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• W1966630440 abstract "RNA tertiary interactions or tertiary motifs are conserved structural patterns formed by pairwise interactions between nucleotides. They include base-pairing, base-stacking, and base-phosphate interactions. A-minor motifs are the most common tertiary interactions in the large ribosomal subunit. The A-minor motif is a nucleotide triple in which minor groove edges of an adenine base are inserted into the minor groove of neighboring helices, leading to interaction with a stabilizing base pair. We propose here novel features for identifying and predicting A-minor motifs in a given three-dimensional RNA molecule. By utilizing the features together with machine learning algorithms including random forests and support vector machines, we show experimentally that our approach is capable of predicting A-minor motifs in the given RNA molecule effectively, demonstrating the usefulness of the proposed approach. The techniques developed from this work will be useful for molecular biologists and biochemists to analyze RNA tertiary motifs, specifically A-minor interactions." @default.
• W1966630440 created "2016-06-24" @default.
• W1966630440 creator A5028295252 @default.
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• W1966630440 date "2013-12-01" @default.
• W1966630440 modified "2023-09-24" @default.
• W1966630440 title "Novel features for identifying A-minors in three-dimensional RNA molecules" @default.
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• W1966630440 doi "https://doi.org/10.1016/j.compbiolchem.2013.10.004" @default.
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• W1966630440 hasPublicationYear "2013" @default.
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