FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966626972> ?p ?o ?g. }

• W1966626972 endingPage "3267" @default.
• W1966626972 startingPage "3256" @default.
• W1966626972 abstract "The cancer/testis antigens (CTAs) are a group of heterogeneous proteins that are typically expressed in the testis but aberrantly expressed in several types of cancer. Although overexpression of CTAs is frequently associated with advanced disease and poorer prognosis, the significance of this correlation is unclear since the functions of the CTAs in the disease process remain poorly understood. Here, employing a bioinformatics approach, we show that a majority of CTAs are intrinsically disordered proteins (IDPs). IDPs are proteins that, under physiological conditions in vitro, lack rigid 3D structures either along their entire length or in localized regions. Despite the lack of structure, most IDPs can transition from disorder to order upon binding to biological targets and often promote highly promiscuous interactions. IDPs play important roles in transcriptional regulation and signaling via regulatory protein networks and are often associated with dosage sensitivity. Consistent with these observations, we find that several CTAs can bind DNA, and their forced expression appears to increase cell growth implying a potential dosage-sensitive function. Furthermore, the CTAs appear to occupy hub positions in protein regulatory networks that typically adopt a scale-free power law distribution. Taken together, our data provide a novel perspective on the CTAs implicating them in processing and transducing information in altered physiological states in a dosage-sensitive manner. Identifying the CTAs that occupy hub positions in protein regulatory networks would allow a better understanding of their functions as well as the development of novel therapeutics to treat cancer." @default.
• W1966626972 created "2016-06-24" @default.
• W1966626972 creator A5000390933 @default.
• W1966626972 creator A5020259891 @default.
• W1966626972 creator A5060055762 @default.
• W1966626972 creator A5064759824 @default.
• W1966626972 creator A5065110545 @default.
• W1966626972 date "2011-10-15" @default.
• W1966626972 modified "2023-10-15" @default.
• W1966626972 title "A majority of the cancer/testis antigens are intrinsically disordered proteins" @default.
• W1966626972 cites W1969765360 @default.
• W1966626972 cites W1975121208 @default.
• W1966626972 cites W1977943300 @default.
• W1966626972 cites W1981697014 @default.
• W1966626972 cites W2006285635 @default.
• W1966626972 cites W2008790235 @default.
• W1966626972 cites W2014748730 @default.
• W1966626972 cites W2015802360 @default.
• W1966626972 cites W2029093937 @default.
• W1966626972 cites W2038688261 @default.
• W1966626972 cites W2041025847 @default.
• W1966626972 cites W2043591644 @default.
• W1966626972 cites W2047750588 @default.
• W1966626972 cites W2050433648 @default.
• W1966626972 cites W2052929547 @default.
• W1966626972 cites W2053632669 @default.
• W1966626972 cites W2056943417 @default.
• W1966626972 cites W2076142854 @default.
• W1966626972 cites W2080857971 @default.
• W1966626972 cites W2088180120 @default.
• W1966626972 cites W2091218964 @default.
• W1966626972 cites W2096986143 @default.
• W1966626972 cites W2098357256 @default.
• W1966626972 cites W2099936062 @default.
• W1966626972 cites W2100814493 @default.
• W1966626972 cites W2101040530 @default.
• W1966626972 cites W2102025585 @default.
• W1966626972 cites W2102606027 @default.
• W1966626972 cites W2102701612 @default.
• W1966626972 cites W2104800372 @default.
• W1966626972 cites W2105545925 @default.
• W1966626972 cites W2106413110 @default.
• W1966626972 cites W2113039254 @default.
• W1966626972 cites W2113613985 @default.
• W1966626972 cites W2118608964 @default.
• W1966626972 cites W2119693327 @default.
• W1966626972 cites W2125262718 @default.
• W1966626972 cites W2130277691 @default.
• W1966626972 cites W2130790725 @default.
• W1966626972 cites W2131965976 @default.
• W1966626972 cites W2132720084 @default.
• W1966626972 cites W2133952653 @default.
• W1966626972 cites W2136669014 @default.
• W1966626972 cites W2138039051 @default.
• W1966626972 cites W2145786566 @default.
• W1966626972 cites W2153789013 @default.
• W1966626972 cites W2154335467 @default.
• W1966626972 cites W2156678798 @default.
• W1966626972 doi "https://doi.org/10.1002/jcb.23252" @default.
• W1966626972 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3214731" @default.
• W1966626972 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21748782" @default.
• W1966626972 hasPublicationYear "2011" @default.
• W1966626972 type Work @default.
• W1966626972 sameAs 1966626972 @default.
• W1966626972 citedByCount "140" @default.
• W1966626972 countsByYear W19666269722012 @default.
• W1966626972 countsByYear W19666269722013 @default.
• W1966626972 countsByYear W19666269722014 @default.
• W1966626972 countsByYear W19666269722015 @default.
• W1966626972 countsByYear W19666269722016 @default.
• W1966626972 countsByYear W19666269722017 @default.
• W1966626972 countsByYear W19666269722018 @default.
• W1966626972 countsByYear W19666269722019 @default.
• W1966626972 countsByYear W19666269722020 @default.
• W1966626972 countsByYear W19666269722021 @default.
• W1966626972 countsByYear W19666269722022 @default.
• W1966626972 countsByYear W19666269722023 @default.
• W1966626972 crossrefType "journal-article" @default.
• W1966626972 hasAuthorship W1966626972A5000390933 @default.
• W1966626972 hasAuthorship W1966626972A5020259891 @default.
• W1966626972 hasAuthorship W1966626972A5060055762 @default.
• W1966626972 hasAuthorship W1966626972A5064759824 @default.
• W1966626972 hasAuthorship W1966626972A5065110545 @default.
• W1966626972 hasBestOaLocation W19666269722 @default.
• W1966626972 hasConcept C121608353 @default.
• W1966626972 hasConcept C14036430 @default.
• W1966626972 hasConcept C2778815515 @default.
• W1966626972 hasConcept C54355233 @default.
• W1966626972 hasConcept C55493867 @default.
• W1966626972 hasConcept C70721500 @default.
• W1966626972 hasConcept C86803240 @default.
• W1966626972 hasConcept C95444343 @default.
• W1966626972 hasConceptScore W1966626972C121608353 @default.
• W1966626972 hasConceptScore W1966626972C14036430 @default.
• W1966626972 hasConceptScore W1966626972C2778815515 @default.
• W1966626972 hasConceptScore W1966626972C54355233 @default.
• W1966626972 hasConceptScore W1966626972C55493867 @default.
• W1966626972 hasConceptScore W1966626972C70721500 @default.

• next