FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966554108> ?p ?o ?g. }

• W1966554108 endingPage "729" @default.
• W1966554108 startingPage "715" @default.
• W1966554108 abstract "Respiratory distress that leads to death is seen in patients with Lassa fever. The development of this respiratory problem was studied using a Pichinde virus model (104 plaque forming units, IP, survival time 20 ± 1 days) in strain 13 guinea pigs (n = 35, 229–353 g) of this lethal human contagious infectious disease. Extravascular lung water to bloodless dry lung weight (EVLW/BDLW) ratio showed a modest yet significant increase in animals 13 and 18–21 days postinoculation (PI). In contrast, residual lung blood and lung radioactive 125I-labeled human serum albumin activity index were elevated only in the 18- to 21-day group. These data are consistent with the progressive severity of perivascular edema, lymphocytic pneumonitis, and some alveolar protein between days 13 and 18–21 PI. Lymphocytic pneumonitis appeared to be distributed near most airways and was proportional to the degree of Pichinde virus antigen staining of alveolar macrophages, large mononuclear cells within the pulmonary vascular and extravascular spaces, and alveolar-capillary membranes. These findings suggest that lymphocyte recruitment to the lung reflects the Pichinde virus-induced cell-mediated immune response. Obstructed small bronchi with some lumenal cell debris and hypertrophied epithelial cells were found associated with the areas of marked pneumonitis. The severe hypoxemia and modest anaerobic metabolism in association with marked tachypnea and normocapnia are consistent with small airway obstruction and wasted ventilation, since no change in arterial blood pressure, heart rate, hematocrit, hemoglobin, or blood volume was noted. These data suggest that Pichinde virus-induced respiratory failure was due to obstruction of the small airways with wasted ventilation in association with lymphocytic pneumonitis." @default.
• W1966554108 created "2016-06-24" @default.
• W1966554108 creator A5018800087 @default.
• W1966554108 creator A5028721437 @default.
• W1966554108 creator A5036374087 @default.
• W1966554108 creator A5071989328 @default.
• W1966554108 creator A5078734579 @default.
• W1966554108 date "1993-01-01" @default.
• W1966554108 modified "2023-10-18" @default.
• W1966554108 title "PichindeVirus-Induced Respiratory Failure Due to Obstruction of the Small Airways: Structure and Function" @default.
• W1966554108 cites W1509033271 @default.
• W1966554108 cites W1939567899 @default.
• W1966554108 cites W1975490891 @default.
• W1966554108 cites W2004556731 @default.
• W1966554108 cites W2005804757 @default.
• W1966554108 cites W2011609161 @default.
• W1966554108 cites W2016013849 @default.
• W1966554108 cites W2058007230 @default.
• W1966554108 cites W2064469571 @default.
• W1966554108 cites W2071881682 @default.
• W1966554108 cites W2084347712 @default.
• W1966554108 cites W2113771074 @default.
• W1966554108 cites W2117594247 @default.
• W1966554108 cites W2128286567 @default.
• W1966554108 cites W2139450100 @default.
• W1966554108 cites W2315668890 @default.
• W1966554108 doi "https://doi.org/10.3109/01902149309064367" @default.
• W1966554108 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8281916" @default.
• W1966554108 hasPublicationYear "1993" @default.
• W1966554108 type Work @default.
• W1966554108 sameAs 1966554108 @default.
• W1966554108 citedByCount "4" @default.
• W1966554108 countsByYear W19665541082012 @default.
• W1966554108 crossrefType "journal-article" @default.
• W1966554108 hasAuthorship W1966554108A5018800087 @default.
• W1966554108 hasAuthorship W1966554108A5028721437 @default.
• W1966554108 hasAuthorship W1966554108A5036374087 @default.
• W1966554108 hasAuthorship W1966554108A5071989328 @default.
• W1966554108 hasAuthorship W1966554108A5078734579 @default.
• W1966554108 hasConcept C126322002 @default.
• W1966554108 hasConcept C142724271 @default.
• W1966554108 hasConcept C164705383 @default.
• W1966554108 hasConcept C203014093 @default.
• W1966554108 hasConcept C2777714996 @default.
• W1966554108 hasConcept C534529494 @default.
• W1966554108 hasConcept C71924100 @default.
• W1966554108 hasConceptScore W1966554108C126322002 @default.
• W1966554108 hasConceptScore W1966554108C142724271 @default.
• W1966554108 hasConceptScore W1966554108C164705383 @default.
• W1966554108 hasConceptScore W1966554108C203014093 @default.
• W1966554108 hasConceptScore W1966554108C2777714996 @default.
• W1966554108 hasConceptScore W1966554108C534529494 @default.
• W1966554108 hasConceptScore W1966554108C71924100 @default.
• W1966554108 hasIssue "6" @default.
• W1966554108 hasLocation W19665541081 @default.
• W1966554108 hasLocation W19665541082 @default.
• W1966554108 hasOpenAccess W1966554108 @default.
• W1966554108 hasPrimaryLocation W19665541081 @default.
• W1966554108 hasRelatedWork W2011347913 @default.
• W1966554108 hasRelatedWork W2049397185 @default.
• W1966554108 hasRelatedWork W2073151595 @default.
• W1966554108 hasRelatedWork W2074833529 @default.
• W1966554108 hasRelatedWork W2125804349 @default.
• W1966554108 hasRelatedWork W2159512267 @default.
• W1966554108 hasRelatedWork W2304633692 @default.
• W1966554108 hasRelatedWork W2355498105 @default.
• W1966554108 hasRelatedWork W2399063111 @default.
• W1966554108 hasRelatedWork W2404684281 @default.
• W1966554108 hasVolume "19" @default.
• W1966554108 isParatext "false" @default.
• W1966554108 isRetracted "false" @default.
• W1966554108 magId "1966554108" @default.
• W1966554108 workType "article" @default.