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- W1966538236 abstract "We have previously described the activation of the classical, alternative, and terminal complement cascade pathways after acute contusion spinal cord injury using the New York University (NYU) weight-drop impactor. In the present study, we examined the induction of protein regulators of the complement cascade, factor H (FH), and clusterin, in the same experimental paradigm. The spinal cord of laminectomized adult rats was subjected to mild or severe injury using impactor weight-drop heights of 12.5 and 50 mm, respectively. The spinal cords of control and injured animals were evaluated at 1, 7, and 42 days after injury. Immunocytochemistry revealed a robust increase in the numbers and intensity of staining of FH, and clusterin-positive cells in the injured cord at all three time points, with the highest increases observed at 1 and 42 days after injury. FH and clusterin-positive cells were observed among neurons as well as oligodendrocytes. The increased expression was detected both rostrally and caudally from the injury site, in the latter case at distances up to 20 mm. The precise biological significance of injury-induced upregulation of these proteins remains to be determined. However, FH and clusterin are potent regulators of complement activity targeting upstream (FH) and downstream (clusterin) molecules of the pro-inflammatory cascade, which could be of vital importance in preventing a runaway inflammatory reaction in the injured spinal cord." @default.
- W1966538236 created "2016-06-24" @default.
- W1966538236 creator A5018750805 @default.
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- W1966538236 date "2005-03-01" @default.
- W1966538236 modified "2023-10-05" @default.
- W1966538236 title "Upregulation of Complement Inhibitors in Association with Vulnerable Cells following Contusion-Induced Spinal Cord Injury" @default.
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- W1966538236 doi "https://doi.org/10.1089/neu.2005.22.382" @default.
- W1966538236 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15785233" @default.
- W1966538236 hasPublicationYear "2005" @default.
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