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- W1966654803 abstract "The influence of ionization states of hydroxamates and retrohydroxamates and the presence of zinc ions in the active site were investigated using the wild-type and E402Q mutant of MMP-9. The deprotonated hydroxamates showed a significantly enhanced enrichment factor in the presence of zinc ions. A pharmacophore model was developed based on the deprotonated compounds and was used to identify four structurally diverse compounds with antiproliferative activities." @default.
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- W1966654803 date "2011-04-07" @default.
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- W1966654803 title "The Impact of Ionization States of Matrix Metalloproteinase Inhibitors on Docking-Based Inhibitor Design" @default.
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- W1966654803 doi "https://doi.org/10.1021/ml200031m" @default.
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