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• W1966543040 abstract "The heart is a multiphysics and multiscale system that has driven the development of the most sophisticated mathematical models at the frontiers of computational physiology and medicine. This review focuses on electromechanical (EM) models of the heart from the molecular level of myofilaments to anatomical models of the organ. Because of the coupling in terms of function and emergent behaviors at each level of biological hierarchy, separation of behaviors at a given scale is difficult. Here, a separation is drawn at the cell level so that the first half addresses subcellular/single-cell models and the second half addresses organ models. At the subcellular level, myofilament models represent actin-myosin interaction and Ca-based activation. The discussion of specific models emphasizes the roles of cooperative mechanisms and sarcomere length dependence of contraction force, considered to be the cellular basis of the Frank-Starling law. A model of electrophysiology and Ca handling can be coupled to a myofilament model to produce an EM cell model, and representative examples are summarized to provide an overview of the progression of the field. The second half of the review covers organ-level models that require solution of the electrical component as a reaction-diffusion system and the mechanical component, in which active tension generated by the myocytes produces deformation of the organ as described by the equations of continuum mechanics. As outlined in the review, different organ-level models have chosen to use different ionic and myofilament models depending on the specific application; this choice has been largely dictated by compromises between model complexity and computational tractability. The review also addresses application areas of EM models such as cardiac resynchronization therapy and the role of mechano-electric coupling in arrhythmias and defibrillation." @default.
• W1966543040 created "2016-06-24" @default.
• W1966543040 creator A5031395616 @default.
• W1966543040 creator A5070924694 @default.
• W1966543040 date "2011-01-01" @default.
• W1966543040 modified "2023-10-18" @default.
• W1966543040 title "Cardiac Electromechanical Models: From Cell to Organ" @default.
• W1966543040 cites W1480084192 @default.
• W1966543040 cites W1490442168 @default.
• W1966543040 cites W1499122117 @default.
• W1966543040 cites W1509673833 @default.
• W1966543040 cites W1513704891 @default.
• W1966543040 cites W1550726172 @default.
• W1966543040 cites W1608432638 @default.
• W1966543040 cites W184796931 @default.
• W1966543040 cites W1901823973 @default.
• W1966543040 cites W1951774030 @default.
• W1966543040 cites W195661890 @default.
• W1966543040 cites W1964430604 @default.
• W1966543040 cites W1965940419 @default.
• W1966543040 cites W1967620858 @default.
• W1966543040 cites W1970195157 @default.
• W1966543040 cites W1971720765 @default.
• W1966543040 cites W1973072461 @default.
• W1966543040 cites W1974308265 @default.
• W1966543040 cites W1976232772 @default.
• W1966543040 cites W1977098804 @default.
• W1966543040 cites W1977643020 @default.
• W1966543040 cites W1978435915 @default.
• W1966543040 cites W1979558432 @default.
• W1966543040 cites W1980161127 @default.
• W1966543040 cites W1980685237 @default.
• W1966543040 cites W1982140992 @default.
• W1966543040 cites W1986808125 @default.
• W1966543040 cites W1988266788 @default.
• W1966543040 cites W1989255509 @default.
• W1966543040 cites W1992154841 @default.
• W1966543040 cites W1992292489 @default.
• W1966543040 cites W1993958122 @default.
• W1966543040 cites W2001616350 @default.
• W1966543040 cites W2002606794 @default.
• W1966543040 cites W2004503297 @default.
• W1966543040 cites W2005865511 @default.
• W1966543040 cites W2007519522 @default.
• W1966543040 cites W2009988419 @default.
• W1966543040 cites W2014752916 @default.
• W1966543040 cites W2015662113 @default.
• W1966543040 cites W2017138224 @default.
• W1966543040 cites W2019201408 @default.
• W1966543040 cites W2021313599 @default.
• W1966543040 cites W2021674119 @default.
• W1966543040 cites W2026287524 @default.
• W1966543040 cites W2030011403 @default.
• W1966543040 cites W2031294645 @default.
• W1966543040 cites W2033270900 @default.
• W1966543040 cites W2037462241 @default.
• W1966543040 cites W2037576214 @default.
• W1966543040 cites W2038237757 @default.
• W1966543040 cites W2038559261 @default.
• W1966543040 cites W2039645445 @default.
• W1966543040 cites W2041237692 @default.
• W1966543040 cites W2044360039 @default.
• W1966543040 cites W2053175645 @default.
• W1966543040 cites W2054660467 @default.
• W1966543040 cites W2061457365 @default.
• W1966543040 cites W2062616395 @default.
• W1966543040 cites W2065278823 @default.
• W1966543040 cites W2067789739 @default.
• W1966543040 cites W2072334737 @default.
• W1966543040 cites W2073367883 @default.
• W1966543040 cites W2074355842 @default.
• W1966543040 cites W2077653370 @default.
• W1966543040 cites W2077999459 @default.
• W1966543040 cites W2078148739 @default.
• W1966543040 cites W2079801399 @default.
• W1966543040 cites W2082594221 @default.
• W1966543040 cites W2083132667 @default.
• W1966543040 cites W2084421529 @default.
• W1966543040 cites W2085217985 @default.
• W1966543040 cites W2088559019 @default.
• W1966543040 cites W2088653672 @default.
• W1966543040 cites W2089124023 @default.
• W1966543040 cites W2089158318 @default.
• W1966543040 cites W2093186299 @default.
• W1966543040 cites W2093572356 @default.
• W1966543040 cites W2097754164 @default.
• W1966543040 cites W2097949661 @default.
• W1966543040 cites W2099767007 @default.
• W1966543040 cites W2104449065 @default.
• W1966543040 cites W2104701510 @default.
• W1966543040 cites W2107954466 @default.
• W1966543040 cites W2113326538 @default.
• W1966543040 cites W2116143035 @default.
• W1966543040 cites W2119541189 @default.
• W1966543040 cites W2119938494 @default.
• W1966543040 cites W2120327065 @default.
• W1966543040 cites W2120530986 @default.
• W1966543040 cites W2121725665 @default.
• W1966543040 cites W2124895600 @default.
• W1966543040 cites W2130858105 @default.

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