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- W1966610133 abstract "The 11‐ cis ‐retinol dehydrogenase (11‐ cis ‐RoDH) gene encodes the short‐chain alcohol dehydrogenase responsible for 11‐ cis ‐retinol oxidation in the visual cycle. The structure of the murine 11‐ cis ‐RoDH gene was used to reinvestigate its transcription pattern. An 11‐ cis ‐RoDH gene transcript was detected in several non‐ocular tissues. The question regarding the substrate specificity of the enzyme was therefore addressed. Recombinant 11‐ cis ‐RoDH was found capable of oxidizing and reducing 9‐ cis ‐, 11‐ cis ‐ and 13‐ cis ‐isomers of retinol and retinaldehyde, respectively. Dodecyl‐β‐1‐maltoside used to solubilize the enzyme was found to affect the substrate specificity. This is the first report on a visual cycle enzyme also present in non‐retinal ocular and non‐ocular tissues. A possible role in addition to its role in the visual cycle is being discussed." @default.
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- W1966610133 date "1998-05-29" @default.
- W1966610133 modified "2023-09-25" @default.
- W1966610133 title "The visual cycle retinol dehydrogenase: possible involvement in the 9-<i>cis</i>retinoic acid biosynthetic pathway" @default.
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- W1966610133 doi "https://doi.org/10.1016/s0014-5793(98)00473-6" @default.
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