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- W1966582010 abstract "We developed a software program, NDesign, for the design of a study intended for detecting rare variants from next-generation sequencing (NGS) data. In this study design, the optimal depth of coverage and the average depth of coverage are first evaluated, and then the ability of the designed experiment to obtain a desired power is determined. NDesign has been developed to calculate both these depths, as well as to evaluate the power of the designed experiment. It has a simple implementation in the JavaScript language, and is expected to enable researchers to design optimal NGS studies." @default.
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- W1966582010 date "2012-07-12" @default.
- W1966582010 modified "2023-10-16" @default.
- W1966582010 title "NDesign: software for study design for the detection of rare variants from next-generation sequencing data" @default.
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- W1966582010 doi "https://doi.org/10.1038/jhg.2012.81" @default.
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