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- W1966621812 endingPage "1144" @default.
- W1966621812 startingPage "1132" @default.
- W1966621812 abstract "Signal transfer in neural circuits is dynamically modified by the recent history of neuronal activity. Short-term plasticity endows synapses with nonlinear transmission properties, yet synapses in sensory and motor circuits are capable of signaling linearly over a wide range of presynaptic firing rates. How do such synapses achieve rate-invariant transmission despite history-dependent nonlinearities? Here, ultrastructural, biophysical, and computational analyses demonstrate that concerted molecular, anatomical, and physiological refinements are required for central vestibular nerve synapses to linearly transmit rate-coded sensory signals. Vestibular synapses operate in a physiological regime of steady-state depression imposed by tonic firing. Rate-invariant transmission relies on brief presynaptic action potentials that delimit calcium influx, large pools of rapidly mobilized vesicles, multiple low-probability release sites, robust postsynaptic receptor sensitivity, and efficient transmitter clearance. Broadband linear synaptic filtering of head motion signals is thus achieved by coordinately tuned synaptic machinery that maintains physiological operation within inherent cell biological limitations." @default.
- W1966621812 created "2016-06-24" @default.
- W1966621812 creator A5034274369 @default.
- W1966621812 creator A5041448701 @default.
- W1966621812 creator A5087053208 @default.
- W1966621812 creator A5087353199 @default.
- W1966621812 creator A5088229655 @default.
- W1966621812 date "2015-03-01" @default.
- W1966621812 modified "2023-10-18" @default.
- W1966621812 title "Implementation of Linear Sensory Signaling via Multiple Coordinated Mechanisms at Central Vestibular Nerve Synapses" @default.
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