Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966594516> ?p ?o ?g. }
Showing items 1 to 63 of
63
with 100 items per page.
- W1966594516 endingPage "474" @default.
- W1966594516 startingPage "474" @default.
- W1966594516 abstract "THE transformation of cholesterol into coprosterol in its passage through the body involves a reduction of the C5:C6 double bond, and a transition from the allocholanic—to the cholanic-ring system. Although it is established that the bacterial flora of the intestine is concerned in the reduction process, the mechanism by which the stereochemical change is brought about is unknown. A clue was afforded by a study of the properties of cholestene—3:4—diol, a primary oxidation product which is formed under various conditions of mild oxidation from cholesterol, and is also a constituent of the resinous product called oxycholesterol1. Being an glycol, this substance easily rearranges by loss of water into the corresponding ketone, that is, cholestenone. Since cholestenone (= coprostenone) yields coprostanone on reduction, which in turn is reducible to coprosterol (= coprostanol) and epi-coprosterol2,3, we formed the working hypothesis that the reactive primary oxidation product, cholestene-diol, may play a role in cholesterol metabolism, giving rise to the formation of cholestenone as an intermediary product. On this assumption, cholestenone and coprostanone, and not cholesterol itself, are the immediate precursors of coprosterol which is formed from them in the intestine by bacterial reduction. Further, an explanation is afforded for the origin of the epi-hydroxycholane system in lithocholic acid (and the other bile acids?)4, which may be derived from epi-coprosterol by oxidative cleavage of the side chain with loss of acetone." @default.
- W1966594516 created "2016-06-24" @default.
- W1966594516 creator A5077396054 @default.
- W1966594516 creator A5089437073 @default.
- W1966594516 date "1935-09-01" @default.
- W1966594516 modified "2023-10-17" @default.
- W1966594516 title "Precursors of Coprosterol and the Bile Acids in the Animal Organism" @default.
- W1966594516 cites W2040361482 @default.
- W1966594516 cites W2090937154 @default.
- W1966594516 cites W2321593346 @default.
- W1966594516 cites W4250034528 @default.
- W1966594516 doi "https://doi.org/10.1038/136474a0" @default.
- W1966594516 hasPublicationYear "1935" @default.
- W1966594516 type Work @default.
- W1966594516 sameAs 1966594516 @default.
- W1966594516 citedByCount "27" @default.
- W1966594516 countsByYear W19665945162015 @default.
- W1966594516 countsByYear W19665945162020 @default.
- W1966594516 countsByYear W19665945162021 @default.
- W1966594516 countsByYear W19665945162023 @default.
- W1966594516 crossrefType "journal-article" @default.
- W1966594516 hasAuthorship W1966594516A5077396054 @default.
- W1966594516 hasAuthorship W1966594516A5089437073 @default.
- W1966594516 hasBestOaLocation W19665945161 @default.
- W1966594516 hasConcept C178790620 @default.
- W1966594516 hasConcept C185592680 @default.
- W1966594516 hasConcept C204921945 @default.
- W1966594516 hasConcept C2778163477 @default.
- W1966594516 hasConcept C2779399885 @default.
- W1966594516 hasConcept C2780420665 @default.
- W1966594516 hasConcept C521977710 @default.
- W1966594516 hasConcept C55493867 @default.
- W1966594516 hasConcept C71240020 @default.
- W1966594516 hasConceptScore W1966594516C178790620 @default.
- W1966594516 hasConceptScore W1966594516C185592680 @default.
- W1966594516 hasConceptScore W1966594516C204921945 @default.
- W1966594516 hasConceptScore W1966594516C2778163477 @default.
- W1966594516 hasConceptScore W1966594516C2779399885 @default.
- W1966594516 hasConceptScore W1966594516C2780420665 @default.
- W1966594516 hasConceptScore W1966594516C521977710 @default.
- W1966594516 hasConceptScore W1966594516C55493867 @default.
- W1966594516 hasConceptScore W1966594516C71240020 @default.
- W1966594516 hasIssue "3438" @default.
- W1966594516 hasLocation W19665945161 @default.
- W1966594516 hasOpenAccess W1966594516 @default.
- W1966594516 hasPrimaryLocation W19665945161 @default.
- W1966594516 hasRelatedWork W1965399349 @default.
- W1966594516 hasRelatedWork W1965503535 @default.
- W1966594516 hasRelatedWork W2007400363 @default.
- W1966594516 hasRelatedWork W2021421778 @default.
- W1966594516 hasRelatedWork W2079439938 @default.
- W1966594516 hasRelatedWork W2137961868 @default.
- W1966594516 hasRelatedWork W2171700348 @default.
- W1966594516 hasRelatedWork W2321989153 @default.
- W1966594516 hasRelatedWork W2334694569 @default.
- W1966594516 hasRelatedWork W3215889351 @default.
- W1966594516 hasVolume "136" @default.
- W1966594516 isParatext "false" @default.
- W1966594516 isRetracted "false" @default.
- W1966594516 magId "1966594516" @default.
- W1966594516 workType "article" @default.