FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966559009> ?p ?o ?g. }

• W1966559009 endingPage "781" @default.
• W1966559009 startingPage "772" @default.
• W1966559009 abstract "The conserved lin-4 microRNA (miRNA) regulates the proper timing of stem cell fate decisions in C. elegans by regulating stemness genes such as lin-14 and lin-28. (1)(-) (3) While lin-4 is upregulated toward the end of the first larval stage and functions as an essential developmental timing switch, little is known about how lin-4 expression is regulated. (4) Here we show that in C. elegans hypodermal seam cells, transcription of lin-4 is positively regulated by lin-4 itself. In these cells, lin-4 activates its own transcription through a conserved lin-4-complementary element (LCE) in its promoter. We further show that lin-4 is required to recruit RNA polymerase II to its own promoter, and that lin-4 overexpression is sufficient for autoactivation. Finally, we show that a protein complex specifically binds the LCE in vitro, and that mutations that abolish this binding also reduce the in vivo expression of a plin-4:GFP reporter. Thus, we describe the first in vivo evidence of RNA activation (RNAa) by an endogenous miRNA, and provide new insights into an elegant autoregulatory mechanism that ensures the proper timing of stem cell fate decisions in development." @default.
• W1966559009 created "2016-06-24" @default.
• W1966559009 creator A5013989133 @default.
• W1966559009 creator A5086404717 @default.
• W1966559009 creator A5087424428 @default.
• W1966559009 date "2014-01-07" @default.
• W1966559009 modified "2023-10-12" @default.
• W1966559009 title "Autoregulation of<i>lin-4</i>microRNA transcription by RNA activation (RNAa) in<i>C. elegans</i>" @default.
• W1966559009 cites W1975437957 @default.
• W1966559009 cites W1992960655 @default.
• W1966559009 cites W1998734533 @default.
• W1966559009 cites W1999605403 @default.
• W1966559009 cites W2011389479 @default.
• W1966559009 cites W2011480379 @default.
• W1966559009 cites W2013793916 @default.
• W1966559009 cites W2021409703 @default.
• W1966559009 cites W2025911047 @default.
• W1966559009 cites W2028141043 @default.
• W1966559009 cites W2032264626 @default.
• W1966559009 cites W2036802778 @default.
• W1966559009 cites W2038720758 @default.
• W1966559009 cites W2048829654 @default.
• W1966559009 cites W2058711543 @default.
• W1966559009 cites W2066204446 @default.
• W1966559009 cites W2067742553 @default.
• W1966559009 cites W2074300285 @default.
• W1966559009 cites W2075123253 @default.
• W1966559009 cites W2080356693 @default.
• W1966559009 cites W2081201102 @default.
• W1966559009 cites W2085516557 @default.
• W1966559009 cites W2100290573 @default.
• W1966559009 cites W2101211308 @default.
• W1966559009 cites W2102545933 @default.
• W1966559009 cites W2102840368 @default.
• W1966559009 cites W2105444747 @default.
• W1966559009 cites W2116362436 @default.
• W1966559009 cites W2119031123 @default.
• W1966559009 cites W2138664009 @default.
• W1966559009 cites W2145084130 @default.
• W1966559009 cites W2158789461 @default.
• W1966559009 cites W2160467221 @default.
• W1966559009 cites W2164802944 @default.
• W1966559009 doi "https://doi.org/10.4161/cc.27679" @default.
• W1966559009 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3979913" @default.
• W1966559009 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24398561" @default.
• W1966559009 hasPublicationYear "2014" @default.
• W1966559009 type Work @default.
• W1966559009 sameAs 1966559009 @default.
• W1966559009 citedByCount "41" @default.
• W1966559009 countsByYear W19665590092014 @default.
• W1966559009 countsByYear W19665590092015 @default.
• W1966559009 countsByYear W19665590092016 @default.
• W1966559009 countsByYear W19665590092017 @default.
• W1966559009 countsByYear W19665590092018 @default.
• W1966559009 countsByYear W19665590092019 @default.
• W1966559009 countsByYear W19665590092020 @default.
• W1966559009 countsByYear W19665590092021 @default.
• W1966559009 countsByYear W19665590092022 @default.
• W1966559009 countsByYear W19665590092023 @default.
• W1966559009 crossrefType "journal-article" @default.
• W1966559009 hasAuthorship W1966559009A5013989133 @default.
• W1966559009 hasAuthorship W1966559009A5086404717 @default.
• W1966559009 hasAuthorship W1966559009A5087424428 @default.
• W1966559009 hasBestOaLocation W19665590091 @default.
• W1966559009 hasConcept C104317684 @default.
• W1966559009 hasConcept C138885662 @default.
• W1966559009 hasConcept C145059251 @default.
• W1966559009 hasConcept C163952510 @default.
• W1966559009 hasConcept C179926584 @default.
• W1966559009 hasConcept C2778944004 @default.
• W1966559009 hasConcept C41895202 @default.
• W1966559009 hasConcept C54355233 @default.
• W1966559009 hasConcept C86339819 @default.
• W1966559009 hasConcept C86803240 @default.
• W1966559009 hasConcept C95444343 @default.
• W1966559009 hasConceptScore W1966559009C104317684 @default.
• W1966559009 hasConceptScore W1966559009C138885662 @default.
• W1966559009 hasConceptScore W1966559009C145059251 @default.
• W1966559009 hasConceptScore W1966559009C163952510 @default.
• W1966559009 hasConceptScore W1966559009C179926584 @default.
• W1966559009 hasConceptScore W1966559009C2778944004 @default.
• W1966559009 hasConceptScore W1966559009C41895202 @default.
• W1966559009 hasConceptScore W1966559009C54355233 @default.
• W1966559009 hasConceptScore W1966559009C86339819 @default.
• W1966559009 hasConceptScore W1966559009C86803240 @default.
• W1966559009 hasConceptScore W1966559009C95444343 @default.
• W1966559009 hasIssue "5" @default.
• W1966559009 hasLocation W19665590091 @default.
• W1966559009 hasLocation W19665590092 @default.
• W1966559009 hasLocation W19665590093 @default.
• W1966559009 hasLocation W19665590094 @default.
• W1966559009 hasOpenAccess W1966559009 @default.
• W1966559009 hasPrimaryLocation W19665590091 @default.
• W1966559009 hasRelatedWork W1809349505 @default.
• W1966559009 hasRelatedWork W1946787458 @default.
• W1966559009 hasRelatedWork W1963937022 @default.
• W1966559009 hasRelatedWork W2021459535 @default.
• W1966559009 hasRelatedWork W2057924146 @default.

• next