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- W1966584097 abstract "[1,2,3]-Triazole derivatives of nor-beta-lapachone were synthesized and assayed against the infective bloodstream trypomastigote form of Trypanosoma cruzi, the etiological agent of Chagas disease. All the derivatives were more active than the original quinones, with IC(50)/1 day values in the range of 17 to 359 microM, the apolar phenyl substituted triazole 6 being the most active compound. These triazole derivatives of nor-beta-lapachone emerge as interesting new lead compounds in drug development for Chagas disease." @default.
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- W1966584097 date "2008-08-01" @default.
- W1966584097 modified "2023-10-01" @default.
- W1966584097 title "Naphthoquinoidal [1,2,3]-triazole, a new structural moiety active against Trypanosoma cruzi" @default.
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- W1966584097 doi "https://doi.org/10.1016/j.ejmech.2007.10.015" @default.
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