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• W1966533134 abstract "When the Mn 2+ and Ca 2+ ions normally present in concanavalin A are removed, the protein becomes incapable of binding saccharides. To explore the structural differences between the native and demetallized forms and their effects on the saccharide-binding properties of the protein, we have refined and compared the crystal structures of both forms. Refinement, carried out by automated difference Fourier methods, has revealed a number of differences between the two structures as well as minor differences between the two crystallographically independent monomers in the demetallized structure. Significant differences between the holo- and apoproteins are confined to the region where the metals are bound. These differences include a reorganization and disordering of the loop, consisting of residues 7-25, that contains all of the direct metal ligands of the protein. In some molecules, the side chain of arginine-228 appears to move into the metal-binding region, possibly compensating in part for the absence of the metal's positive charge. The cis peptide observed in the native protein at alanine-207 is apparently not present in the demetallized protein. The conformational differences affect many of the residues currently thought to be involved in the specific binding of saccharides." @default.
• W1966533134 created "2016-06-24" @default.
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• W1966533134 date "1978-05-01" @default.
• W1966533134 modified "2023-09-27" @default.
• W1966533134 title "Changes in the three-dimensional structure of concanavalin A upon demetallization" @default.
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• W1966533134 doi "https://doi.org/10.1073/pnas.75.5.2286" @default.
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