Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966561569> ?p ?o ?g. }
- W1966561569 endingPage "1246" @default.
- W1966561569 startingPage "1242" @default.
- W1966561569 abstract "It is unknown what type of interstitial lung disease (ILD) has high risk for chemotherapy-related exacerbation of ILD. We investigated the risk of exacerbation of ILD for patients with lung cancer with ILD.One hundred nine patients with lung cancer with ILD treated with cytotoxic chemotherapy at Shizuoka Cancer Center between August 2002 and April 2010 were retrospectively reviewed.On pretreatment computed tomography (CT) of the chest, 69 patients (63%) were identified with usual interstitial pneumonia (UIP) pattern, and 40 patients (37%) had non-UIP pattern. Patients with UIP pattern developed cytotoxic chemotherapy-related exacerbation of ILD more frequently than those with non-UIP pattern (30 versus 8%, p = 0.005). The incidence of grade 5 pulmonary toxicities was 9% in patients with UIP pattern, compared with 3% in those with non-UIP pattern. Multivariate analyses demonstrated that age (<70 years) and CT pattern (UIP) were significant independent risk factors for cytotoxic chemotherapy-related exacerbation of ILD. In small cell lung cancer, overall survival (OS) from the start of first-line chemotherapy was significantly shorter in UIP pattern than non-UIP pattern (median OS: 9 versus 16 months, p = 0.0475), whereas there was no significant difference in patients with non-small cell lung cancer (median OS: 12 versus 9 months, p = 0.2529).Our results indicated that the incidence of exacerbation of ILD was significantly higher in patients with lung cancer with UIP pattern on CT findings than in those with non-UIP pattern. Therefore, great care is required when administering cytotoxic chemotherapy agents for patients with lung cancer with UIP pattern." @default.
- W1966561569 created "2016-06-24" @default.
- W1966561569 creator A5012542775 @default.
- W1966561569 creator A5014002661 @default.
- W1966561569 creator A5015604127 @default.
- W1966561569 creator A5016770292 @default.
- W1966561569 creator A5017887067 @default.
- W1966561569 creator A5020448557 @default.
- W1966561569 creator A5025707585 @default.
- W1966561569 creator A5032337115 @default.
- W1966561569 creator A5033780369 @default.
- W1966561569 creator A5051342257 @default.
- W1966561569 creator A5086023010 @default.
- W1966561569 creator A5089223839 @default.
- W1966561569 date "2011-07-01" @default.
- W1966561569 modified "2023-10-16" @default.
- W1966561569 title "The Risk of Cytotoxic Chemotherapy-Related Exacerbation of Interstitial Lung Disease with Lung Cancer" @default.
- W1966561569 cites W1770545381 @default.
- W1966561569 cites W1913616561 @default.
- W1966561569 cites W1924766221 @default.
- W1966561569 cites W1967649543 @default.
- W1966561569 cites W1968497370 @default.
- W1966561569 cites W1969869755 @default.
- W1966561569 cites W1988781537 @default.
- W1966561569 cites W1993946952 @default.
- W1966561569 cites W2009183164 @default.
- W1966561569 cites W2028109229 @default.
- W1966561569 cites W2039472941 @default.
- W1966561569 cites W2043275224 @default.
- W1966561569 cites W2053220020 @default.
- W1966561569 cites W2069015181 @default.
- W1966561569 cites W2094116236 @default.
- W1966561569 cites W2123982639 @default.
- W1966561569 cites W2132759338 @default.
- W1966561569 cites W2137748315 @default.
- W1966561569 cites W2138346322 @default.
- W1966561569 cites W2140923971 @default.
- W1966561569 cites W2141785470 @default.
- W1966561569 cites W2157869208 @default.
- W1966561569 cites W2166267091 @default.
- W1966561569 cites W2416914730 @default.
- W1966561569 doi "https://doi.org/10.1097/jto.0b013e318216ee6b" @default.
- W1966561569 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21623239" @default.
- W1966561569 hasPublicationYear "2011" @default.
- W1966561569 type Work @default.
- W1966561569 sameAs 1966561569 @default.
- W1966561569 citedByCount "162" @default.
- W1966561569 countsByYear W19665615692012 @default.
- W1966561569 countsByYear W19665615692013 @default.
- W1966561569 countsByYear W19665615692014 @default.
- W1966561569 countsByYear W19665615692015 @default.
- W1966561569 countsByYear W19665615692016 @default.
- W1966561569 countsByYear W19665615692017 @default.
- W1966561569 countsByYear W19665615692018 @default.
- W1966561569 countsByYear W19665615692019 @default.
- W1966561569 countsByYear W19665615692020 @default.
- W1966561569 countsByYear W19665615692021 @default.
- W1966561569 countsByYear W19665615692022 @default.
- W1966561569 countsByYear W19665615692023 @default.
- W1966561569 crossrefType "journal-article" @default.
- W1966561569 hasAuthorship W1966561569A5012542775 @default.
- W1966561569 hasAuthorship W1966561569A5014002661 @default.
- W1966561569 hasAuthorship W1966561569A5015604127 @default.
- W1966561569 hasAuthorship W1966561569A5016770292 @default.
- W1966561569 hasAuthorship W1966561569A5017887067 @default.
- W1966561569 hasAuthorship W1966561569A5020448557 @default.
- W1966561569 hasAuthorship W1966561569A5025707585 @default.
- W1966561569 hasAuthorship W1966561569A5032337115 @default.
- W1966561569 hasAuthorship W1966561569A5033780369 @default.
- W1966561569 hasAuthorship W1966561569A5051342257 @default.
- W1966561569 hasAuthorship W1966561569A5086023010 @default.
- W1966561569 hasAuthorship W1966561569A5089223839 @default.
- W1966561569 hasBestOaLocation W19665615691 @default.
- W1966561569 hasConcept C126322002 @default.
- W1966561569 hasConcept C143998085 @default.
- W1966561569 hasConcept C2776256026 @default.
- W1966561569 hasConcept C2776694085 @default.
- W1966561569 hasConcept C2777014857 @default.
- W1966561569 hasConcept C2777405647 @default.
- W1966561569 hasConcept C2777543607 @default.
- W1966561569 hasConcept C2777714996 @default.
- W1966561569 hasConcept C71924100 @default.
- W1966561569 hasConcept C90924648 @default.
- W1966561569 hasConceptScore W1966561569C126322002 @default.
- W1966561569 hasConceptScore W1966561569C143998085 @default.
- W1966561569 hasConceptScore W1966561569C2776256026 @default.
- W1966561569 hasConceptScore W1966561569C2776694085 @default.
- W1966561569 hasConceptScore W1966561569C2777014857 @default.
- W1966561569 hasConceptScore W1966561569C2777405647 @default.
- W1966561569 hasConceptScore W1966561569C2777543607 @default.
- W1966561569 hasConceptScore W1966561569C2777714996 @default.
- W1966561569 hasConceptScore W1966561569C71924100 @default.
- W1966561569 hasConceptScore W1966561569C90924648 @default.
- W1966561569 hasIssue "7" @default.
- W1966561569 hasLocation W19665615691 @default.
- W1966561569 hasLocation W19665615692 @default.
- W1966561569 hasOpenAccess W1966561569 @default.
- W1966561569 hasPrimaryLocation W19665615691 @default.