FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966634530> ?p ?o ?g. }

• W1966634530 endingPage "459" @default.
• W1966634530 startingPage "447" @default.
• W1966634530 abstract "We have previously reported the synthesis and characterization of two new classes of selenazolidine-4(R)-carboxylic acids (2-oxo and 2-methyl-SCAs) (OSCA and MSCA, respectively), as well as the parent compound, selenazolidine-4(R)-carboxylic acid (SCA, selenaproline). These compounds were designed as prodrugs of L-selenocysteine with potential application in cancer chemoprevention or other clinical uses. We will be exploring the chemopreventive activity of the new compounds in the well-established A/J mouse model of tobacco-induced lung carcinogenesis. The objectives of the present study were to investigate several fundamental biochemical endpoints after selenazolidine administration compared with other selenium-containing agents. Groups of mice were fed either AIN-76A diet alone or the diet supplemented with the following selenium compounds (ppm Se): sodium selenite (5), L-selenomethionine (3.75), L-selenocystine (15), Se-methyl-L-selenocysteine (3), MSCA (5, 10, or 15), OSCA (5, 10, or 15), or SCA (5, 10, or 15). After 28 days of supplementation, toxicity of the selenazolidines was not evident, as measured by outward appearance and behavior, body and organ weight changes, and histological evaluation of liver and lung tissue. Select treatment groups showed significant increases in selenium levels in blood and tissues. Increased activity of selenium-dependent glutathione peroxidase (GPx) in blood and liver illustrated that the selenazolidines provided a source of biologically-available selenium." @default.
• W1966634530 created "2016-06-24" @default.
• W1966634530 creator A5006945103 @default.
• W1966634530 creator A5064564309 @default.
• W1966634530 creator A5068497709 @default.
• W1966634530 creator A5072638212 @default.
• W1966634530 creator A5088167860 @default.
• W1966634530 date "2004-06-01" @default.
• W1966634530 modified "2023-10-05" @default.
• W1966634530 title "Characteristics of selenazolidine prodrugs of selenocysteine: toxicity, selenium levels, and glutathione peroxidase induction in A/J mice" @default.
• W1966634530 cites W1535793768 @default.
• W1966634530 cites W1550873995 @default.
• W1966634530 cites W1670156051 @default.
• W1966634530 cites W1758507682 @default.
• W1966634530 cites W1886258150 @default.
• W1966634530 cites W1904486154 @default.
• W1966634530 cites W1968512875 @default.
• W1966634530 cites W1969881152 @default.
• W1966634530 cites W1972521636 @default.
• W1966634530 cites W1976381141 @default.
• W1966634530 cites W1980696694 @default.
• W1966634530 cites W1987338970 @default.
• W1966634530 cites W2008109764 @default.
• W1966634530 cites W2010930508 @default.
• W1966634530 cites W2010974779 @default.
• W1966634530 cites W2012077757 @default.
• W1966634530 cites W2018330970 @default.
• W1966634530 cites W2037412322 @default.
• W1966634530 cites W2055426944 @default.
• W1966634530 cites W2057168974 @default.
• W1966634530 cites W2065371516 @default.
• W1966634530 cites W2067358204 @default.
• W1966634530 cites W2070611230 @default.
• W1966634530 cites W2077219185 @default.
• W1966634530 cites W2085039235 @default.
• W1966634530 cites W2091117378 @default.
• W1966634530 cites W2160508961 @default.
• W1966634530 cites W2161427454 @default.
• W1966634530 cites W2175532913 @default.
• W1966634530 cites W2329163451 @default.
• W1966634530 cites W2330859524 @default.
• W1966634530 cites W2434126822 @default.
• W1966634530 cites W4245684785 @default.
• W1966634530 cites W4251440173 @default.
• W1966634530 doi "https://doi.org/10.1016/j.lfs.2003.12.018" @default.
• W1966634530 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15147831" @default.
• W1966634530 hasPublicationYear "2004" @default.
• W1966634530 type Work @default.
• W1966634530 sameAs 1966634530 @default.
• W1966634530 citedByCount "22" @default.
• W1966634530 countsByYear W19666345302012 @default.
• W1966634530 countsByYear W19666345302014 @default.
• W1966634530 countsByYear W19666345302015 @default.
• W1966634530 countsByYear W19666345302019 @default.
• W1966634530 countsByYear W19666345302022 @default.
• W1966634530 countsByYear W19666345302023 @default.
• W1966634530 crossrefType "journal-article" @default.
• W1966634530 hasAuthorship W1966634530A5006945103 @default.
• W1966634530 hasAuthorship W1966634530A5064564309 @default.
• W1966634530 hasAuthorship W1966634530A5068497709 @default.
• W1966634530 hasAuthorship W1966634530A5072638212 @default.
• W1966634530 hasAuthorship W1966634530A5088167860 @default.
• W1966634530 hasConcept C104317684 @default.
• W1966634530 hasConcept C108215921 @default.
• W1966634530 hasConcept C114246631 @default.
• W1966634530 hasConcept C162008176 @default.
• W1966634530 hasConcept C178790620 @default.
• W1966634530 hasConcept C181199279 @default.
• W1966634530 hasConcept C185592680 @default.
• W1966634530 hasConcept C2776087148 @default.
• W1966634530 hasConcept C2778760513 @default.
• W1966634530 hasConcept C2779201268 @default.
• W1966634530 hasConcept C29730261 @default.
• W1966634530 hasConcept C538909803 @default.
• W1966634530 hasConcept C553756173 @default.
• W1966634530 hasConcept C55493867 @default.
• W1966634530 hasConcept C555283112 @default.
• W1966634530 hasConcept C86803240 @default.
• W1966634530 hasConcept C98274493 @default.
• W1966634530 hasConceptScore W1966634530C104317684 @default.
• W1966634530 hasConceptScore W1966634530C108215921 @default.
• W1966634530 hasConceptScore W1966634530C114246631 @default.
• W1966634530 hasConceptScore W1966634530C162008176 @default.
• W1966634530 hasConceptScore W1966634530C178790620 @default.
• W1966634530 hasConceptScore W1966634530C181199279 @default.
• W1966634530 hasConceptScore W1966634530C185592680 @default.
• W1966634530 hasConceptScore W1966634530C2776087148 @default.
• W1966634530 hasConceptScore W1966634530C2778760513 @default.
• W1966634530 hasConceptScore W1966634530C2779201268 @default.
• W1966634530 hasConceptScore W1966634530C29730261 @default.
• W1966634530 hasConceptScore W1966634530C538909803 @default.
• W1966634530 hasConceptScore W1966634530C553756173 @default.
• W1966634530 hasConceptScore W1966634530C55493867 @default.
• W1966634530 hasConceptScore W1966634530C555283112 @default.
• W1966634530 hasConceptScore W1966634530C86803240 @default.
• W1966634530 hasConceptScore W1966634530C98274493 @default.
• W1966634530 hasIssue "4" @default.
• W1966634530 hasLocation W19666345301 @default.

• next