FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966565364> ?p ?o ?g. }

• W1966565364 endingPage "1012" @default.
• W1966565364 startingPage "997" @default.
• W1966565364 abstract "A decrease in the number of nicotinic-acetylcholine receptors (nAChRs) in the brain is thought to contribute to the cognitive dysfunction associated with diseases as diverse as Alzheimer's disease and schizophrenia. Interestingly, nicotine and similar compounds have been shown to enhance memory function and increase the expression of nAChRs and therefore, could have a therapeutic role in the aforementioned diseases. Nicotine has also been shown to exert positive effects on certain neurotrophins such as nerve growth factor (NGF), and therefore could play a role beyond mere symptomatic therapy. However, to date, comprehensive studies of nicotine's effects on the expression of specific acetylcholine (ACh) receptor subtypes, key cholinergic proteins (that are regulated by NGF) such as choline acetyltransferase (ChAT) and the vesicular ACh transporter (VAChT) are lacking. Studies to further investigate the effects of nicotine on NGF especially its high- and low-affinity receptors are also needed. In the present study, male Wistar rats exposed a relatively low dosage of nicotine (0.35 mg/kg every 12 h) for 14 days demonstrated improved memory performance (assessed in two separate water maze testing methods) when compared with controls. Autoradiographic experiments indicated that nicotine increased [3H]-epibatidine, [125I]-alpha-bungarotoxin and [3H]-AFDX384, but not [3H]-pirenzepine binding sites in several learning- and memory-related brain areas. The expression of ChAT, VAChT, as well as tropomyosin-receptor kinase A (TrkA) NGF receptors and phospho-TrK receptors was increased by nicotine in the hippocampus. No changes were observed in the levels of the NGF peptide or low affinity p75 neurotrophin receptors (p75NTR), however. These results suggest that repeated exposure to nicotine results in positive effects on central cholinergic markers and memory function, which may be mediated via effects on high-affinity NGF receptors." @default.
• W1966565364 created "2016-06-24" @default.
• W1966565364 creator A5028964250 @default.
• W1966565364 creator A5079134355 @default.
• W1966565364 date "2005-01-01" @default.
• W1966565364 modified "2023-09-25" @default.
• W1966565364 title "Repeated nicotine exposure in rats: Effects on memory function, cholinergic markers and nerve growth factor" @default.
• W1966565364 cites W1518922051 @default.
• W1966565364 cites W1528356353 @default.
• W1966565364 cites W1585413892 @default.
• W1966565364 cites W1603286332 @default.
• W1966565364 cites W173428210 @default.
• W1966565364 cites W1964469240 @default.
• W1966565364 cites W1970382190 @default.
• W1966565364 cites W1970486150 @default.
• W1966565364 cites W197352837 @default.
• W1966565364 cites W1974018894 @default.
• W1966565364 cites W1976873927 @default.
• W1966565364 cites W1977150341 @default.
• W1966565364 cites W1978071150 @default.
• W1966565364 cites W1978663880 @default.
• W1966565364 cites W1979212481 @default.
• W1966565364 cites W1984034731 @default.
• W1966565364 cites W1985313555 @default.
• W1966565364 cites W1987757645 @default.
• W1966565364 cites W1989161392 @default.
• W1966565364 cites W1989920581 @default.
• W1966565364 cites W1995689810 @default.
• W1966565364 cites W1998815060 @default.
• W1966565364 cites W2001565143 @default.
• W1966565364 cites W2003018102 @default.
• W1966565364 cites W2003726198 @default.
• W1966565364 cites W2010806189 @default.
• W1966565364 cites W2010936735 @default.
• W1966565364 cites W2012474406 @default.
• W1966565364 cites W2012745495 @default.
• W1966565364 cites W2015426057 @default.
• W1966565364 cites W2021139758 @default.
• W1966565364 cites W2021862627 @default.
• W1966565364 cites W2022682759 @default.
• W1966565364 cites W2025022649 @default.
• W1966565364 cites W2026588006 @default.
• W1966565364 cites W2027036629 @default.
• W1966565364 cites W2030470449 @default.
• W1966565364 cites W2032524839 @default.
• W1966565364 cites W2032551306 @default.
• W1966565364 cites W2033817042 @default.
• W1966565364 cites W2034029496 @default.
• W1966565364 cites W2037663306 @default.
• W1966565364 cites W2045309216 @default.
• W1966565364 cites W2045621697 @default.
• W1966565364 cites W2047290727 @default.
• W1966565364 cites W2048254981 @default.
• W1966565364 cites W2054628630 @default.
• W1966565364 cites W2061475648 @default.
• W1966565364 cites W2063464055 @default.
• W1966565364 cites W2066093836 @default.
• W1966565364 cites W2068537376 @default.
• W1966565364 cites W2069629919 @default.
• W1966565364 cites W2070644314 @default.
• W1966565364 cites W2073661142 @default.
• W1966565364 cites W2076583086 @default.
• W1966565364 cites W2085605392 @default.
• W1966565364 cites W2087633151 @default.
• W1966565364 cites W2089075278 @default.
• W1966565364 cites W2091224498 @default.
• W1966565364 cites W2118977349 @default.
• W1966565364 cites W2131003664 @default.
• W1966565364 cites W2169473035 @default.
• W1966565364 cites W2169858234 @default.
• W1966565364 cites W2170030276 @default.
• W1966565364 cites W2330956224 @default.
• W1966565364 cites W247473604 @default.
• W1966565364 cites W4293247451 @default.
• W1966565364 cites W4362206873 @default.
• W1966565364 cites W2185011055 @default.
• W1966565364 doi "https://doi.org/10.1016/j.neuroscience.2004.10.006" @default.
• W1966565364 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15652996" @default.
• W1966565364 hasPublicationYear "2005" @default.
• W1966565364 type Work @default.
• W1966565364 sameAs 1966565364 @default.
• W1966565364 citedByCount "97" @default.
• W1966565364 countsByYear W19665653642012 @default.
• W1966565364 countsByYear W19665653642013 @default.
• W1966565364 countsByYear W19665653642014 @default.
• W1966565364 countsByYear W19665653642015 @default.
• W1966565364 countsByYear W19665653642016 @default.
• W1966565364 countsByYear W19665653642017 @default.
• W1966565364 countsByYear W19665653642018 @default.
• W1966565364 countsByYear W19665653642019 @default.
• W1966565364 countsByYear W19665653642020 @default.
• W1966565364 countsByYear W19665653642021 @default.
• W1966565364 countsByYear W19665653642023 @default.
• W1966565364 crossrefType "journal-article" @default.
• W1966565364 hasAuthorship W1966565364A5028964250 @default.
• W1966565364 hasAuthorship W1966565364A5079134355 @default.
• W1966565364 hasConcept C104966671 @default.
• W1966565364 hasConcept C126322002 @default.

• next