Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966682037> ?p ?o ?g. }
- W1966682037 endingPage "1616" @default.
- W1966682037 startingPage "1610" @default.
- W1966682037 abstract "Cancer is the second-leading cause of death in the U.S. behind heart disease and over stroke. The hallmarks of cancer comprise six biological capabilities acquired during the multistep development of human tumors. The inhibition of cell death pathways is one of these tumor characteristics which also include sustained proliferative signaling, evading growth suppressor signaling, replicative immortality, angiogenesis, and promotion of invasion and metastasis. Cell death is mediated through death receptor (DR) stimulation initiated by specific ligands that transmit signaling to the cell death machinery or through the participation of mitochondria. Cell death involving DR is mediated by the superfamily of tumor necrosis factor receptor (TNF-R) which includes TNF-R type I, CD95, DR3, TNF-related apoptosis-inducing ligand (TRAIL) receptor-1 (TRAIL-R1) and -2 (TRAIL-R2), DR6, ectodysplasin A (EDA) receptor (EDAR), and the nerve growth factor (NGF) receptor (NGFR). The expression of these receptors in healthy and tumor cells induces treatment side effects that limit the systemic administration of cell death-inducing therapies. The present review is focused on the different therapeutic strategies such as targeted antibodies or small molecules addressed to selective stimulated DR-mediated apoptosis or reduce cell proliferation in cancer cells." @default.
- W1966682037 created "2016-06-24" @default.
- W1966682037 creator A5050640639 @default.
- W1966682037 date "2011-07-21" @default.
- W1966682037 modified "2023-10-17" @default.
- W1966682037 title "Harnessing Tumor Necrosis Factor Receptors to Enhance Antitumor Activities of Drugs" @default.
- W1966682037 cites W1481925502 @default.
- W1966682037 cites W1578307296 @default.
- W1966682037 cites W1828812390 @default.
- W1966682037 cites W1964215887 @default.
- W1966682037 cites W1966347912 @default.
- W1966682037 cites W1967336797 @default.
- W1966682037 cites W1967894078 @default.
- W1966682037 cites W1967928952 @default.
- W1966682037 cites W1969771851 @default.
- W1966682037 cites W1969791237 @default.
- W1966682037 cites W1969893319 @default.
- W1966682037 cites W1970042958 @default.
- W1966682037 cites W1975937960 @default.
- W1966682037 cites W1977499961 @default.
- W1966682037 cites W1978824927 @default.
- W1966682037 cites W1979914746 @default.
- W1966682037 cites W1980134172 @default.
- W1966682037 cites W1987506447 @default.
- W1966682037 cites W1989864703 @default.
- W1966682037 cites W1991875104 @default.
- W1966682037 cites W1994266361 @default.
- W1966682037 cites W1995673543 @default.
- W1966682037 cites W1995871393 @default.
- W1966682037 cites W1997106678 @default.
- W1966682037 cites W1997288872 @default.
- W1966682037 cites W1997759940 @default.
- W1966682037 cites W1999141617 @default.
- W1966682037 cites W1999587785 @default.
- W1966682037 cites W2000368283 @default.
- W1966682037 cites W2001270076 @default.
- W1966682037 cites W2002318323 @default.
- W1966682037 cites W2002702098 @default.
- W1966682037 cites W2004350020 @default.
- W1966682037 cites W2004457956 @default.
- W1966682037 cites W2007007348 @default.
- W1966682037 cites W2009085926 @default.
- W1966682037 cites W2012041771 @default.
- W1966682037 cites W2015907913 @default.
- W1966682037 cites W2017728303 @default.
- W1966682037 cites W2019409985 @default.
- W1966682037 cites W2020600328 @default.
- W1966682037 cites W2025128734 @default.
- W1966682037 cites W2030631359 @default.
- W1966682037 cites W2032560191 @default.
- W1966682037 cites W2034895966 @default.
- W1966682037 cites W2036009804 @default.
- W1966682037 cites W2042245678 @default.
- W1966682037 cites W2046382304 @default.
- W1966682037 cites W2054498103 @default.
- W1966682037 cites W2055588490 @default.
- W1966682037 cites W2060123522 @default.
- W1966682037 cites W2066119162 @default.
- W1966682037 cites W2069875612 @default.
- W1966682037 cites W2072380594 @default.
- W1966682037 cites W2074584594 @default.
- W1966682037 cites W2077703166 @default.
- W1966682037 cites W2084607024 @default.
- W1966682037 cites W2087221993 @default.
- W1966682037 cites W2090402875 @default.
- W1966682037 cites W2090928782 @default.
- W1966682037 cites W2094242997 @default.
- W1966682037 cites W2094835614 @default.
- W1966682037 cites W2096222626 @default.
- W1966682037 cites W2102887192 @default.
- W1966682037 cites W2105572099 @default.
- W1966682037 cites W2108235071 @default.
- W1966682037 cites W2109817285 @default.
- W1966682037 cites W2110795584 @default.
- W1966682037 cites W2111714805 @default.
- W1966682037 cites W2112807945 @default.
- W1966682037 cites W2114727688 @default.
- W1966682037 cites W2115978863 @default.
- W1966682037 cites W2116069273 @default.
- W1966682037 cites W2116934558 @default.
- W1966682037 cites W2124489451 @default.
- W1966682037 cites W2127451431 @default.
- W1966682037 cites W2127830613 @default.
- W1966682037 cites W2127891491 @default.
- W1966682037 cites W2130988210 @default.
- W1966682037 cites W2131882149 @default.
- W1966682037 cites W2133221875 @default.
- W1966682037 cites W2135147875 @default.
- W1966682037 cites W2138393270 @default.
- W1966682037 cites W2142535641 @default.
- W1966682037 cites W2145611701 @default.
- W1966682037 cites W2148200419 @default.
- W1966682037 cites W2148306131 @default.
- W1966682037 cites W2149749636 @default.
- W1966682037 cites W2150407723 @default.
- W1966682037 cites W2153104224 @default.
- W1966682037 cites W2159746652 @default.
- W1966682037 cites W2159999972 @default.