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- W1966609546 abstract "Two cDNA clones encoding α and β subunits of soluble guanylyl cyclase (GC) were isolated from medaka fish (Oryzias latipes) cDNA libraries and designated as OlGCS-α1 and OlGCS-β1, respectively. The ORF of OlGCS-α1 encodes 678 amino acids and that of OlGCS-β1 encodes 614 amino acids. Both subunits have a putative catalytic domain conserved with membrane GC and adenylyl cyclases. The amino acid sequences of OlGCS-β1 and mammalian soluble GC subunits are highly conserved throughout the entire protein, suggesting that amino acid sequences outside the catalytic domain are important for the functioning of the β subunit. On the contrary, amino acid sequences of α subunits outside the catalytic domain are fairly divergent between fish and mammals. Reverse transcription/PCR (RT/PCR) analysis showed that OlGCS-α1 and OlGCS-β1 transcripts were abundant in the brain, eye, spleen and testis. RT/PCR analysis demonstrated that both transcripts were present in unfertilized eggs, were reduced immediately after fertilization, then increased again. In addition, our results suggest that expression patterns of OlGCS-α1 and OlGCS-β1 genes are different from each other both during development and in adults." @default.
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- W1966609546 date "1998-04-01" @default.
- W1966609546 modified "2023-10-15" @default.
- W1966609546 title "Molecular cloning of cDNAs and expression of mRNAs encoding alpha and beta subunits of soluble guanylyl cyclase from medaka fish Oryzias latipes" @default.
- W1966609546 doi "https://doi.org/10.1046/j.1432-1327.1998.2530042.x" @default.
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