FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966596315> ?p ?o ?g. }

• W1966596315 endingPage "181" @default.
• W1966596315 startingPage "175" @default.
• W1966596315 abstract "The effects of 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] and its analogue 22-oxa-1,25(OH)2D3 (22-oxacalcitriol) (OCT) on calcium and bone metabolism were examined in an animal model of hypercalcemia with continuous infusion of parathyroid hormone-related peptide (PTHrP), to determine whether active vitamin D could counteract the skeletal action of PTHrP in addition to its reported effect in suppressing the production of PTHrP in cancer cells. Parathyroid glands were removed from 8-week-old Sprague-Dawley rats to eliminate the confounding effects of endogenous PTH. Animals were then continuously infused with human PTHrP(1-34) at a constant rate via osmotic minipumps for 2 weeks, and at the same time treated orally or intravenously with OCT or 1,25(OH)2D3 four to nine times during the 2-week period. Under these conditions, OCT and, surprisingly, 1,25(OH)2D3 alleviated hypercalcemia in a dose-dependent manner. 1,25(OH)2D3 and OCT suppressed the urinary excretion of deoxypyridinoline, although they did not affect renal calcium handling, suggesting that the antihypercalcemic effect is attributable to the inhibition of bone resorption. These active vitamin D compounds also counteracted the effects of PTHrP at the proximal renal tubules, as reflected by a decrease in phosphate excretion. Histomorphometric analysis of bone revealed a dose-related decrease in parameters of bone resorption. These results suggest that 1,25(OH)2D3 as well as OCT has the potential to alleviate hypercalcemia, at least in part, through the inhibition of bone resorption in hypercalcemic rats with constant PTHrP levels. We propose that the main function of active vitamin D in high bone-turnover states is to inhibit bone resorption, and this may have important implications for the understanding of the role of active vitamin D in the treatment of metabolic bone diseases, such as osteoporosis." @default.
• W1966596315 created "2016-06-24" @default.
• W1966596315 creator A5023108113 @default.
• W1966596315 creator A5023449950 @default.
• W1966596315 creator A5036280254 @default.
• W1966596315 creator A5044061030 @default.
• W1966596315 creator A5070557428 @default.
• W1966596315 creator A5071367814 @default.
• W1966596315 creator A5077488995 @default.
• W1966596315 creator A5088773176 @default.
• W1966596315 date "2000-01-01" @default.
• W1966596315 modified "2023-10-10" @default.
• W1966596315 title "1,25-Dihydroxyvitamin D3 as Well as Its Analogue OCT Lower Blood Calcium Through Inhibition of Bone Resorption in Hypercalcemic Rats with Continuous Parathyroid Hormone-Related Peptide Infusion" @default.
• W1966596315 cites W1498693984 @default.
• W1966596315 cites W1521003662 @default.
• W1966596315 cites W1566820762 @default.
• W1966596315 cites W1570858759 @default.
• W1966596315 cites W1965551846 @default.
• W1966596315 cites W1969429995 @default.
• W1966596315 cites W1986392434 @default.
• W1966596315 cites W1987375466 @default.
• W1966596315 cites W1990783720 @default.
• W1966596315 cites W2032605743 @default.
• W1966596315 cites W2042567846 @default.
• W1966596315 cites W2043477138 @default.
• W1966596315 cites W2047231268 @default.
• W1966596315 cites W2048299560 @default.
• W1966596315 cites W2074280516 @default.
• W1966596315 cites W2087378917 @default.
• W1966596315 cites W2092973229 @default.
• W1966596315 cites W2139996507 @default.
• W1966596315 cites W2171765698 @default.
• W1966596315 cites W2278405325 @default.
• W1966596315 cites W4239381756 @default.
• W1966596315 doi "https://doi.org/10.1359/jbmr.2000.15.1.175" @default.
• W1966596315 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10646127" @default.
• W1966596315 hasPublicationYear "2000" @default.
• W1966596315 type Work @default.
• W1966596315 sameAs 1966596315 @default.
• W1966596315 citedByCount "36" @default.
• W1966596315 countsByYear W19665963152013 @default.
• W1966596315 countsByYear W19665963152014 @default.
• W1966596315 countsByYear W19665963152016 @default.
• W1966596315 crossrefType "journal-article" @default.
• W1966596315 hasAuthorship W1966596315A5023108113 @default.
• W1966596315 hasAuthorship W1966596315A5023449950 @default.
• W1966596315 hasAuthorship W1966596315A5036280254 @default.
• W1966596315 hasAuthorship W1966596315A5044061030 @default.
• W1966596315 hasAuthorship W1966596315A5070557428 @default.
• W1966596315 hasAuthorship W1966596315A5071367814 @default.
• W1966596315 hasAuthorship W1966596315A5077488995 @default.
• W1966596315 hasAuthorship W1966596315A5088773176 @default.
• W1966596315 hasBestOaLocation W19665963151 @default.
• W1966596315 hasConcept C124490489 @default.
• W1966596315 hasConcept C126322002 @default.
• W1966596315 hasConcept C131075544 @default.
• W1966596315 hasConcept C134018914 @default.
• W1966596315 hasConcept C146562846 @default.
• W1966596315 hasConcept C160160445 @default.
• W1966596315 hasConcept C170033053 @default.
• W1966596315 hasConcept C181199279 @default.
• W1966596315 hasConcept C185592680 @default.
• W1966596315 hasConcept C2776079296 @default.
• W1966596315 hasConcept C2780787237 @default.
• W1966596315 hasConcept C2781208988 @default.
• W1966596315 hasConcept C519063684 @default.
• W1966596315 hasConcept C55493867 @default.
• W1966596315 hasConcept C673006 @default.
• W1966596315 hasConcept C71924100 @default.
• W1966596315 hasConcept C87975464 @default.
• W1966596315 hasConceptScore W1966596315C124490489 @default.
• W1966596315 hasConceptScore W1966596315C126322002 @default.
• W1966596315 hasConceptScore W1966596315C131075544 @default.
• W1966596315 hasConceptScore W1966596315C134018914 @default.
• W1966596315 hasConceptScore W1966596315C146562846 @default.
• W1966596315 hasConceptScore W1966596315C160160445 @default.
• W1966596315 hasConceptScore W1966596315C170033053 @default.
• W1966596315 hasConceptScore W1966596315C181199279 @default.
• W1966596315 hasConceptScore W1966596315C185592680 @default.
• W1966596315 hasConceptScore W1966596315C2776079296 @default.
• W1966596315 hasConceptScore W1966596315C2780787237 @default.
• W1966596315 hasConceptScore W1966596315C2781208988 @default.
• W1966596315 hasConceptScore W1966596315C519063684 @default.
• W1966596315 hasConceptScore W1966596315C55493867 @default.
• W1966596315 hasConceptScore W1966596315C673006 @default.
• W1966596315 hasConceptScore W1966596315C71924100 @default.
• W1966596315 hasConceptScore W1966596315C87975464 @default.
• W1966596315 hasIssue "1" @default.
• W1966596315 hasLocation W19665963151 @default.
• W1966596315 hasLocation W19665963152 @default.
• W1966596315 hasOpenAccess W1966596315 @default.
• W1966596315 hasPrimaryLocation W19665963151 @default.
• W1966596315 hasRelatedWork W1953815681 @default.
• W1966596315 hasRelatedWork W1971432874 @default.
• W1966596315 hasRelatedWork W1983660056 @default.
• W1966596315 hasRelatedWork W2009795551 @default.
• W1966596315 hasRelatedWork W2033892914 @default.
• W1966596315 hasRelatedWork W2038159208 @default.

• next