Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966643076> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W1966643076 abstract "Skin has various types of transporters and is a biochemically active organ. These aspects of skin influence the distribution of chemicals in skin and their elimination from skin. The biochemical and histological variations of the skin must be taken into account when conducting transdermal penetration research. Here we used hairless mouse skin to investigate the percutaneous absorption of chemicals in vitro from the stratum corneum (SC) side to the viable skin (VS) side (forward direction) and from the VS side to the SC side (backward direction). We examined the effects of molecular weight, lipophilicity (Log Ko/w), electric charge, and the molecular structure of penetrants. The penetration flux of verapamil hydrochloride (VRP) for the backward direction was 3.2 times larger than that for the forward direction. The flux values of benzoic acid (BA) and para-hydroxybenzoic acid (pHBA) for the forward direction were 2.1 and 4.6 times larger than those for the backward direction, respectively. This directional difference was caused by the active transporter for VRP, the histological distribution of BA solubility, and the intermolecular hydrogen bonding between pHBA and skin tissue in the stripped skin. Across intact skin, in contrast, there was no difference in the skin penetration profile between the forward direction and backward directions." @default.
- W1966643076 created "2016-06-24" @default.
- W1966643076 creator A5044201238 @default.
- W1966643076 creator A5049000257 @default.
- W1966643076 creator A5068305682 @default.
- W1966643076 date "2013-01-01" @default.
- W1966643076 modified "2023-10-03" @default.
- W1966643076 title "Effect of Diffusive Direction across the Skin on the Penetration Profile of Chemicals <i>in Vitro</i>" @default.
- W1966643076 cites W124097478 @default.
- W1966643076 cites W1971181330 @default.
- W1966643076 cites W1974280162 @default.
- W1966643076 cites W1976143560 @default.
- W1966643076 cites W1980146396 @default.
- W1966643076 cites W1994595799 @default.
- W1966643076 cites W2010216121 @default.
- W1966643076 cites W2016955174 @default.
- W1966643076 cites W2047830434 @default.
- W1966643076 cites W2070380377 @default.
- W1966643076 cites W2076260569 @default.
- W1966643076 cites W2076533733 @default.
- W1966643076 cites W2086343111 @default.
- W1966643076 cites W2150077374 @default.
- W1966643076 cites W2152548356 @default.
- W1966643076 doi "https://doi.org/10.1248/bpb.b13-00331" @default.
- W1966643076 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24189420" @default.
- W1966643076 hasPublicationYear "2013" @default.
- W1966643076 type Work @default.
- W1966643076 sameAs 1966643076 @default.
- W1966643076 citedByCount "2" @default.
- W1966643076 countsByYear W19666430762015 @default.
- W1966643076 countsByYear W19666430762020 @default.
- W1966643076 crossrefType "journal-article" @default.
- W1966643076 hasAuthorship W1966643076A5044201238 @default.
- W1966643076 hasAuthorship W1966643076A5049000257 @default.
- W1966643076 hasAuthorship W1966643076A5068305682 @default.
- W1966643076 hasBestOaLocation W19666430761 @default.
- W1966643076 hasConcept C12554922 @default.
- W1966643076 hasConcept C127413603 @default.
- W1966643076 hasConcept C155574463 @default.
- W1966643076 hasConcept C178790620 @default.
- W1966643076 hasConcept C185592680 @default.
- W1966643076 hasConcept C201399114 @default.
- W1966643076 hasConcept C205679159 @default.
- W1966643076 hasConcept C2777459323 @default.
- W1966643076 hasConcept C2778370115 @default.
- W1966643076 hasConcept C2779156968 @default.
- W1966643076 hasConcept C41625074 @default.
- W1966643076 hasConcept C42475967 @default.
- W1966643076 hasConcept C50670333 @default.
- W1966643076 hasConcept C54355233 @default.
- W1966643076 hasConcept C55493867 @default.
- W1966643076 hasConcept C71240020 @default.
- W1966643076 hasConcept C80107235 @default.
- W1966643076 hasConcept C86803240 @default.
- W1966643076 hasConcept C98274493 @default.
- W1966643076 hasConceptScore W1966643076C12554922 @default.
- W1966643076 hasConceptScore W1966643076C127413603 @default.
- W1966643076 hasConceptScore W1966643076C155574463 @default.
- W1966643076 hasConceptScore W1966643076C178790620 @default.
- W1966643076 hasConceptScore W1966643076C185592680 @default.
- W1966643076 hasConceptScore W1966643076C201399114 @default.
- W1966643076 hasConceptScore W1966643076C205679159 @default.
- W1966643076 hasConceptScore W1966643076C2777459323 @default.
- W1966643076 hasConceptScore W1966643076C2778370115 @default.
- W1966643076 hasConceptScore W1966643076C2779156968 @default.
- W1966643076 hasConceptScore W1966643076C41625074 @default.
- W1966643076 hasConceptScore W1966643076C42475967 @default.
- W1966643076 hasConceptScore W1966643076C50670333 @default.
- W1966643076 hasConceptScore W1966643076C54355233 @default.
- W1966643076 hasConceptScore W1966643076C55493867 @default.
- W1966643076 hasConceptScore W1966643076C71240020 @default.
- W1966643076 hasConceptScore W1966643076C80107235 @default.
- W1966643076 hasConceptScore W1966643076C86803240 @default.
- W1966643076 hasConceptScore W1966643076C98274493 @default.
- W1966643076 hasLocation W19666430761 @default.
- W1966643076 hasLocation W19666430762 @default.
- W1966643076 hasOpenAccess W1966643076 @default.
- W1966643076 hasPrimaryLocation W19666430761 @default.
- W1966643076 hasRelatedWork W1965380106 @default.
- W1966643076 hasRelatedWork W1989261448 @default.
- W1966643076 hasRelatedWork W1996814703 @default.
- W1966643076 hasRelatedWork W2002191209 @default.
- W1966643076 hasRelatedWork W2088732840 @default.
- W1966643076 hasRelatedWork W2091831115 @default.
- W1966643076 hasRelatedWork W2102067160 @default.
- W1966643076 hasRelatedWork W3124821085 @default.
- W1966643076 hasRelatedWork W800976114 @default.
- W1966643076 hasRelatedWork W199828531 @default.
- W1966643076 isParatext "false" @default.
- W1966643076 isRetracted "false" @default.
- W1966643076 magId "1966643076" @default.
- W1966643076 workType "article" @default.