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- W1966659377 abstract "1 Respiratory and cardiovascular failure are the princi ple toxic effects of β-blocker overdose. Respiratory arrest is the primary cause of death in β-blocker intoxicated rats. 2 The effect of glucagon, dopamine and the combination of glucagon/dopamine on respiratory and cardiovas cular function and survival time in β-blocker overdose was investigated in a model of acute d, l-propranolol (resp. 30 and 15 mg kg -1 h -1 in rat and rabbit) intoxication in spontaneously breathing rats and artifically ventilated rats and rabbits. 3 Glucagon (initial dose of 100 μg kg -1 (bolus), followed by 1 μg kg -1 min -1 ), dopamine (25 μg kg -1 min -1 ) or the combination of glucagon/dopamine did not im prove survival time (ST) in d, l-propranolol intoxicated spontaneously breathing rats and artificially venti lated rats and rabbits, although some haemodynamic variables i.e. heart rate (HR), mean arterial blood pressure (MAP), left ventricular pressure (LVP max ) and the differentiated left ventricular pressure (LVdp/ dt max ) temporarily improved. 4 Survival time was considerably reduced in d,l- propranolol intoxicated spontaneously breathing and artifically ventilated rats treated with a combination of glucagon /dopamine, which induced a decrease in PaO 2 and pH and an increase in PaCO 2 partly due to ventilation/perfusion mismatch. 5 The combination of glucagon/dopamine should be used carefully in the treatment of β-blocker overdose in man." @default.
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- W1966659377 date "1996-05-01" @default.
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- W1966659377 title "Experimental study of the detrimental effect of dopamine/glucagon combination in d,l- propranolol intoxication" @default.
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- W1966659377 doi "https://doi.org/10.1177/096032719601500509" @default.
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