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- W1966653882 abstract "The inappropriate use of combinations of estrogen and progestagens to prevent miscarriages for pregnancy testing and for other complications of pregnancy is discussed. Physicians have continued to prescribe these drugs despite evidence that they may produce birth defects. It has been shown that the incidence of birth defects among women taking these drugs is 2-5 times higher than those who are untreated. In light of the preliminary evidence the Food and Drug Administration withdrew approval of the drugs for use during pregnancy. Early in 1975 a bulletin was mailed to physicians and other health professionals further warning them against the use of the drugs. However evidence obtained by the International Marketing Service of Ambler Pennsylvania indicates that in 1975 physicians wrote only about 10% less prescriptions for these drugs than when they were approved in 1972. Further regulations are being prepared concerning the hormones. Manufacturers will also be required to revise physician labeling for the hormones to incorporate a warning against use in early pregnancy." @default.
- W1966653882 created "2016-06-24" @default.
- W1966653882 creator A5068721337 @default.
- W1966653882 date "1976-11-26" @default.
- W1966653882 modified "2023-09-27" @default.
- W1966653882 title "Irrational Drug Prescribing and Birth Defects" @default.
- W1966653882 doi "https://doi.org/10.1126/science.194.4268.926" @default.
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