FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966679178> ?p ?o ?g. }

• W1966679178 endingPage "1041" @default.
• W1966679178 startingPage "1025" @default.
• W1966679178 abstract "Variations in K(+) channel composition allow for differences in cell excitability and, at an organismal level, provide flexibility to behavioral regulation. When the function of a K(+) channel is disrupted, the remaining K(+) channels might incompletely compensate, manifesting as abnormal organismal behavior. In this study, we explored how different K(+) channels interact to regulate the neuromuscular circuitry used by Caenorhabditis elegans males to protract their copulatory spicules from their tail and insert them into the hermaphrodite's vulva during mating. We determined that the big current K(+) channel (BK)/SLO-1 genetically interacts with ether-a-go-go (EAG)/EGL-2 and EAG-related gene/UNC-103 K(+) channels to control spicule protraction. Through rescue experiments, we show that specific slo-1 isoforms affect spicule protraction. Gene expression studies show that slo-1 and egl-2 expression can be upregulated in a calcium/calmodulin-dependent protein kinase II-dependent manner to compensate for the loss of unc-103 and conversely, unc-103 can partially compensate for the loss of SLO-1 function. In conclusion, an interaction between BK and EAG family K(+) channels produces the muscle excitability levels that regulate the timing of spicule protraction and the success of male mating behavior." @default.
• W1966679178 created "2016-06-24" @default.
• W1966679178 creator A5064139321 @default.
• W1966679178 creator A5066493648 @default.
• W1966679178 date "2012-03-01" @default.
• W1966679178 modified "2023-10-16" @default.
• W1966679178 title "Cell Excitability Necessary for Male Mating Behavior in <i>Caenorhabditis elegans</i> Is Coordinated by Interactions Between Big Current and Ether-A-Go-Go Family K+ Channels" @default.
• W1966679178 cites W1526576192 @default.
• W1966679178 cites W1592163034 @default.
• W1966679178 cites W1611469980 @default.
• W1966679178 cites W1630027754 @default.
• W1966679178 cites W1762858688 @default.
• W1966679178 cites W1941436081 @default.
• W1966679178 cites W1944127002 @default.
• W1966679178 cites W1948560580 @default.
• W1966679178 cites W1954391111 @default.
• W1966679178 cites W1956158614 @default.
• W1966679178 cites W1966751687 @default.
• W1966679178 cites W1968098810 @default.
• W1966679178 cites W1969042688 @default.
• W1966679178 cites W1976769006 @default.
• W1966679178 cites W1979772434 @default.
• W1966679178 cites W1989952069 @default.
• W1966679178 cites W1996051526 @default.
• W1966679178 cites W1996280803 @default.
• W1966679178 cites W2001920462 @default.
• W1966679178 cites W2007372862 @default.
• W1966679178 cites W2007860569 @default.
• W1966679178 cites W2020093064 @default.
• W1966679178 cites W2021775978 @default.
• W1966679178 cites W2024039709 @default.
• W1966679178 cites W2030155143 @default.
• W1966679178 cites W2034566067 @default.
• W1966679178 cites W2035089560 @default.
• W1966679178 cites W2039916525 @default.
• W1966679178 cites W2041959419 @default.
• W1966679178 cites W2049227829 @default.
• W1966679178 cites W2050155052 @default.
• W1966679178 cites W2053708573 @default.
• W1966679178 cites W2056056975 @default.
• W1966679178 cites W2065624887 @default.
• W1966679178 cites W2071823339 @default.
• W1966679178 cites W2071960125 @default.
• W1966679178 cites W2076645585 @default.
• W1966679178 cites W2079441999 @default.
• W1966679178 cites W2080990756 @default.
• W1966679178 cites W2084443378 @default.
• W1966679178 cites W2085534162 @default.
• W1966679178 cites W2087491465 @default.
• W1966679178 cites W2089157424 @default.
• W1966679178 cites W2091775798 @default.
• W1966679178 cites W2092528278 @default.
• W1966679178 cites W2092789015 @default.
• W1966679178 cites W2094316798 @default.
• W1966679178 cites W2094730070 @default.
• W1966679178 cites W2095180289 @default.
• W1966679178 cites W2102161874 @default.
• W1966679178 cites W2105639431 @default.
• W1966679178 cites W2107277218 @default.
• W1966679178 cites W2107587237 @default.
• W1966679178 cites W2109924563 @default.
• W1966679178 cites W2113111385 @default.
• W1966679178 cites W2115676911 @default.
• W1966679178 cites W2116934212 @default.
• W1966679178 cites W2119866964 @default.
• W1966679178 cites W2122163057 @default.
• W1966679178 cites W2124938115 @default.
• W1966679178 cites W2127983813 @default.
• W1966679178 cites W2130973560 @default.
• W1966679178 cites W2134176105 @default.
• W1966679178 cites W2135460924 @default.
• W1966679178 cites W2144630422 @default.
• W1966679178 cites W2144830324 @default.
• W1966679178 cites W2157166663 @default.
• W1966679178 cites W2161488670 @default.
• W1966679178 cites W2163801823 @default.
• W1966679178 cites W2164804804 @default.
• W1966679178 cites W2165665416 @default.
• W1966679178 cites W2172264769 @default.
• W1966679178 cites W2187190795 @default.
• W1966679178 doi "https://doi.org/10.1534/genetics.111.137455" @default.
• W1966679178 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3296240" @default.
• W1966679178 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22174070" @default.
• W1966679178 hasPublicationYear "2012" @default.
• W1966679178 type Work @default.
• W1966679178 sameAs 1966679178 @default.
• W1966679178 citedByCount "18" @default.
• W1966679178 countsByYear W19666791782013 @default.
• W1966679178 countsByYear W19666791782014 @default.
• W1966679178 countsByYear W19666791782015 @default.
• W1966679178 countsByYear W19666791782016 @default.
• W1966679178 countsByYear W19666791782017 @default.
• W1966679178 countsByYear W19666791782018 @default.
• W1966679178 countsByYear W19666791782021 @default.
• W1966679178 countsByYear W19666791782022 @default.
• W1966679178 crossrefType "journal-article" @default.
• W1966679178 hasAuthorship W1966679178A5064139321 @default.
• W1966679178 hasAuthorship W1966679178A5066493648 @default.

• next