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- W1966528069 abstract "The regulatory (R) region of the cystic fibrosis transmembrane conductance regulator (CFTR) is intrinsically disordered and must be phosphorylated at multiple sites for full CFTR channel activity, with no one specific phosphorylation site required. In addition, nucleotide binding and hydrolysis at the nucleotide-binding domains (NBDs) of CFTR are required for channel gating. We report NMR studies in the absence and presence of NBD1 that provide structural details for the isolated R region and its interaction with NBD1 at residue-level resolution. Several sites in the R region with measured fractional helical propensity mediate interactions with NBD1. Phosphorylation reduces the helicity of many R-region sites and reduces their NBD1 interactions. This evidence for a dynamic complex with NBD1 that transiently engages different sites of the R region suggests a structural explanation for the dependence of CFTR activity on multiple PKA phosphorylation sites." @default.
- W1966528069 created "2016-06-24" @default.
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- W1966528069 date "2007-07-29" @default.
- W1966528069 modified "2023-10-18" @default.
- W1966528069 title "CFTR regulatory region interacts with NBD1 predominantly via multiple transient helices" @default.
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- W1966528069 doi "https://doi.org/10.1038/nsmb1278" @default.
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