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- W1966530431 abstract "Abstract Neurophysiological experiments were performed in chronically implanted cats continuously recorded. In normal cats small doses of 5-HTP (5 mg/kg) had no significant effect, whereas large doses (50 mg/kg) induced a state of EEG synchronization with suppression of paradoxical sleep for 8 h. The insomnia that followed the injection of 400 mg ofp-chlorophenylalanine/kg reached its maximum after 40 h. Injection of 5 mg of dl -5-HTP/kg at the time of maximal insomnia restored both slow-wave sleep and paradoxical sleep to normal levels during 5–6 h. Injection of 50 mg of 5-HTP/kg restored normal levels of both states of sleep for 12 h. The insomnia that followed surgical destruction of the raphe´system was not reversible by small or large doses of 5-HTP. Biochemical investigations were performedin vitro, on the brains of cats killed during the time of maximal pharmacologically induced insomnia or 8 days after the destruction of the raphe´system. The synthesis of [3H]5-HT from [3H]Trp was impaired in both categories, whereas the synthesis of [3H]5-HT from [3H]5-HTP was normal. It is concluded that in normal conditions, exogenous 5-HTP is not a physiological precursor of 5-HT at the central 5-HT terminal. However, in PCPA-treated cats, exogenous 5-HTP, in small doses, could represent a physiological precursor of 5-HT. The relationship between 5-HT-containing neurons and sleep are discussed." @default.
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- W1966530431 date "1971-06-01" @default.
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- W1966530431 title "The central metabolism of serotonin in the cat during insomnia. A neurophysiological and biochemical study after administration ofP-chlorophenylalanine or destruction of the raphe´system" @default.
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- W1966530431 doi "https://doi.org/10.1016/0006-8993(71)90028-x" @default.
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