FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966622018> ?p ?o ?g. }

• W1966622018 endingPage "3673" @default.
• W1966622018 startingPage "3664" @default.
• W1966622018 abstract "The DNA binding of cationic complexes of the type [(η6-arene)Ru(Aa)(dppz)] (CF3SO3)n (arene = C6H6, Me3C6H3, C6Me6; dppz = dipyrido[3,2-a:2′,3′-c]phenazine; n = 1, Aa = AcH−1cysOH 4–6; n = 2, Aa = AcmetOH 7–9; n = 3, Aa = H2metOMe 10–12) containing S-coordinated amino acids (HcysOH = L-cysteine, HmetOH = L-methionine) has been studied by UV-vis titration and 2D-NOESY. Stable intercalative binding is indicated for these complexes by their steady decrease in absorbance at maxima between 350 and 390 nm on titration with CT DNA and the bathochromic shifts of these absorption maxima. Taking 4–12 and the analogous (η6-C6Me6)RuII complexes of the tripeptides HglyglycysOH (n =1, 13) and HglyglymetOH (n = 2, 15; HglyOH = glycine) into account, typical DNA binding constant (Kb) ranges can be established for (η6-arene)RuII complexes: 5.3 × 104–1.6 × 105 M−1 for monocations, 6.3 × 105–9.9 × 105 M−1 for dications and 1.6 × 106–5.5 × 106 M−1 for trications. These Kb values clearly reflect a strengthening of electrostatic interactions with the negatively charged phosphodiester backbone of DNA as the total cation charge increases. A consistent trend to higher Kb values is also apparent for the coligand series C6H6 < Me3C6H3 < C6Me6 with the relative increase being, in general, more pronounced for C6H6/Me3C6H3 pairs. The strong electronic influence of the coligand on dppz intercalation is also reflected by marked increases ΔTm of 18.2–18.5 °C in the CT DNA thermal denaturation temperature for di- and tri-cationic (η6-C6Me6)RuII complexes. Upfield 1H NMR chemical shifts and characteristic NOE cross peaks for the dppz protons of the 1 ∶ 1 complex formed between 9 and d(GTCGAC)2 are consistent with a side-on intercalation adjacent to T2 from the major groove." @default.
• W1966622018 created "2016-06-24" @default.
• W1966622018 creator A5030546820 @default.
• W1966622018 creator A5045546872 @default.
• W1966622018 creator A5090679678 @default.
• W1966622018 date "2002-01-01" @default.
• W1966622018 modified "2023-09-25" @default.
• W1966622018 title "Coligand tuning of the DNA binding properties of bioorganometallic (η⁶-arene)ruthenium(<scp>ii</scp>) complexes of the type [(η⁶-arene)Ru(amino acid)(dppz)]ⁿ⁺ (dppz = dipyrido[3,2-a:2′,3′-c]phenazine), n = 1–3" @default.
• W1966622018 cites W1969430317 @default.
• W1966622018 cites W1969509030 @default.
• W1966622018 cites W1981008773 @default.
• W1966622018 cites W1988094249 @default.
• W1966622018 cites W1997532254 @default.
• W1966622018 cites W2002338086 @default.
• W1966622018 cites W2005022182 @default.
• W1966622018 cites W2005252051 @default.
• W1966622018 cites W2011436915 @default.
• W1966622018 cites W2013962480 @default.
• W1966622018 cites W2014761544 @default.
• W1966622018 cites W2017346763 @default.
• W1966622018 cites W2020107720 @default.
• W1966622018 cites W2020995043 @default.
• W1966622018 cites W2032427906 @default.
• W1966622018 cites W2033083998 @default.
• W1966622018 cites W2034175316 @default.
• W1966622018 cites W2038124483 @default.
• W1966622018 cites W2038822441 @default.
• W1966622018 cites W2041486892 @default.
• W1966622018 cites W2042062103 @default.
• W1966622018 cites W2047093276 @default.
• W1966622018 cites W2055160328 @default.
• W1966622018 cites W2059416161 @default.
• W1966622018 cites W2064885067 @default.
• W1966622018 cites W2065868015 @default.
• W1966622018 cites W2069364101 @default.
• W1966622018 cites W2070278984 @default.
• W1966622018 cites W2073380384 @default.
• W1966622018 cites W2080658291 @default.
• W1966622018 cites W2128294421 @default.
• W1966622018 cites W2161425762 @default.
• W1966622018 cites W2952222449 @default.
• W1966622018 cites W2952384035 @default.
• W1966622018 cites W74691089 @default.
• W1966622018 doi "https://doi.org/10.1039/b203569n" @default.
• W1966622018 hasPublicationYear "2002" @default.
• W1966622018 type Work @default.
• W1966622018 sameAs 1966622018 @default.
• W1966622018 citedByCount "59" @default.
• W1966622018 countsByYear W19666220182012 @default.
• W1966622018 countsByYear W19666220182013 @default.
• W1966622018 countsByYear W19666220182014 @default.
• W1966622018 countsByYear W19666220182016 @default.
• W1966622018 countsByYear W19666220182017 @default.
• W1966622018 countsByYear W19666220182018 @default.
• W1966622018 countsByYear W19666220182019 @default.
• W1966622018 countsByYear W19666220182022 @default.
• W1966622018 countsByYear W19666220182023 @default.
• W1966622018 crossrefType "journal-article" @default.
• W1966622018 hasAuthorship W1966622018A5030546820 @default.
• W1966622018 hasAuthorship W1966622018A5045546872 @default.
• W1966622018 hasAuthorship W1966622018A5090679678 @default.
• W1966622018 hasConcept C121332964 @default.
• W1966622018 hasConcept C137824038 @default.
• W1966622018 hasConcept C161790260 @default.
• W1966622018 hasConcept C178790620 @default.
• W1966622018 hasConcept C179104552 @default.
• W1966622018 hasConcept C184866935 @default.
• W1966622018 hasConcept C185592680 @default.
• W1966622018 hasConcept C2776513212 @default.
• W1966622018 hasConcept C2777691172 @default.
• W1966622018 hasConcept C2778370995 @default.
• W1966622018 hasConcept C46051903 @default.
• W1966622018 hasConcept C552990157 @default.
• W1966622018 hasConcept C55493867 @default.
• W1966622018 hasConcept C555196967 @default.
• W1966622018 hasConcept C62520636 @default.
• W1966622018 hasConcept C71240020 @default.
• W1966622018 hasConcept C8010536 @default.
• W1966622018 hasConcept C91881484 @default.
• W1966622018 hasConceptScore W1966622018C121332964 @default.
• W1966622018 hasConceptScore W1966622018C137824038 @default.
• W1966622018 hasConceptScore W1966622018C161790260 @default.
• W1966622018 hasConceptScore W1966622018C178790620 @default.
• W1966622018 hasConceptScore W1966622018C179104552 @default.
• W1966622018 hasConceptScore W1966622018C184866935 @default.
• W1966622018 hasConceptScore W1966622018C185592680 @default.
• W1966622018 hasConceptScore W1966622018C2776513212 @default.
• W1966622018 hasConceptScore W1966622018C2777691172 @default.
• W1966622018 hasConceptScore W1966622018C2778370995 @default.
• W1966622018 hasConceptScore W1966622018C46051903 @default.
• W1966622018 hasConceptScore W1966622018C552990157 @default.
• W1966622018 hasConceptScore W1966622018C55493867 @default.
• W1966622018 hasConceptScore W1966622018C555196967 @default.
• W1966622018 hasConceptScore W1966622018C62520636 @default.
• W1966622018 hasConceptScore W1966622018C71240020 @default.
• W1966622018 hasConceptScore W1966622018C8010536 @default.
• W1966622018 hasConceptScore W1966622018C91881484 @default.
• W1966622018 hasIssue "19" @default.

• next