Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966562016> ?p ?o ?g. }
- W1966562016 endingPage "2561" @default.
- W1966562016 startingPage "2553" @default.
- W1966562016 abstract "Argonaute (Ago) proteins are essential for the biogenesis and function of ~ 20–30 nucleotide long RNAs such as microRNAs (miRNAs). Ago expression increases or decreases under various physiological conditions, although the functional consequences are unknown. In addition, while reduced global miRNA production was shown to enhance cellular transformation and tumorigenesis, how Ago proteins contribute to human diseases has not been reported. Ago2, an essential Ago isoform in mammals, was stably expressed in 293 T, the human embryonic kidney cell line, and H1299, the human lung adenocarcinoma cell line. miRNA and mRNA expression was investigated by quantitative PCR and microarray profiling. Cell proliferation and migration was examined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and scratch assay in the cell cultures, respectively. How Ago2 affected cell growth in vivo was determined by H1299 xenograft tumor growth in mice. Changes in Ago2 expression in human lung cancer samples were investigated by quantitative PCR and immunohistochemistry. Stable Ago2 overexpression elicited specific changes in miRNA and mRNA expression in both 293 T and H1299 cells. It also inhibited cell proliferation and migration in cell cultures as well as xenograft tumor growth in nude mice. Ago2 expression was lower in human lung adenocarcinomas than in the paired, non-cancerous tissues. We concluded that changes in Ago2 expression might have significant physiological and pathological consequences in vivo." @default.
- W1966562016 created "2016-06-24" @default.
- W1966562016 creator A5005157610 @default.
- W1966562016 creator A5006829574 @default.
- W1966562016 creator A5046023135 @default.
- W1966562016 date "2013-03-01" @default.
- W1966562016 modified "2023-10-18" @default.
- W1966562016 title "Overexpression of human Argonaute2 inhibits cell and tumor growth" @default.
- W1966562016 cites W1556166870 @default.
- W1966562016 cites W1985140771 @default.
- W1966562016 cites W1997932830 @default.
- W1966562016 cites W2010215928 @default.
- W1966562016 cites W2015428831 @default.
- W1966562016 cites W2019009111 @default.
- W1966562016 cites W2019167811 @default.
- W1966562016 cites W2021195009 @default.
- W1966562016 cites W2023372666 @default.
- W1966562016 cites W2030714059 @default.
- W1966562016 cites W2034203463 @default.
- W1966562016 cites W2034806022 @default.
- W1966562016 cites W2040191060 @default.
- W1966562016 cites W2042386784 @default.
- W1966562016 cites W2046486243 @default.
- W1966562016 cites W2062290101 @default.
- W1966562016 cites W2074106269 @default.
- W1966562016 cites W2074300285 @default.
- W1966562016 cites W2074664629 @default.
- W1966562016 cites W2085592081 @default.
- W1966562016 cites W2088756109 @default.
- W1966562016 cites W2100592123 @default.
- W1966562016 cites W2101543035 @default.
- W1966562016 cites W2102694589 @default.
- W1966562016 cites W2108402531 @default.
- W1966562016 cites W2112916657 @default.
- W1966562016 cites W2113321643 @default.
- W1966562016 cites W2118818674 @default.
- W1966562016 cites W2130410032 @default.
- W1966562016 cites W2130978704 @default.
- W1966562016 cites W2130979840 @default.
- W1966562016 cites W2131596261 @default.
- W1966562016 cites W2131876608 @default.
- W1966562016 cites W2135837360 @default.
- W1966562016 cites W2137649483 @default.
- W1966562016 cites W2142709908 @default.
- W1966562016 cites W2144038313 @default.
- W1966562016 cites W2144149602 @default.
- W1966562016 cites W2149848115 @default.
- W1966562016 cites W2149930662 @default.
- W1966562016 cites W2158605421 @default.
- W1966562016 cites W2172157901 @default.
- W1966562016 cites W2172207274 @default.
- W1966562016 cites W2910065277 @default.
- W1966562016 doi "https://doi.org/10.1016/j.bbagen.2012.11.013" @default.
- W1966562016 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23201202" @default.
- W1966562016 hasPublicationYear "2013" @default.
- W1966562016 type Work @default.
- W1966562016 sameAs 1966562016 @default.
- W1966562016 citedByCount "28" @default.
- W1966562016 countsByYear W19665620162012 @default.
- W1966562016 countsByYear W19665620162013 @default.
- W1966562016 countsByYear W19665620162014 @default.
- W1966562016 countsByYear W19665620162015 @default.
- W1966562016 countsByYear W19665620162016 @default.
- W1966562016 countsByYear W19665620162017 @default.
- W1966562016 countsByYear W19665620162018 @default.
- W1966562016 countsByYear W19665620162020 @default.
- W1966562016 countsByYear W19665620162021 @default.
- W1966562016 countsByYear W19665620162022 @default.
- W1966562016 crossrefType "journal-article" @default.
- W1966562016 hasAuthorship W1966562016A5005157610 @default.
- W1966562016 hasAuthorship W1966562016A5006829574 @default.
- W1966562016 hasAuthorship W1966562016A5046023135 @default.
- W1966562016 hasConcept C104317684 @default.
- W1966562016 hasConcept C119056186 @default.
- W1966562016 hasConcept C121608353 @default.
- W1966562016 hasConcept C145059251 @default.
- W1966562016 hasConcept C1491633281 @default.
- W1966562016 hasConcept C153911025 @default.
- W1966562016 hasConcept C201853390 @default.
- W1966562016 hasConcept C22615655 @default.
- W1966562016 hasConcept C29537977 @default.
- W1966562016 hasConcept C502942594 @default.
- W1966562016 hasConcept C54009773 @default.
- W1966562016 hasConcept C54355233 @default.
- W1966562016 hasConcept C555283112 @default.
- W1966562016 hasConcept C62112901 @default.
- W1966562016 hasConcept C81885089 @default.
- W1966562016 hasConcept C86803240 @default.
- W1966562016 hasConcept C95444343 @default.
- W1966562016 hasConceptScore W1966562016C104317684 @default.
- W1966562016 hasConceptScore W1966562016C119056186 @default.
- W1966562016 hasConceptScore W1966562016C121608353 @default.
- W1966562016 hasConceptScore W1966562016C145059251 @default.
- W1966562016 hasConceptScore W1966562016C1491633281 @default.
- W1966562016 hasConceptScore W1966562016C153911025 @default.
- W1966562016 hasConceptScore W1966562016C201853390 @default.
- W1966562016 hasConceptScore W1966562016C22615655 @default.
- W1966562016 hasConceptScore W1966562016C29537977 @default.