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- W1966555364 abstract "<h2>Abstract</h2> Changes in protein synthesis were studied in different organs of rabbits after the cessation of vital activity and during reanimation. The effect of artificial post-mortem cooling on protein synthesis was examined to analyse the factors contributing to the restoration of assimilatory processes and the resuscitation of the whole animal. The animals were killed by exsanguination, and reanimated with artificial circulation. Post-mortem cooling was started 10 min after death. Protein synthesis was estimated from the incorporation of labelled amino acids into protein molecules. Protein synthesis ceased in all organs at different times after death, first in spleen and brain, and much later in pancreas tissue. These disturbances of the assimilatory process could be reversed by artificial circulation within 20 min of death. However, the degree of restoration of protein synthesis was not uniform in the different organs; it was slight in spleen and brain, whereas in the heart and pancreas it reached the rate of that of a living organism. Restoration of protein synthesis was associated with the recovery of the whole animal's vital activity. The restoration of protein synthesis and vital activity could be achieved from 10 to 60 min after death by post-mortem cooling. Rapid artificial cooling after the cessation of vital activity resulted in prolonging the period during which the vital activity of the organism was retained." @default.
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- W1966555364 date "1972-07-01" @default.
- W1966555364 modified "2023-10-16" @default.
- W1966555364 title "Changes in protein synthesis after death and reanimation of rabbits" @default.
- W1966555364 doi "https://doi.org/10.1016/0300-9572(72)90016-0" @default.
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