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• W1966641521 abstract "Alpha 1-Adrenergic-stimulated calcium efflux from rat parotid cell aggregates declines approx. 40% between 3 and 24 months of age, with the bulk of the reduction occurring between 12 and 24 months. Intracellular free calcium levels following alpha 1-adrenoceptor stimulation are also reduced about 40% between 3 and 24 months. No significant age differences in stimulation of inositol mono-, bis- or trisphosphate production are observed. However, the ability of inositol trisphosphate to directly stimulate calcium efflux is reduced by about 50% with increasing age. Concentrations of this inositol phosphate required for maximal calcium release do not change between 3 and 24 months. Differences in response are not due to a reduction in uptake of inositol trisphosphate into older cells, but suggest an age-related defect in the ability of inositol trisphosphate to liberate calcium from intracellular stores. Such dysfunction may be at least partially responsible for impaired alpha 1-adrenergic responsiveness during aging." @default.
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• W1966641521 date "1988-02-01" @default.
• W1966641521 modified "2023-09-27" @default.
• W1966641521 title "Age-related impairment in rat parotid cell α1-adrenergic action at the level of inositol trisphosphate responsiveness" @default.
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• W1966641521 doi "https://doi.org/10.1016/0167-4889(88)90009-2" @default.
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