FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966664168> ?p ?o ?g. }

• W1966664168 endingPage "3878" @default.
• W1966664168 startingPage "3873" @default.
• W1966664168 abstract "The CD4 gene is regulated in a stage-specific manner during T cell development, being repressed in CD4 − CD8 − double-negative (DN) and CD8 cells, but expressed in CD4 + CD8 + double-positive (DP) and CD4 cells. Furthermore, the expression/repression pattern is reversible in developing (DN and DP) thymocytes, but irreversible in mature (CD4 and CD8) T cells. Here, we explored the molecular mechanisms underlying this complex mode of regulation by examining the nucleoprotein structure of the CD4 locus throughout T cell development and in DN cells lacking the CD4 silencer. In DN cells, the CD4 enhancer is preloaded with multiple transcription activators, but p300 recruitment is impaired by the silencer that is associated with the repressor Runx1. DP cells achieve high-level CD4 expression via a combination of CD4 derepression and true activation, but Runx1 remains bound to the silencer that retains an open chromatin configuration. In CD4 cells, Runx1 dissociates from the silencer that has become less accessible, and CD4 transcription appears to be achieved via a mechanism distinct from that operating in DP cells. In CD8 cells, the CD4 promoter becomes incorporated into heterochromatin-like structure. Our data shed light on the molecular basis of CD4 regulation and provide a conceptual framework for understanding how the same regulatory elements can mediate both reversible and irreversible CD4 regulation." @default.
• W1966664168 created "2016-06-24" @default.
• W1966664168 creator A5014709585 @default.
• W1966664168 creator A5027345550 @default.
• W1966664168 creator A5036911243 @default.
• W1966664168 creator A5052479360 @default.
• W1966664168 creator A5079156452 @default.
• W1966664168 creator A5084714753 @default.
• W1966664168 date "2008-03-11" @default.
• W1966664168 modified "2023-10-16" @default.
• W1966664168 title "Nucleoprotein structure of the CD4 locus: Implications for the mechanisms underlying CD4 regulation during T cell development" @default.
• W1966664168 cites W1479718839 @default.
• W1966664168 cites W1529305202 @default.
• W1966664168 cites W1563213132 @default.
• W1966664168 cites W1583982882 @default.
• W1966664168 cites W1647052252 @default.
• W1966664168 cites W1658849455 @default.
• W1966664168 cites W1829983658 @default.
• W1966664168 cites W1954748479 @default.
• W1966664168 cites W1963506471 @default.
• W1966664168 cites W1979812167 @default.
• W1966664168 cites W1981640600 @default.
• W1966664168 cites W1987687886 @default.
• W1966664168 cites W1989718881 @default.
• W1966664168 cites W1992230801 @default.
• W1966664168 cites W2013146483 @default.
• W1966664168 cites W2017702380 @default.
• W1966664168 cites W2019911194 @default.
• W1966664168 cites W2022756254 @default.
• W1966664168 cites W2035634881 @default.
• W1966664168 cites W2036498443 @default.
• W1966664168 cites W2037027093 @default.
• W1966664168 cites W2047500542 @default.
• W1966664168 cites W2051283527 @default.
• W1966664168 cites W2064625809 @default.
• W1966664168 cites W2072665920 @default.
• W1966664168 cites W2084051071 @default.
• W1966664168 cites W2085265750 @default.
• W1966664168 cites W2091558866 @default.
• W1966664168 cites W2115419666 @default.
• W1966664168 cites W2117356113 @default.
• W1966664168 cites W2142162924 @default.
• W1966664168 cites W2143713452 @default.
• W1966664168 cites W2162928535 @default.
• W1966664168 cites W2163331909 @default.
• W1966664168 cites W332620341 @default.
• W1966664168 cites W4239993434 @default.
• W1966664168 doi "https://doi.org/10.1073/pnas.0800810105" @default.
• W1966664168 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2268827" @default.
• W1966664168 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18322012" @default.
• W1966664168 hasPublicationYear "2008" @default.
• W1966664168 type Work @default.
• W1966664168 sameAs 1966664168 @default.
• W1966664168 citedByCount "32" @default.
• W1966664168 countsByYear W19666641682012 @default.
• W1966664168 countsByYear W19666641682013 @default.
• W1966664168 countsByYear W19666641682014 @default.
• W1966664168 countsByYear W19666641682015 @default.
• W1966664168 countsByYear W19666641682016 @default.
• W1966664168 countsByYear W19666641682017 @default.
• W1966664168 countsByYear W19666641682018 @default.
• W1966664168 countsByYear W19666641682019 @default.
• W1966664168 crossrefType "journal-article" @default.
• W1966664168 hasAuthorship W1966664168A5014709585 @default.
• W1966664168 hasAuthorship W1966664168A5027345550 @default.
• W1966664168 hasAuthorship W1966664168A5036911243 @default.
• W1966664168 hasAuthorship W1966664168A5052479360 @default.
• W1966664168 hasAuthorship W1966664168A5079156452 @default.
• W1966664168 hasAuthorship W1966664168A5084714753 @default.
• W1966664168 hasBestOaLocation W19666641681 @default.
• W1966664168 hasConcept C104317684 @default.
• W1966664168 hasConcept C111936080 @default.
• W1966664168 hasConcept C127413603 @default.
• W1966664168 hasConcept C147483822 @default.
• W1966664168 hasConcept C150194340 @default.
• W1966664168 hasConcept C153911025 @default.
• W1966664168 hasConcept C158448853 @default.
• W1966664168 hasConcept C167672396 @default.
• W1966664168 hasConcept C186310378 @default.
• W1966664168 hasConcept C190414344 @default.
• W1966664168 hasConcept C201289731 @default.
• W1966664168 hasConcept C54355233 @default.
• W1966664168 hasConcept C73766848 @default.
• W1966664168 hasConcept C78519656 @default.
• W1966664168 hasConcept C83640560 @default.
• W1966664168 hasConcept C86339819 @default.
• W1966664168 hasConcept C86803240 @default.
• W1966664168 hasConcept C95444343 @default.
• W1966664168 hasConceptScore W1966664168C104317684 @default.
• W1966664168 hasConceptScore W1966664168C111936080 @default.
• W1966664168 hasConceptScore W1966664168C127413603 @default.
• W1966664168 hasConceptScore W1966664168C147483822 @default.
• W1966664168 hasConceptScore W1966664168C150194340 @default.
• W1966664168 hasConceptScore W1966664168C153911025 @default.
• W1966664168 hasConceptScore W1966664168C158448853 @default.
• W1966664168 hasConceptScore W1966664168C167672396 @default.
• W1966664168 hasConceptScore W1966664168C186310378 @default.
• W1966664168 hasConceptScore W1966664168C190414344 @default.

• next