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• W1966644966 abstract "Evolutionary molecular design based on genetic algorithms (GAs) has been demonstrated to be a flexible and efficient optimization approach with potential for locating global optima. Its efficacy and efficiency are largely dependent on the operations and control parameters of the GAs. Accordingly, we have explored new operations and probed good parameter setting through simulations. The findings have been evaluated in a helical peptide design according to Parameter setting by analogy strategy; highly helical peptides have been successfully obtained with a population of only 16 peptides and 5 iterative cycles. The results indicate that new operations such as multi-step crossover-mutation are able to improve the explorative efficiency and to reduce the sensitivity to crossover and mutation rates (CR-MR). The efficiency of the peptide design has been furthermore improved by setting the GAs at the good CR-MR setting determined through simulation. These results suggest that probing the operations and parameter settings through simulation in combination with Parameter setting by analogy strategy provides an effective framework for improving the efficiency of the approach. Consequently, we conclude that this framework will be useful for contributing to practical peptide design, and gaining a better understanding of evolutionary molecular design." @default.
• W1966644966 created "2016-06-24" @default.
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• W1966644966 date "2007-03-01" @default.
• W1966644966 modified "2023-09-30" @default.
• W1966644966 title "Improving the efficiency of evolutionary de novo peptide design: Strategies for probing configuration and parameter settings" @default.
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• W1966644966 doi "https://doi.org/10.1016/j.biosystems.2006.04.007" @default.
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