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• W1966641821 abstract "Acute intermittent porphyria (AIP) is the most common type of hepatic acute porphyria. In this work, we have analyzed the biochemical data of all Argentinean AIP families studied in the Porphyrins and Porphyrias Research Centre (CIPYP). We have shown that: (i) the prevalence for this population is about 1:125,000; (ii) the disease is more frequent in women than in men (7:3); (iii) about 60% are latent carriers; (iv) 15% of patients with symptomatic AIP died during an acute attack; (v) the most important precipitating factors of acute attacks in our population were the ingestion of therapeutic drugs (25%), anesthetics in surgical interventions (25%) and infections (20%); (vi) the initial symptom in Argentinean AIP individuals is severe abdominal pain (100%), and it is often accompanied by constipation (37%), anorexia (37%) and tachycardia (30%); and (vii) the percentage of recurrence of the acute attacks is high (81%)." @default.
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• W1966641821 date "1999-10-01" @default.
• W1966641821 modified "2023-10-16" @default.
• W1966641821 title "Acute intermittent porphyria: Biochemical and clinical analysis in the Argentinean population" @default.
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• W1966641821 doi "https://doi.org/10.1016/s0009-8981(99)00139-4" @default.
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