Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966553359> ?p ?o ?g. }
- W1966553359 endingPage "665" @default.
- W1966553359 startingPage "659" @default.
- W1966553359 abstract "The availability of a clone containing two linked immunoglobulin heavy chain variable region genes located 15.8 kb apart has allowed us to study the functional capabilities of the immunoglobulin heavy chain transcriptional enhancer element in its normal chromosomal context. In plasmacytoma J606 the 3' VH gene is joined to D and J gene segments, located within 1.7 kb of the heavy chain enhancer, and expressed; the 5' VH gene is 17.5 kb from the enhancer in J606 DNA. Run-on transcription in isolated nuclei demonstrated specific transcription of the 5' VH gene in J606 that was 60% that of the expressed 3' VH gene. No other enhancer elements are detectable closer to the 5' VH gene than the known heavy chain enhancer. Thus, the heavy chain enhancer appears to be capable of activating transcription of a VH promoter located 17.5 kb away and of activating two tandem VH promoters." @default.
- W1966553359 created "2016-06-24" @default.
- W1966553359 creator A5005637454 @default.
- W1966553359 creator A5058268034 @default.
- W1966553359 date "1985-12-01" @default.
- W1966553359 modified "2023-09-26" @default.
- W1966553359 title "The endogenous immunoglobulin heavy chain enhancer can activate tandem VH promoters separated by a large distance" @default.
- W1966553359 cites W1567006599 @default.
- W1966553359 cites W1579796122 @default.
- W1966553359 cites W1598530978 @default.
- W1966553359 cites W1849337921 @default.
- W1966553359 cites W1964692033 @default.
- W1966553359 cites W1966254031 @default.
- W1966553359 cites W1971285426 @default.
- W1966553359 cites W1971420993 @default.
- W1966553359 cites W1974582630 @default.
- W1966553359 cites W1994264419 @default.
- W1966553359 cites W1998385486 @default.
- W1966553359 cites W2002397775 @default.
- W1966553359 cites W2006111721 @default.
- W1966553359 cites W2006761445 @default.
- W1966553359 cites W2013545053 @default.
- W1966553359 cites W2019590714 @default.
- W1966553359 cites W2022081023 @default.
- W1966553359 cites W2035731990 @default.
- W1966553359 cites W2037969118 @default.
- W1966553359 cites W2038218774 @default.
- W1966553359 cites W2057893650 @default.
- W1966553359 cites W2061102119 @default.
- W1966553359 cites W2061429557 @default.
- W1966553359 cites W2062408930 @default.
- W1966553359 cites W2067956561 @default.
- W1966553359 cites W2068378281 @default.
- W1966553359 cites W2070855057 @default.
- W1966553359 cites W2072467553 @default.
- W1966553359 cites W2077418781 @default.
- W1966553359 cites W2078436276 @default.
- W1966553359 cites W2079337115 @default.
- W1966553359 cites W2082030057 @default.
- W1966553359 cites W2089219831 @default.
- W1966553359 cites W2089298737 @default.
- W1966553359 cites W2090458585 @default.
- W1966553359 cites W2092216600 @default.
- W1966553359 cites W2092299362 @default.
- W1966553359 cites W2093988305 @default.
- W1966553359 cites W2109448523 @default.
- W1966553359 cites W2119859213 @default.
- W1966553359 cites W2144206181 @default.
- W1966553359 cites W2145059527 @default.
- W1966553359 doi "https://doi.org/10.1016/0092-8674(85)90238-7" @default.
- W1966553359 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2866846" @default.
- W1966553359 hasPublicationYear "1985" @default.
- W1966553359 type Work @default.
- W1966553359 sameAs 1966553359 @default.
- W1966553359 citedByCount "82" @default.
- W1966553359 crossrefType "journal-article" @default.
- W1966553359 hasAuthorship W1966553359A5005637454 @default.
- W1966553359 hasAuthorship W1966553359A5058268034 @default.
- W1966553359 hasConcept C101762097 @default.
- W1966553359 hasConcept C104317684 @default.
- W1966553359 hasConcept C111936080 @default.
- W1966553359 hasConcept C138885662 @default.
- W1966553359 hasConcept C150194340 @default.
- W1966553359 hasConcept C153911025 @default.
- W1966553359 hasConcept C159654299 @default.
- W1966553359 hasConcept C179926584 @default.
- W1966553359 hasConcept C21784809 @default.
- W1966553359 hasConcept C3020196193 @default.
- W1966553359 hasConcept C36394416 @default.
- W1966553359 hasConcept C41895202 @default.
- W1966553359 hasConcept C54355233 @default.
- W1966553359 hasConcept C86339819 @default.
- W1966553359 hasConcept C86803240 @default.
- W1966553359 hasConcept C96007430 @default.
- W1966553359 hasConceptScore W1966553359C101762097 @default.
- W1966553359 hasConceptScore W1966553359C104317684 @default.
- W1966553359 hasConceptScore W1966553359C111936080 @default.
- W1966553359 hasConceptScore W1966553359C138885662 @default.
- W1966553359 hasConceptScore W1966553359C150194340 @default.
- W1966553359 hasConceptScore W1966553359C153911025 @default.
- W1966553359 hasConceptScore W1966553359C159654299 @default.
- W1966553359 hasConceptScore W1966553359C179926584 @default.
- W1966553359 hasConceptScore W1966553359C21784809 @default.
- W1966553359 hasConceptScore W1966553359C3020196193 @default.
- W1966553359 hasConceptScore W1966553359C36394416 @default.
- W1966553359 hasConceptScore W1966553359C41895202 @default.
- W1966553359 hasConceptScore W1966553359C54355233 @default.
- W1966553359 hasConceptScore W1966553359C86339819 @default.
- W1966553359 hasConceptScore W1966553359C86803240 @default.
- W1966553359 hasConceptScore W1966553359C96007430 @default.
- W1966553359 hasIssue "3" @default.
- W1966553359 hasLocation W19665533591 @default.
- W1966553359 hasLocation W19665533592 @default.
- W1966553359 hasOpenAccess W1966553359 @default.
- W1966553359 hasPrimaryLocation W19665533591 @default.
- W1966553359 hasRelatedWork W1966553359 @default.
- W1966553359 hasRelatedWork W1976447027 @default.
- W1966553359 hasRelatedWork W2030696171 @default.