Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966524674> ?p ?o ?g. }
- W1966524674 endingPage "864" @default.
- W1966524674 startingPage "859" @default.
- W1966524674 abstract "Objectives: Heart-type fatty acid binding protein (hFABP) is an intracellular molecule engaged in the transport of fatty acids through myocardial cytoplasm and has been used as a rapid marker of myocardial infarction. However, its value in the evaluation of perioperative myocardial injury has not yet been assessed. Methods: 32 consecutive patients undergoing coronary artery bypass grafting were included in a prospective, randomized study using standardized operative procedures and myocardial protection. Three patients with perioperative myocardial infarction were added. Serial blood samples were taken preoperatively, before ischemia, 5 and 60 min after declamping, 1 and 6 h postoperatively and on postoperative days 1, 2 and 10 and were tested for hFABP, creatin kinase isoenzyme MB (CKMB) and troponin I (TnI). Results: Hospital mortality was zero. The kinetics of the biochemical parameters revealed a typical pattern for each marker. In routine patients, hFABP levels peaked as early as 1 h after declamping, whereas CKMB and TnI peaked only 1 h after arrival in the intensive care unit. Patients with perioperative infarction displayed peak levels some hours later in all marker proteins. Peak serum levels of hFABP correlated significantly with peak levels of CKMB (r=0.436, P=0.011) and TnI (r=0.548, P=0.001), indicating the degree of myocardial damage. Conclusions: hFABP is a rapid marker of perioperative myocardial damage and peaks earlier than CKMB or TnI. The kinetics of marker proteins in serial samples immediately after reperfusion is more suitable for the detection of perioperative myocardial infarction than a fixed cut-off level." @default.
- W1966524674 created "2016-06-24" @default.
- W1966524674 creator A5016308493 @default.
- W1966524674 creator A5023960606 @default.
- W1966524674 creator A5035104810 @default.
- W1966524674 creator A5041491020 @default.
- W1966524674 creator A5080322732 @default.
- W1966524674 creator A5081822906 @default.
- W1966524674 date "2001-06-01" @default.
- W1966524674 modified "2023-10-11" @default.
- W1966524674 title "Heart-type fatty acid binding protein (hFABP) in the diagnosis of myocardial damage in coronary artery bypass grafting" @default.
- W1966524674 cites W13423698 @default.
- W1966524674 cites W1971467939 @default.
- W1966524674 cites W1978220640 @default.
- W1966524674 cites W1980730366 @default.
- W1966524674 cites W1981698321 @default.
- W1966524674 cites W1985840748 @default.
- W1966524674 cites W1988768888 @default.
- W1966524674 cites W2013431758 @default.
- W1966524674 cites W2023023486 @default.
- W1966524674 cites W2033798801 @default.
- W1966524674 cites W2036010456 @default.
- W1966524674 cites W2044105388 @default.
- W1966524674 cites W2046101623 @default.
- W1966524674 cites W2055104314 @default.
- W1966524674 cites W2058888796 @default.
- W1966524674 cites W2062336535 @default.
- W1966524674 cites W2066047809 @default.
- W1966524674 cites W2077752217 @default.
- W1966524674 cites W2078113728 @default.
- W1966524674 cites W2116280371 @default.
- W1966524674 cites W2139997555 @default.
- W1966524674 cites W2313351478 @default.
- W1966524674 cites W2336020677 @default.
- W1966524674 doi "https://doi.org/10.1016/s1010-7940(01)00709-6" @default.
- W1966524674 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11404143" @default.
- W1966524674 hasPublicationYear "2001" @default.
- W1966524674 type Work @default.
- W1966524674 sameAs 1966524674 @default.
- W1966524674 citedByCount "39" @default.
- W1966524674 countsByYear W19665246742013 @default.
- W1966524674 countsByYear W19665246742014 @default.
- W1966524674 countsByYear W19665246742015 @default.
- W1966524674 countsByYear W19665246742016 @default.
- W1966524674 countsByYear W19665246742017 @default.
- W1966524674 countsByYear W19665246742020 @default.
- W1966524674 countsByYear W19665246742021 @default.
- W1966524674 crossrefType "journal-article" @default.
- W1966524674 hasAuthorship W1966524674A5016308493 @default.
- W1966524674 hasAuthorship W1966524674A5023960606 @default.
- W1966524674 hasAuthorship W1966524674A5035104810 @default.
- W1966524674 hasAuthorship W1966524674A5041491020 @default.
- W1966524674 hasAuthorship W1966524674A5080322732 @default.
- W1966524674 hasAuthorship W1966524674A5081822906 @default.
- W1966524674 hasBestOaLocation W19665246741 @default.
- W1966524674 hasConcept C104317684 @default.
- W1966524674 hasConcept C115725540 @default.
- W1966524674 hasConcept C126322002 @default.
- W1966524674 hasConcept C141071460 @default.
- W1966524674 hasConcept C144469398 @default.
- W1966524674 hasConcept C164705383 @default.
- W1966524674 hasConcept C185592680 @default.
- W1966524674 hasConcept C2776820930 @default.
- W1966524674 hasConcept C2776834966 @default.
- W1966524674 hasConcept C2778532138 @default.
- W1966524674 hasConcept C2779280647 @default.
- W1966524674 hasConcept C31174226 @default.
- W1966524674 hasConcept C36036425 @default.
- W1966524674 hasConcept C500558357 @default.
- W1966524674 hasConcept C55493867 @default.
- W1966524674 hasConcept C71924100 @default.
- W1966524674 hasConceptScore W1966524674C104317684 @default.
- W1966524674 hasConceptScore W1966524674C115725540 @default.
- W1966524674 hasConceptScore W1966524674C126322002 @default.
- W1966524674 hasConceptScore W1966524674C141071460 @default.
- W1966524674 hasConceptScore W1966524674C144469398 @default.
- W1966524674 hasConceptScore W1966524674C164705383 @default.
- W1966524674 hasConceptScore W1966524674C185592680 @default.
- W1966524674 hasConceptScore W1966524674C2776820930 @default.
- W1966524674 hasConceptScore W1966524674C2776834966 @default.
- W1966524674 hasConceptScore W1966524674C2778532138 @default.
- W1966524674 hasConceptScore W1966524674C2779280647 @default.
- W1966524674 hasConceptScore W1966524674C31174226 @default.
- W1966524674 hasConceptScore W1966524674C36036425 @default.
- W1966524674 hasConceptScore W1966524674C500558357 @default.
- W1966524674 hasConceptScore W1966524674C55493867 @default.
- W1966524674 hasConceptScore W1966524674C71924100 @default.
- W1966524674 hasIssue "6" @default.
- W1966524674 hasLocation W19665246741 @default.
- W1966524674 hasLocation W19665246742 @default.
- W1966524674 hasOpenAccess W1966524674 @default.
- W1966524674 hasPrimaryLocation W19665246741 @default.
- W1966524674 hasRelatedWork W1996758490 @default.
- W1966524674 hasRelatedWork W2351660670 @default.
- W1966524674 hasRelatedWork W2367789194 @default.
- W1966524674 hasRelatedWork W2371440261 @default.
- W1966524674 hasRelatedWork W2374879291 @default.
- W1966524674 hasRelatedWork W2383249560 @default.