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- W1966557693 abstract "To evaluate the protective effect of epidermal powder immunization (EPI) against equine herpesvirus-1 (EHV-1) infection, we prepared a powder vaccine in which formalin-inactivated virions were embedded in water-soluble, sugar-based particles. A PowderJect device was used to immunize mice with the powder vaccine via their abdominal skin. We found that twice-immunized mice were protected against challenge with the wild-type virus. This protective effect was equivalent to or better than that observed in mice immunized with other types of vaccines, including a gene gun-mediated DNA vaccine containing the glycoprotein D (gD) gene or conventional inactivated virus vaccines introduced via intramuscular or intranasal injections. These findings indicate that the powder vaccine is a promising approach for the immunological control of EHV-1 infection, either alone or as a part of prime-boost vaccination strategies." @default.
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- W1966557693 date "2004-01-01" @default.
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- W1966557693 title "A protective effect of epidermal powder immunization in a mouse model of equine herpesvirus-1 infection" @default.
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- W1966557693 doi "https://doi.org/10.1016/j.virol.2003.09.031" @default.
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