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• W1966596114 abstract "Gelatin microspheres containing recombinant human interferon αA/D (A/D-IFN) (IFN-microspheres) potentiated the antitumor activity of mouse peritoneal macrophages (Mφo) much more efficiently than free A/D-IFN. Mφo acquired the inhibitory activity on tumor cell growth by the ingestion of IFN-microspheres without the aid of lipopolysaccharide (LPS), though LPS was required as a second signal for activating Mφo primed with free IFN. The IFN-microspheres were much more efficient than free IFN plus LFS in respect of the IFN amount and the time required for Mφo activation. Furthermore, Mφo pretreated with the IFN-microspheres maintained their activated state for a much longer period than those pretreated with free A/D-IFN plus LPS. A monoclonal anti-IFN-αA antibody, which was capable of neutralizing A/D-IFN, did not interfere with the Mφo activation by the IFN-microspheres. Even human IFN-αA was effective in activating murine Mφo similarly to A/D-IFN, when given in the form of IFN-microspheres, though human IFN-αA in the free form was ineffective. These results argue that the mechanism of Mφo activation by the IFN-microspheres is different from that by free IFN." @default.
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• W1966596114 date "1988-05-01" @default.
• W1966596114 modified "2023-10-16" @default.
• W1966596114 title "Potentiation of Antitumor Activity of Macrophages by Recombinant Interferon Alpha A/D Contained in Gelatin Microspheres" @default.
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• W1966596114 doi "https://doi.org/10.1111/j.1349-7006.1988.tb00034.x" @default.
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