. We will also provide an updated summary of the role of various nicotinic receptor subtypes in the mechanisms of withdrawal. This growing knowledge provides mechanistic insights into current and future smoking cessation therapies." @default.
- W1966522699 created "2016-06-24" @default.
- W1966522699 creator A5032317344 @default.
- W1966522699 creator A5089699394 @default.
- W1966522699 date "2011-10-01" @default.
- W1966522699 modified "2023-10-16" @default.
- W1966522699 title "Mechanistic insights into nicotine withdrawal" @default.
- W1966522699 cites W1484127898 @default.
- W1966522699 cites W1495806335 @default.
- W1966522699 cites W1512099320 @default.
- W1966522699 cites W1514652138 @default.
- W1966522699 cites W1516172865 @default.
- W1966522699 cites W1528644499 @default.
- W1966522699 cites W1542275754 @default.
- W1966522699 cites W1597278618 @default.
- W1966522699 cites W1637250296 @default.
- W1966522699 cites W1791887780 @default.
- W1966522699 cites W1799536240 @default.
- W1966522699 cites W180320970 @default.
- W1966522699 cites W1835789943 @default.
- W1966522699 cites W1965573444 @default.
- W1966522699 cites W1966980993 @default.
- W1966522699 cites W1967616722 @default.
- W1966522699 cites W1968189433 @default.
- W1966522699 cites W1970886109 @default.
- W1966522699 cites W1971628139 @default.
- W1966522699 cites W1971669832 @default.
- W1966522699 cites W1972302331 @default.
- W1966522699 cites W1972797504 @default.
- W1966522699 cites W1973740048 @default.
- W1966522699 cites W1974129689 @default.
- W1966522699 cites W1974958755 @default.
- W1966522699 cites W1975983467 @default.
- W1966522699 cites W1976972165 @default.
- W1966522699 cites W1977500396 @default.
- W1966522699 cites W1978262730 @default.
- W1966522699 cites W1978702556 @default.
- W1966522699 cites W1980782104 @default.
- W1966522699 cites W1981201955 @default.
- W1966522699 cites W1982972507 @default.
- W1966522699 cites W1983138582 @default.
- W1966522699 cites W1983587045 @default.
- W1966522699 cites W1984346427 @default.
- W1966522699 cites W1985313555 @default.
- W1966522699 cites W1985779068 @default.
- W1966522699 cites W1987559996 @default.
- W1966522699 cites W1988072680 @default.
- W1966522699 cites W1989152115 @default.
- W1966522699 cites W1989416066 @default.
- W1966522699 cites W1989900278 @default.
- W1966522699 cites W1991666427 @default.
- W1966522699 cites W1992440726 @default.
- W1966522699 cites W1992654377 @default.
- W1966522699 cites W1993417422 @default.
- W1966522699 cites W1994725667 @default.
- W1966522699 cites W1995757367 @default.
- W1966522699 cites W1996088460 @default.
- W1966522699 cites W1996108093 @default.
- W1966522699 cites W1996499810 @default.
- W1966522699 cites W1996662707 @default.
- W1966522699 cites W1997065612 @default.
- W1966522699 cites W1998033984 @default.
- W1966522699 cites W1999157638 @default.
- W1966522699 cites W2002531463 @default.
- W1966522699 cites W2005020429 @default.
- W1966522699 cites W2006521913 @default.
- W1966522699 cites W2006670955 @default.
- W1966522699 cites W2007467910 @default.
- W1966522699 cites W2010147037 @default.
- W1966522699 cites W2010171011 @default.
- W1966522699 cites W2010282456 @default.
- W1966522699 cites W2010526028 @default.
- W1966522699 cites W2011582085 @default.
- W1966522699 cites W2011914109 @default.
- W1966522699 cites W2012738237 @default.
- W1966522699 cites W2014155249 @default.
- W1966522699 cites W2014239075 @default.
- W1966522699 cites W2015027944 @default.
- W1966522699 cites W2016085322 @default.
- W1966522699 cites W2017295068 @default.
- W1966522699 cites W2017425600 @default.
- W1966522699 cites W2017696247 @default.
- W1966522699 cites W2019325823 @default.
- W1966522699 cites W2020567468 @default.
- W1966522699 cites W2022939260 @default.
- W1966522699 cites W2023242481 @default.
- W1966522699 cites W2023379737 @default.
- W1966522699 cites W2023597280 @default.
- W1966522699 cites W2024316065 @default.
- W1966522699 cites W2024690874 @default.
- W1966522699 cites W2025022649 @default.
- W1966522699 cites W2025491101 @default.
- W1966522699 cites W2025498694 @default.
- W1966522699 cites W2025788148 @default.
- W1966522699 cites W2026626196 @default.
- W1966522699 cites W2027624603 @default.
- W1966522699 cites W2028440880 @default.
- W1966522699 cites W2028725530 @default.